BibTex format

author = {Moly, A and Luan, S and Mari, Z and Anderson, WS and Salimpour, Y and Constandinou, TG and Grand, L},
doi = {10.1109/BIOCAS.2018.8584699},
publisher = {IEEE},
title = {Embedded phase-amplitude coupling based closed-loop platform forParkinson’s Disease},
url = {},
year = {2018}

RIS format (EndNote, RefMan)

AB - Deep Brain Stimulation (DBS) is a widely used clinical therapeutic modality to treat Parkinsons disease refractory symptoms and complications of levodopa therapy. Currently available DBS systems use continuous, open-loop stimulation strategies. It might be redundant and we could extend the battery life otherwise. Recently, robust electrophysiological signatures of Parkinsons disease have been characterized in motor cortex of patients undergoing DBS surgery. Reductions in the beta-gamma Phase-Amplitude coupling (PAC) correlated with symptom improvement, and the therapeutic effects of DBS itself. We aim to develop a miniature, implantable andadaptive system, which only stimulates the neural target, when triggered by the output of the appropriate PAC algorithm. As a first step, in this paper we compare published PAC algorithms by using human data intra-operatively recorded from Parkinsonian patients. We then introduce IIR maskingfor later achieving fast and low-power FPGA implementation of PAC mapping for intra-operative studies. Our closed-loop application is expected to consume significantly less power than current DBS systems, therefore we can increase the battery life, without compromising clinical benefits.
AU - Moly,A
AU - Luan,S
AU - Mari,Z
AU - Anderson,WS
AU - Salimpour,Y
AU - Constandinou,TG
AU - Grand,L
DO - 10.1109/BIOCAS.2018.8584699
PY - 2018///
SN - 2163-4025
TI - Embedded phase-amplitude coupling based closed-loop platform forParkinson’s Disease
UR -
ER -