Meet our 2023 students

Name

Bradley Diggines

Project Title

A microfluidic toolkit for drug delivery particle discovery

Co-sponsored by the Institute of Chemical Biology EPSRC Centre for Doctoral Training and AstraZeneca

What were you doing before enrolling in the ICB CDT Programme?

I completed a MEng in Materials Science and Engineering during which I worked on a wide range of projects encompassing shape-morphing polymers, liquid crystals, plastic recycling machinery and DNA assemblies.

Why did you choose to apply for your particular project?

My project particularly appeals since it looks to apply many facets of engineering and science to tackle important challenges in drug delivery. I’m keen to use a wide range of tools, from lab chemistry and microfluidics to automation design, electronics and machine learning. I am also excited to work alongside collaborators at AstraZeneca to ensure that my work is directly linked to key requirements in the development of more effective drug delivery.

What are you looking forward to the most within the CDT programme?

I’m looking forward to taking advantage of the REACT and BOOST programmes to expand my awareness of entrepreneurship and industry in parallel to my research!

Please tell us a fun fact about yourself!

I once got paid to let Scream 6 be filmed in my apartment

Name

Nicole Fitikides

Project title

A new platform to understand and control protein liquid-liquid phase separation

What were you doing before your PhD?

I completed my undergraduate studies in Chemistry for Drug Discovery at the University of Bath and then went on to do a Master of Research at Imperial. My postgraduate project focused on developing cobalt complexes to inhibit the aggregation of the amyloid-β protein, a process directly linked to Alzheimer’s disease. I then worked as a research assistant for 6 months in the Vilar group at Imperial, on an environmental chemistry project involving the synthesis and large-scale production of a material for the removal of phosphate from water.

Why did you choose to apply for your particular project?

I have been very passionate about working in the field of neurodegenerative diseases for quite some time. My project involves the development of a new imaging tool for understanding and controlling liquid-liquid phase separation of proteins, with a focus on α-synuclein, a protein linked to Parkinson’s disease. What drew me to this project is its multidisciplinary character, as it involves research at the crossroads of synthetic and physical chemistry, cell culturing and protein expression, and microscopy. This project provides the opportunity to work on a new emerging topic and to contribute towards improving our understanding of Parkinson’s disease pathology. 

What are you looking forward to the most within the CDT programme?

Being in the CDT programme feels like belonging in a small, multicultural, and diverse community of young scientists. I am really looking forward to all activities, events, and courses the CDT organizes, bringing all students together to discuss science, learn from one another, and last but not least, have fun.

Please tell us a fun fact about yourself!

I love to make tiny origami paper boats that float in the water!

Name

Bronwyn Griffiths

Project Title

Development of optical probes based on encoded aptamers for RNA visualization in live cells

What were you doing before enrolling in the ICB CDT Programme?

Before joining the ICB CDT I was completing my MChem in Chemistry with Medicinal Chemistry at the University of St Andrews. During my final year I undertook a project where I was developing NIR emitting boron difluoride curcuminoid complexes within the Zysman-Colman group.

Why did you choose to apply for your particular project?

I studied a bit of chemical biology during my undergrad and loved it. I have experience with photophysics and synthesis from my MChem project, and so being able to apply that to a more biology-based project really interested me. The multidisciplinary aspects of my project appealed to me as it’ll allow me to learn loads during my time in the CDT. I was also really excited about the potential applications of this research and the opportunity to collaborate with such amazing people at Imperial College.

What are you looking forward to the most within the CDT programme?

Along with the research and learning so many new skills, I’m really looking forward to the science and communication course we get to do with the BBC.

Please tell us a fun fact about yourself!

I play both the violin and the harp – I played in the National Youth Orchestra of Scotland!

Name

Harry Lowe

Project Title

Dynamic Protein Biosynthesis via an Integrated Cell-on-a-Chip Platform Device

What were you doing before enrolling in the ICB CDT Programme?

Before my PhD, I undertook my MChem in Chemistry with Biological and Medicinal Chemistry at the University of York, completing my Masters project at the Laboratory for Drug Discovery in Neurodegeneration, sponsored by Harvard Medical School.

