Notable Recent Publications
These are some recent publications which give a flavour of the research from the Barclay lab. For a complete list of publications, please see below.
Species difference in ANP32A underlies influenza A virus polymerase host restriction. Nature (2016).
Jason S. Long, Efstathios S. Giotis, Olivier Moncorgé, Rebecca Frise, Bhakti Mistry, Joe James, Mireille Morisson, Munir Iqbal, Alain Vignal, Michael A. Skinner & Wendy S. Barclay
This paper identified a key factor that explained why the polymerases from avian influenza viruses are restricted in humans. For more, please see the associated New and Views.
Internal genes of a highly pathogenic H5N1 influenza virus determine high viral replication in myeloid cells and severe outcome of infection in mice. Plos Path. (2018).
Hui Li*, Konrad C. Bradley*, Jason S. Long, Rebecca Frise, Jonathan W. Ashcroft, Lorian C. Hartgroves, Holly Shelton, Spyridon Makris, Cecilia Johansson, Bin Cao & Wendy S. Barclay
Why do avian influenza viruses like H5N1 cause such severe disease in humans? This paper demonstrated that H5N1 viruses replicate better than human viruses in myeloid cells from mice leading to a cytokine storm and more severe disease.
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Journal articleLong JS, Howard WA, Nunez A, et al., 2013,
Journal articleAlmond MH, Edwards MR, Barclay WS, et al., 2013,
Journal articleShelton H, Roberts KL, Molesti E, et al., 2013,
Journal articleFouchier RAM, Garcia-Sastre A, Kawaoka Y, et al., 2013,
Journal articleCauldwell AV, Moncorge O, Barclay WS, 2013,
Journal articleMoncorge O, Long JS, Cauldwell AV, et al., 2013,
Journal articleIto K, Ashcroft J, Brookes D, et al., 2013,
Inhibitory Effects Of Rv1088, A Narrow Spectrum Kinase Inhibitor, On Cytokine Production In Response To Pandemic Flu Infections Of Primary Respiratory Cell Cultures, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 187, ISSN: 1073-449X
Journal articleSridhar S, Begom S, Bermingham A, et al., 2012,
Journal articleRoberts KL, Shelton H, Stilwell P, et al., 2012,
Journal articleShelton H, Smith M, Hartgroves L, et al., 2012,
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