Publications
Notable Recent Publications
These are some recent publications which give a flavour of the research from the Barclay lab. For a complete list of publications, please see below.
Species difference in ANP32A underlies influenza A virus polymerase host restriction. Nature (2016).
Jason S. Long, Efstathios S. Giotis, Olivier Moncorgé, Rebecca Frise, Bhakti Mistry, Joe James, Mireille Morisson, Munir Iqbal, Alain Vignal, Michael A. Skinner & Wendy S. Barclay
This paper identified a key factor that explained why the polymerases from avian influenza viruses are restricted in humans. For more, please see the associated New and Views.
See our latest ANP32 papers here: eLIFE, Journal of Virology, Journal of Virology.
The mechanism of resistance to favipiravir in influenza. PNAS (2018).
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Internal genes of a highly pathogenic H5N1 influenza virus determine high viral replication in myeloid cells and severe outcome of infection in mice. Plos Path. (2018).
Hui Li*, Konrad C. Bradley*, Jason S. Long, Rebecca Frise, Jonathan W. Ashcroft, Lorian C. Hartgroves, Holly Shelton, Spyridon Makris, Cecilia Johansson, Bin Cao & Wendy S. Barclay
Why do avian influenza viruses like H5N1 cause such severe disease in humans? This paper demonstrated that H5N1 viruses replicate better than human viruses in myeloid cells from mice leading to a cytokine storm and more severe disease.
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Journal articleLong JS, Howard WA, Nunez A, et al., 2013,
The Effect of the PB2 Mutation 627K on Highly Pathogenic H5N1 Avian Influenza Virus Is Dependent on the Virus Lineage
, JOURNAL OF VIROLOGY, Vol: 87, Pages: 9983-9996, ISSN: 0022-538X- Author Web Link
- Cite
- Citations: 39
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Journal articleAlmond MH, Edwards MR, Barclay WS, et al., 2013,
Obesity and susceptibility to severe outcomes following respiratory viral infection
, THORAX, Vol: 68, Pages: 684-686, ISSN: 0040-6376- Author Web Link
- Cite
- Citations: 51
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Journal articleShelton H, Roberts KL, Molesti E, et al., 2013,
Mutations in haemagglutinin that affect receptor binding and pH stability increase replication of a PR8 influenza virus with H5 HA in the upper respiratory tract of ferrets and may contribute to transmissibility
, JOURNAL OF GENERAL VIROLOGY, Vol: 94, Pages: 1220-1229, ISSN: 0022-1317- Author Web Link
- Cite
- Citations: 49
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Journal articleFouchier RAM, Garcia-Sastre A, Kawaoka Y, et al., 2013,
Transmission Studies Resume For Avian Flu
, SCIENCE, Vol: 339, Pages: 520-521, ISSN: 0036-8075- Author Web Link
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- Citations: 23
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Journal articleCauldwell AV, Moncorge O, Barclay WS, 2013,
Unstable Polymerase-Nucleoprotein Interaction Is Not Responsible for Avian Influenza Virus Polymerase Restriction in Human Cells
, JOURNAL OF VIROLOGY, Vol: 87, Pages: 1278-1284, ISSN: 0022-538X- Author Web Link
- Cite
- Citations: 32
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Journal articleMoncorge O, Long JS, Cauldwell AV, et al., 2013,
Investigation of Influenza Virus Polymerase Activity in Pig Cells
, JOURNAL OF VIROLOGY, Vol: 87, Pages: 384-394, ISSN: 0022-538X- Author Web Link
- Cite
- Citations: 30
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Journal articleIto K, Ashcroft J, Brookes D, et al., 2013,
Inhibitory Effects Of Rv1088, A Narrow Spectrum Kinase Inhibitor, On Cytokine Production In Response To Pandemic Flu Infections Of Primary Respiratory Cell Cultures
, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 187, ISSN: 1073-449X -
Journal articleSridhar S, Begom S, Bermingham A, et al., 2012,
Predominance of heterosubtypic IFN-?-only-secreting effector memory T cells in pandemic H1N1 naive adults
, EUROPEAN JOURNAL OF IMMUNOLOGY, Vol: 42, Pages: 2913-2924, ISSN: 0014-2980- Author Web Link
- Cite
- Citations: 27
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Journal articleRoberts KL, Shelton H, Stilwell P, et al., 2012,
Transmission of a 2009 H1N1 Pandemic Influenza Virus Occurs before Fever Is Detected, in the Ferret Model
, PLOS ONE, Vol: 7, ISSN: 1932-6203- Author Web Link
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- Citations: 27
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Journal articleShelton H, Smith M, Hartgroves L, et al., 2012,
An influenza reassortant with polymerase of pH1N1 and NS gene of H3N2 influenza A virus is attenuated in vivo
, JOURNAL OF GENERAL VIROLOGY, Vol: 93, Pages: 998-1006, ISSN: 0022-1317- Author Web Link
- Cite
- Citations: 15
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