@inbook{Campos-Pires:2023:10.1007/978-3-031-10355-1,
author = {Campos-Pires, R and Dickinson, R},
booktitle = {Blast Injury Science and Engineering: A Guide for Clinicians and Researchers},
doi = {10.1007/978-3-031-10355-1},
editor = {Bull and Clasper and Mahoney},
pages = {315--331},
publisher = {Springer Cham},
title = {Modelling Blast Brain Injury},
url = {http://dx.doi.org/10.1007/978-3-031-10355-1},
year = {2023}
}

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TY  - CHAP
AB  - The consequences of blast traumatic braininjury (blast-TBI) in humans are largely determinedby the characteristics of the traumainsult and, within certain limits, the individualresponses to the lesions inflicted (Maas et al.,Lancet Neurol. 2008;7:728–41). In blast-TBI,the mechanisms of brain vulnerability to thedetonation of an explosive device are not completelyunderstood. They most likely resultfrom a combination of the different physicalaspects of the blast phenomenon, specificallyextreme pressure oscillations (blast overpressurewave), projectile penetrating fragmentsand acceleration–deceleration forces, creatinga spectrum of brain injury that ranges frommild to severe blast-TBI(Hicks et al., JTrauma. 2010; 68:1257-63).The pathophysiologyof penetrating and inertially drivenblast-TBI has been extensively investigatedfor many years. However, the brain damagecaused by blast overpressure is much lessunderstood and is unique to this type of TBI(Chen et al., J Neurotrauma. 2009; 26:861–76). Indeed, there continues to be debate abouthow the pressure wave is transmitted andreflected through the brain and how it causescellular damage (Nakagawa et al., JNeurotrauma. 2011; 28:1101–19). No singlemodel can mimic the clinical and mechanicalcomplexity resulting from a real-lifeblast-TBI (Chen et al., J Neurotrauma. 2009;26:861–76). The different models, non-biological(in silico or surrogate physical) andbiological (ex vivo, in vitro or in vivo), tend tocomplement each other.
AU  - Campos-Pires,R
AU  - Dickinson,R
DO  - 10.1007/978-3-031-10355-1
EP  - 331
PB  - Springer Cham
PY  - 2023///
SN  - 978-3-031-10354-4
SP  - 315
TI  - Modelling Blast Brain Injury
T1  - Blast Injury Science and Engineering: A Guide for Clinicians and Researchers
UR  - http://dx.doi.org/10.1007/978-3-031-10355-1
UR  - https://doi.org/10.1007/978-3-031-10355-1_32
ER  - 

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