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Journal articleGorgy T, Paterson A, Vitharana K, et al., 2014,
MOLECULAR PHYSIOLOGY MONITORING OF OVARIAN CANCER EX VIVO, INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, Vol: 24, Pages: 402-402, ISSN: 1048-891X
Conference paperJeffcote T, Jewell S, Pahl C, et al., 2014,
INTRAPARENCHYMAL ELECTRODE RECORDINGS OF CORTICAL SPREADING DEPOLARISATION AND CONTINUOUS SEIZURE ACTIVITY - NEUROVASCULAR DISRUPTION AND SEIZURE OXYGEN THRESHOLDS, 11th Symposium of the International-Neurotrauma-Society, Publisher: MARY ANN LIEBERT, INC, Pages: A51-A51, ISSN: 0897-7151
Journal articleJeffcote T, Hinzman JM, Jewell SL, et al., 2014,
Detection of spreading depolarization with intraparenchymal electrodes in the injured human brain, Neurocritical Care, Vol: 20, Pages: 21-31, ISSN: 1541-6933
BackgroundSpreading depolarization events following ischemic and traumatic brain injury are associated with poor patient outcome. Currently, monitoring these events is limited to patients in whom subdural electrodes can be placed at open craniotomy. This study examined whether these events can be detected using intra-cortical electrodes, opening the way for electrode insertion via burr hole.MethodsAnimal work was carried out on adult Sprague–Dawley rats in a laboratory setting to investigate the feasibility of recording depolarization events. Subsequently, 8 human patients requiring craniotomy for traumatic brain injury or aneurysmal subarachnoid hemorrhage were monitored for depolarization events in an intensive care setting with concurrent strip (subdural) and depth (intra-parenchymal) electrode recordings.Results(1) Depolarization events can be reliably detected from intra-cortically placed electrodes. (2) A reproducible slow potential change (SPC) waveform morphology was identified from intra-cortical electrodes on the depth array. (3) The depression of cortical activity known to follow depolarization events was identified consistently from both intra-cortical and sub-cortical electrodes on the depth array.ConclusionsIntra-parenchymally sited electrodes can be used to consistently identify depolarization events in humans. This technique greatly extends the capability of monitoring for spreading depolarization events in injured patients, as electrodes can be sited without the need for craniotomy. The method provides a new investigative tool for the evaluation of the contribution of these events to secondary brain injury in human patients.
Journal articleKothur RR, Hall J, Patel BA, et al., 2014,
A low pH sensor from an esterified pillararene, CHEMICAL COMMUNICATIONS, Vol: 50, Pages: 852-854, ISSN: 1359-7345
Journal articleHamaoui K, Aftab A, Gowers S, et al., 2013,
A NOVEL ADENOSINE/LIDOCAINE PRESERVATION SOLUTION FOR RENAL MACHINE PERFUSION - A POTENTIAL ALTERNATIVE TO UNIVERSITY OF WISCONSIN SOLUTION?, TRANSPLANT INTERNATIONAL, Vol: 26, Pages: 336-336, ISSN: 0934-0874
Journal articleHamaoui K, Gowers S, Mastoridis S, et al., 2013,
NOVEL REAL-TIME MICRODIALYSIS MONITORING OF TISSUE VIABILITY - A PROMISING NEW TOOL IN MARGINAL KIDNEY TRANSPLANTATION?, TRANSPLANT INTERNATIONAL, Vol: 26, Pages: 336-336, ISSN: 0934-0874
Journal articleHamaoui K, Smith R, Gowers S, et al., 2013,
GRAFT PRECONDITIONING USING LOCALISING ANTICOAGULANT FUSION PROTEINS IN KIDNEY TRANSPLANTATION, TRANSPLANT INTERNATIONAL, Vol: 26, Pages: 67-67, ISSN: 0934-0874
Conference paperBoutelle MG, Rogers ML, Leong CL, et al., 2013,
The dynamics of glucose and lactate metabolism in the injured brain during spreading depolarisation, 24th Biennial Meeting of the International-Society-for-Neurochemistry and the American-Society-for-Neurochemistry, Publisher: WILEY-BLACKWELL, Pages: 48-48, ISSN: 0022-3042
Journal articleRogers ML, Feuerstein D, Leong CL, et al., 2013,
Continuous Online Microdialysis Using Microfluidic Sensors: Dynamic Neurometabolic Changes during Spreading Depolarization, ACS CHEMICAL NEUROSCIENCE, Vol: 4, Pages: 799-807, ISSN: 1948-7193
- Author Web Link
- Citations: 59
Journal articleRogers ML, Brennan PA, Leong CL, et al., 2013,
Online rapid sampling microdialysis (rsMD) using enzyme-based electroanalysis for dynamic detection of ischaemia during free flap reconstructive surgery, ANALYTICAL AND BIOANALYTICAL CHEMISTRY, Vol: 405, Pages: 3881-3888, ISSN: 1618-2642
- Author Web Link
- Citations: 25
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