Why did you choose to apply for your particular project?

Throughout my undergraduate degree the biological aspects were always the most exciting. When deciding to pursue a PhD, I knew I wanted to move away from organic synthesis and delve into chemical biology. I applied for this project as it was a TEDtalk on cell-on-a-chip technology that led me to pursuing chemistry initially, and the idea of working on a blue-sky project with the potential to transform approaches to protein synthesis is very exciting.

What are you looking forward to the most within the CDT programme?

The EVOLVE programme offered by the CDT is particularly interesting, as well as the Science and Communication course with the BBC. The importance of these in developing both my ability to communicate my research to others and get hands-on experience in a field such as science policy are super exciting

Please tell us a fun fact about yourself!

I played Hamlet in my final year of A-Levels!

Name

Luke Parry

Project Title

Developing novel label-free technologies for studying drug molecules and their ability to induce protein complex formation in cells

Co-sponsored by the Institute of Chemical Biology EPSRC Centre for Doctoral Training and AstraZeneca

What were you doing before enrolling in the ICB CDT Programme?

I completed my undergraduate integrated master’s in Natural Sciences at Cambridge in 2022, and after a short break worked as a chemist in a research laboratory at CLS in Sandwich, before starting my 1+3 MRes/PhD at Imperial in October.

Why did you choose to apply for your particular project?

A few reasons, really. I wanted to do something relating drug research, I was looking for opportunities to do something practically useful with my as-yet purely theoretical knowledge, and I believe that big advancements increasingly occur at the interfaces between disciplines, making a multidisciplinary approach a must. This project, and the ICB CDT in general, ticked all the boxes, so it was a no-brainer for me.

What are you looking forward to the most within the CDT programme?

The variety! The programme puts on a range of additional courses, workshops and opportunities alongside my research, to help develop my skills not just as a researcher but as an effective scientist as a whole.

Please tell us a fun fact about yourself!

I have played at Twickenham stadium! This was as part of the Cambridge squad that played Oxford in the Varsity Match 2022. Don’t ask me about the result though…

Name

Fawaz Raja 

Project Title

Visualising the effects of pollution nanoparticles on respiratory epithelial cells at the air-liquid interface

Co-sponsored by the Institute of Chemical Biology EPSRC Centre for Doctoral Training and The NIHR Imperial Biomedical Research Centre (BRC) 

What were you doing before enrolling in the ICB CDT Programme?

Before joining the ICB CDT Programme, I graduated from Imperial with a BSc in Chemistry and spent a year working in the pharmaceutical industry at an early-stage drug development company in Manchester. Following that, I returned to Imperial to pursue an MRes in Chemical Biology with Bio-Entrepreneurship, where my research focused on the topographical characterisation of alpha-synuclein aggregates, contributing to a deeper understanding of protein misfolding in neurodegenerative diseases and reinforcing my decision to pursue a PhD.

Why did you choose to apply for your particular project?

Moving from the countryside to London made me acutely aware of the impact of urban pollution on our health. This experience sparked my interest in understanding how pollutants affect the body over time. My passion for cell culture, microscopy, and environmental health made this project a perfect fit, as it allows me to explore these interests while contributing to research that addresses a growing public health concern.

What are you looking forward to the most within the CDT programme?

Having already experienced the CDT as an MRes student, I’ve come to appreciate the wealth of opportunities it offers, both academically and socially. I’m particularly excited about the outreach and science communication programme at the BBC, as it will provide invaluable skills that I can use throughout my career. I look forward to honing my ability to communicate complex scientific ideas to diverse audiences and making a lasting impact through public engagement.

Please tell us a fun fact about yourself!

I’m a trained bartender. 

Name

Michelle Wong Chap Lan

Project Title

Developing new technologies to monitor translocation of chemicals in plant leaf 

This project is co-sponsored by the Institute of Chemical Biology, Imperial College London, and BASF SE

What were you doing before enrolling in the ICB CDT Programme?

Before my PhD, I did my MSci in Chemistry at Imperial, where I completed my final year project in the Membrane Biophysics group researching the effect of high pressure on membrane proton permeability.

Why did you choose to apply for your particular project?

