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• Journal article
  Almond MH, Edwards MR, Barclay WS, Johnston SLet al., 2013,

  Obesity and susceptibility to severe outcomes following respiratory viral infection

  , THORAX, Vol: 68, Pages: 684-686, ISSN: 0040-6376
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  • Citations: 57
• Journal article
  Shelton H, Roberts KL, Molesti E, Temperton N, Barclay WSet al., 2013,

  Mutations in haemagglutinin that affect receptor binding and pH stability increase replication of a PR8 influenza virus with H5 HA in the upper respiratory tract of ferrets and may contribute to transmissibility

  , JOURNAL OF GENERAL VIROLOGY, Vol: 94, Pages: 1220-1229, ISSN: 0022-1317
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  • Citations: 51
• Journal article
  Fouchier RAM, Garcia-Sastre A, Kawaoka Y, Barclay WS, Bouvier NM, Brown IH, Capua I, Chen H, Compans RW, Couch RB, Cox NJ, Doherty PC, Donis RO, Feldmann H, Guan Y, Katz JM, Kiselev OI, Klenk HD, Kobinger G, Liu J, Liu X, Lowen A, Mettenleiter TC, Osterhaus ADME, Palese P, Peiris JSM, Perez DR, Richt JA, Schultz-Cherry S, Steel J, Subbarao K, Swayne DE, Takimoto T, Tashiro M, Taubenberger JK, Thomas PG, Tripp RA, Tumpey TM, Webby RJ, Webster RGet al., 2013,

  Transmission Studies Resume For Avian Flu

  , SCIENCE, Vol: 339, Pages: 520-521, ISSN: 0036-8075
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  • Citations: 26
• Journal article
  Cauldwell AV, Moncorge O, Barclay WS, 2013,

  Unstable Polymerase-Nucleoprotein Interaction Is Not Responsible for Avian Influenza Virus Polymerase Restriction in Human Cells

  , JOURNAL OF VIROLOGY, Vol: 87, Pages: 1278-1284, ISSN: 0022-538X
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  • Citations: 35
• Journal article
  Moncorge O, Long JS, Cauldwell AV, Zhou H, Lycett SJ, Barclay WSet al., 2013,

  Investigation of Influenza Virus Polymerase Activity in Pig Cells

  , JOURNAL OF VIROLOGY, Vol: 87, Pages: 384-394, ISSN: 0022-538X
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  • Citations: 38
• Journal article
  Ito K, Ashcroft J, Brookes D, Cocking R, Barclay WSet al., 2013,

  Inhibitory Effects Of Rv1088, A Narrow Spectrum Kinase Inhibitor, On Cytokine Production In Response To Pandemic Flu Infections Of Primary Respiratory Cell Cultures

  , AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 187, ISSN: 1073-449X
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• Journal article
  Sridhar S, Begom S, Bermingham A, Ziegler T, Roberts KL, Barclay WS, Openshaw P, Lalvani Aet al., 2012,

  Predominance of heterosubtypic IFN-?-only-secreting effector memory T cells in pandemic H1N1 naive adults

  , EUROPEAN JOURNAL OF IMMUNOLOGY, Vol: 42, Pages: 2913-2924, ISSN: 0014-2980
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  • Citations: 28
• Journal article
  Roberts KL, Shelton H, Stilwell P, Barclay WSet al., 2012,

  Transmission of a 2009 H1N1 Pandemic Influenza Virus Occurs before Fever Is Detected, in the Ferret Model

  , PLOS ONE, Vol: 7, ISSN: 1932-6203
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  • Citations: 32
• Journal article
  Shelton H, Smith M, Hartgroves L, Stilwell P, Roberts K, Johnson B, Barclay Wet al., 2012,

  An influenza reassortant with polymerase of pH1N1 and NS gene of H3N2 influenza A virus is attenuated <i>in vivo</i>

  , JOURNAL OF GENERAL VIROLOGY, Vol: 93, Pages: 998-1006, ISSN: 0022-1317
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  • Citations: 16
• Journal article
  Everitt AR, Clare S, Pertel T, John SP, Wash RS, Smith SE, Chin CR, Feeley EM, Sims JS, Adams DJ, Wise HM, Kane L, Goulding D, Digard P, Anttila V, Baillie JK, Walsh TS, Hume DA, Palotie A, Xue Y, Colonna V, Tyler-Smith C, Dunning J, Gordon SB, GenISIS Investigators, MOSAIC Investigators, Smyth RL, Openshaw PJ, Dougan G, Brass AL, Kellam Pet al., 2012,

  IFITM3 restricts the morbidity and mortality associated with influenza.

  , Nature, Vol: 484, Pages: 519-523

  The 2009 H1N1 influenza pandemic showed the speed with which a novel respiratory virus can spread and the ability of a generally mild infection to induce severe morbidity and mortality in a subset of the population. Recent in vitro studies show that the interferon-inducible transmembrane (IFITM) protein family members potently restrict the replication of multiple pathogenic viruses1, 2, 3, 4, 5, 6, 7. Both the magnitude and breadth of the IFITM proteins’ in vitro effects suggest that they are critical for intrinsic resistance to such viruses, including influenza viruses. Using a knockout mouse model8, we now test this hypothesis directly and find that IFITM3 is essential for defending the host against influenza A virus in vivo. Mice lacking Ifitm3 display fulminant viral pneumonia when challenged with a normally low-pathogenicity influenza virus, mirroring the destruction inflicted by the highly pathogenic 1918 ‘Spanish’ influenza9, 10. Similar increased viral replication is seen in vitro, with protection rescued by the re-introduction of Ifitm3. To test the role of IFITM3 in human influenza virus infection, we assessed the IFITM3 alleles of individuals hospitalized with seasonal or pandemic influenza H1N1/09 viruses. We find that a statistically significant number of hospitalized subjects show enrichment for a minor IFITM3 allele (SNP rs12252-C) that alters a splice acceptor site, and functional assays show the minor CC genotype IFITM3 has reduced influenza virus restriction in vitro. Together these data reveal that the action of a single intrinsic immune effector, IFITM3, profoundly alters the course of influenza virus infection in mouse and humans.

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