I chose to apply for my project as my previous work studying proton permeability sparked my interest in investigating viscosity and permeability in more complex systems. This particular project fit well with this interest I developed, and I saw that the result of this project had great potential to have real-world impact, which was important to me.

What are you looking forward to the most within the CDT programme?

I look forward to developing skills outside of the lab, such as science communication and policy-making, all of which will be extremely helpful to me in any career I decide to pursue after my PhD.

Please tell us a fun fact about yourself!

I learnt all the dance routines in Barbie and the 12 Dancing Princesses off by heart at the age of 8!

Name

Kevin Yeung (he/him/his)

Project Title

Systematic discovery of functional allostery for next generation chemical modulators

What were you doing before enrolling in the ICB CDT Programme?

Before joining the CDT, I completed my bachelor’s degree at Princeton University in Chemical Engineering.

Why did you choose to apply for your particular project?

Having studied the design of de novo proteins during my undergraduate degree, I wanted to apply my knowledge of proteins to research and better understand the functionality of those in humans. Not only did this project aim to characterize allostery at a proteome-wide level — which could revolutionize drug discovery — but it also promised interdisciplinary collaboration. It would bring together computationalists, molecular biologists, and chemists, not unlike what many companies in the industry are doing nowadays with the recognition of the role that artificial intelligence would play in scientific research. You don’t often see that expected of a PhD student, and I was ready to take on the challenge.

What are you looking forward to the most within the CDT programme?

Of course, I hope that this degree will teach me scientific independence and allow me to develop a unique research direction I can take with me after my time here. Along the way, I particularly look forward to the scientific communication series to continue improving my writing skills and just learning from professors, lecturers, and other students!

Please tell us a fun fact about yourself!

I can consistently type over 100 wpm thanks to the SpongeBob SquarePants Typing Game. 

Name

Daisy Williams

Project Title

Chemical proteomic discovery of covalent ligands for novel drug targets in Myc-deregulated cancers

Co-sponsored by the Institute of Chemical Biology EPSRC Centre for Doctoral Training and Merck KGaA

What were you doing before enrolling in the ICB CDT Programme?

I completed my undergraduate degree in the U.S. where I double majored in Chemistry and Neuroscience. I then joined the ICB as an MRes student where I worked on the directed evolution of the Sortase A enzyme for the development of a ubiquitin profiling platform.

Why did you choose to apply for your particular project?

During my undergraduate degree I discovered a profound appreciation for the intersection of chemical principles and complex biological systems which ultimately led to my passion for chemical biology. This project represents the culmination of my interests in organic synthesis, chemical proteomics and machine learning. I am eager to apply my knowledge of molecular biology methods to investigate cysteine reactivity and covalent ligandability using chemical probes and high-throughput proteomics techniques. This work would afford me the opportunity to participate in identifying potential targets for Myc-deregulated cancers and, in consequence, play a role in expanding the drug space.

What are you looking forward to the most within the CDT programme?

The CDT offers interdisciplinary and collaborative opportunities that I have already been able to appreciate through my experience as an MRes student in the programme. The CDT’s strong emphasis on outreach and social engagement aligns with my own priorities and I am particularly eager to become involved in these opportunities. Additionally, I look forward to refining my science communication skills through the extensive range of courses and programs offered by the CDT.

Please tell us a fun fact about yourself!

I have lived in three countries so far in my life!

Name

Jiaying Zhuang

Project Title

Unlocking deubiquitinase (DUB) probe discovery by high-throughput chemical proteomics

This project is co-sponsored by the Institute of Chemical Biology, Imperial College London, and Ubiquigent

What were you doing before enrolling in the ICB CDT Programme?

I completed my MSci Chemistry with Medicinal Chemistry and a Year in Industry degree at Imperial College London.

Why did you choose to apply for your particular project?

As a medicinal chemistry student, I have always wanted to apply chemistry knowledge to a biological context and help contribute to drug discovery and development. This PhD project enables me to utilise my chemistry skills and employ methods of molecular biology to develop a new high-throughput chemical proteomic technology platform which will bridge the current gap in tools to investigate DUB activity across intact cell lines. Industrial collaboration with Ubiquigent will link me to more state-of-the-art discovery and screening platforms and another group of talented scientists, which I believe is more than beneficial for my project.

What are you looking forward to the most within the CDT programme?

I am particularly interested in outreach and engagement that the CDT is dedicated to, since it is a perfect opportunity to share all the exciting cutting-edge research with the public and raise scientific awareness!

Please tell us a fun fact about yourself!

I am quadrilingual - English, Mandarin, Japanese, and Shanghainese (if that counts? :D).

Name

Rohan Sekhri

Project Title

3D printed synthetic tissues for patterned interactions with cellular populations

Co-sponsored by the Institute of Chemical Biology EPSRC Centre for Doctoral Training and The NIHR Imperial Biomedical Research Centre (BRC) 

What were you doing before enrolling in the ICB CDT Programme?

Before my PhD, I completed a BSc in Chemistry at Durham University followed by a 1-year MRes at Imperial in Biological and Physical Chemistry. My research focussed on understanding protein aggregation in Parkinson’s disease using both computational and experimental techniques.

Why did you choose to apply for your particular project?

I am very interested in synthetic biology and its practical application in the development of artificial cells and tissues so this project seemed like an obvious choice. Additionally, the interdisciplinary nature of the project appealed to me, the chance to combine aspects of engineering, chemistry and biology excites me. 

What are you looking forward to the most within the CDT programme?

I’m looking forward to making the most of the ICBs wide range of opportunities outside of just research, especially science communication with the BBC!

Please tell us a fun fact about yourself!

Having spent three years at an international school in New Delhi as a child, I can play rock paper scissors in Korean!

Name

Lucy Dan

Project title

Developing novel p21-disrupting peptides to prevent quiescence and resistance to chemotherapy

This project is funded by the CRUK Convergence Science Centre

What were you doing before enrolling in the ICB CDT Programme?

I earned my Master’s degree in biological sciences from Durham University. My research project focused on the role of pro-survival autophagy in oesophageal adenocarcinoma.

Why did you choose to apply for your particular project?

As a Convergence Science PhD student, my project is hosted jointly across three different laboratories within Imperial and the Institute of Cancer Research. I am looking forward to using multidisciplinary approaches to investigate novel ways to target the activities of cyclin-dependent kinases for cancer therapy.  

What are you looking forward to the most within the CDT programme?

I am looking forward to the sharing of ideas between scientists from different fields. I am also excited about the opportunity to improve my scientific communication skills.

Please tell us a fun fact about yourself!

When not in the lab, you can normally find me on the hockey pitch.

Name

Naura Fakhira Antariksa

Project Title

Mapping long-range G-G base pairing interaction within the human genome

Naura is sponsored by Imperial College's President's PhD Scholarship Programme

What were you doing before enrolling in the ICB CDT Programme?

I completed my undergraduate in Applied Chemistry at Kyushu University, Japan and continued my Master’s education at EPFL, Switzerland. In Switzerland I trained under Prof. Yimon Aye, with a project focused on investigating the interaction between protein and a drug-like molecule. I then did a 6-month internship at Prof. Julius Fredens’ group at the National University of Singapore, focusing on protein delivery and biosensor development.

Why did you choose to apply for your particular project?

I am interested in this project as it expands the work on investigating the biological importance of a non-canonical DNA structure called G-quadruplexes (G4s), which have been linked to cancer and other diseases. This project would allow me to broaden my chemical biology skillset, particularly in genomics and bioinformatics. Importantly, the project could inform on the “druggability” of nucleic acids, which is something I am excited to explore in my future career.

What are you looking forward to the most within the CDT programme?

I am enthusiastic about joining the various doctoral courses for professional development, as they would help me develop the“soft-skills” that are often overlooked in academia.

Please tell us a fun fact about yourself!

I have 9 cats back home in Indonesia! They were all rescued as kittens from the streets.

Name

Li Lei

Project Title

Using Computational Chemistry Methods (Molecular Dynamics) to Simulate Protein Interaction

What were you doing before your PhD?

I complete my chemistry MSci degree at Imperial College London.

Why did you choose to apply for your particular project?

My project is centred on exploring a diverse array of computational methodologies to conduct thorough studies in both chemical and biological domains. I derive immense satisfaction not only from understanding new research about proteins but also from actively innovating and creating novel workflow as I progress in my research.

What are you looking forward to the most within the CDT programme?

Engaging in training programs and enrolling in courses facilitated by ICB and CDT will significantly enhance my researching skills and skills outside lab. This endeavour also represents a compelling opportunity to forge meaningful connections with like-minded professionals within the department.

Please tell us a fun fact about yourself!

A 10/10 trip planner

Name

Long-Hung Pham

Project Title

Allosteric targeting of the proteome

This project is sponsored by the Vingroup Scholarship Program for Vietnamese students and the Department of Chemistry.

What were you doing before enrolling in the ICB CDT Programme?

Before joining the CDT, I completed a Bachelor of Pharmacy degree at the University of Medicine and Pharmacy at Ho Chi Minh City, Vietnam. My focus was chemical informatics applied to medicinal chemistry.

Why did you choose to apply for your particular project?

I consider myself very lucky to participate in this highly collaborative project between computational and experimental researchers. My area is primarily chemical informatics, and now I have a chance to learn more about mathematics, network science, together with receiving invaluable practical advice from chemical biologists. I hope my research can one day play a small part to help accelerate covalent drug discovery efforts using computer prediction.

What are you looking forward to the most within the CDT programme?

I look forward to learning and working with the prominent professors and interdisciplinary research of the CDT. I also hope to have a chance to learn from fellow graduate students who I think are all very talented.

Please tell us a fun fact about yourself!

I’m a fan of old Nintendo and 32-bit Capcom games.

Name

Maria Portela (she/her)

Project Title

Spores-on-a-chip - investigating the responsiveness of environmental soil spore communities at the single-cell level

Maria is sponsored by Imperial College's President's PhD Scholarship Programme

What were you doing before enrolling in the ICB CDT Programme?

Before my PhD I completed an MEng in Molecular Bioengineering at Imperial. My Masters research was on building and characterising ATP biosensors for the study of metabolic heterogeneity in yeast. I also did a year placement at GSK, working on single-cell CRISPR screens in primary immune cells for drug target identification.

Why did you choose to apply for your particular project?

Spores are specialised microbial cells with high resistance properties that play key roles in microbiome diversity and survival. Understanding their function and interactions, particularly within the soil microbiome, has the potential to improve sustainable agricultural, bioremediation and biocontrol strategies, and even benefit human health through new drugs and safer foods. However, and despite their importance, much is still unknown about the single-cell dynamics of spore formation and revival. 

My interest in this research comes primarily from its potential to have a positive impact on building a green economy and a more sustainable future. I also wanted to learn new skills and work across disciplines: and this project will allow me to do research at the interface between microbiology and engineering!

The project is hosted by the Microbiome-Microfluidics and Microscopy lab at the Department of Bioengineering, led by Dr Claire Stanley, and funded by the Imperial College President’s PhD Scholarship. I am an incorporated member of the CDT.

What are you looking forward to the most within the CDT programme?

I am looking forward to the training opportunities, particularly when it comes to science communication and policy making.

Please tell us a fun fact about yourself!

I am also a choral singer and composer!

Name

Sandhya Sridhar

Project Title

Chemical precision tools to probe O-linked protein glycosylation in metastatic breast cancer.

This project is funded by CRUK

What were you doing before your PhD?

I completed my BSc in Biomedical Sciences from Queen Mary University (London) and MPhil (MRC Cancer Unit) from the University of Cambridge.
Following graduation, I worked for several years as a Scientific Officer in the Gene Function team at the ICR in London. I was fortunate to be part of a great clinical research team that used high throughput drug/CRIPSR screening methods to identify therapeutic targets in breast cancer.

Why did you choose to apply for your particular project?

Coming from an oncology research background, I have always been interested in understanding the molecular mechanisms of disease and how we can use this knowledge to inform diagnoses and therapy. I was really excited by the interdisciplinary nature of this project, and the opportunity to use novel chemical biology tools and techniques to understand the role of the glycoproteome in cancer, something that is relevant but relatively understudied. 

What are you looking forward to the most within the CDT programme?

I am looking forward to engaging and collaborating with scientists of different backgrounds to share knowledge and learn more. I’m also excited about the varied and interesting training programs offered by the programme, such as the EVOLVE and SciComm series.  

Please tell us a fun fact about yourself!

I’m a trained Indian classical/Bollywood dancer and love to perform and host workshops

Name

He Wang

Project Title

Sustainable Palladium Catalysis

This studentship is sponsored by the Chinese Scholarship Council and the Department of Chemistry 

What were you doing before enrolling in the ICB CDT Programme?

Before I started my PhD, I majored in applied chemistry in China as an undergraduate. In 2022-2023, I studied in Imperial College as master student (MRes Catalysis: Chemistry and Engineering).

Why did you choose to apply for your particular project?

I have been involved in research projects related to catalysing organic reactions with precious metal catalysts since my undergraduate degree, and I am interested and confident in completing my PhD in this direction. Also, I believe this project is promising for providing greener and more sustainable catalytic pathways.

What are you looking forward to the most within the CDT programme?

I hope to learn more about combining theoretical knowledge of chemistry with industrial practice in the CDT programme. Apart from that, I would like to learn about entrepreneurship.

Please tell us a fun fact about yourself!

I am an enthusiastic and responsible person. I would love to help others when they are in need. In my daily life, I enjoy sports (badminton, table tennis, swimming...), approaching nature (travelling, hiking).

Name

Yujia Zhang

Project Title

Enabling Targeted Protein Degradation in Bacteria for Degrader Antibiotics

This studentship is sponsored by the Francis Crick Institute and the Department of Chemistry 

What were you doing before enrolling in the ICB CDT Programme?

I studied Molecular Cellular Biology at the University of Glasgow, and took on an industrial placement at Sygnature Discovery, a drug discovery CRO in Nottingham for a year, where I developed high-throughput screening assays to find early drug candidates.

Why did you choose to apply for your particular project?

I am fascinated by the mechanism of degrader modalities, and the intricacies and challenges of protein-protein interface and induced proximity. To date TPD application has only been explored in eukaryotic cells, so the idea of translating this paradigm into bacteria leveraging the prokaryotic proteases was very interesting to me. I am also excited by the prospect that it may help us find next-generation antibiotics that overcome antimicrobial resistance.

What are you looking forward to the most within the CDT programme?

The opportunity to network with other like-minded PhD students, find common grounds and experience the academic trainings to become better scientists.

Please tell us a fun fact about yourself!

I got quite into crafting scale models recently.

Name

Baiqiu Tang

Project Title

Enhancing Photosynthesis in Clamydomonas reinhardtii using carbonic anhydrase mimetic

What were you doing before enrolling in the ICB CDT Programme?

I completed my MSci Chemistry degree at Imperial College London.

Why did you choose to apply for your particular project?

As a chemistry student, I am committed to applying my knowledge beyond the traditional boundaries of the discipline. From an early age, I have had a strong interest in plants, which has since developed into a deep passion for plant-related research. My current project embodies a meaningful integration of my academic background and personal interests. Specifically, I am developing a high-throughput screening platform to identify chemicals with the potential to accelerate or enhance plant growth, thereby increasing crop yields and overall food production. Through this work, we aim to contribute to efforts to alleviate — and ultimately eliminate — the hunger affecting millions of people worldwide. The CDT programme offers interdisciplinary training that will provide me with a broader set of skills, enabling both my development as a researcher and the advancement of my project.

What are you looking forward to the most within the CDT programme?

Having been part of the CDT, I deeply value its interdisciplinary environment and strong sense of community. The programme’s focus on science communication and public engagement aligns with my values, and I am particularly excited about outreach opportunities such as the BBC initiative. Beyond lab-based research, I appreciate the variety of activities offered, including conferences and symposia that expand my perspective across disciplines, as well as external training opportunities that enhance my development as a well-rounded researcher. 

Please tell us a fun fact about yourself!

I am a fan of road cycling and running. I have cycled London-Brighton-London within 8 hours.