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  • Conference paper
    Nguyen TT, Davey T, Proud W, 2014,

    Percolation of Gas and Attenuation of Shock Waves through Granular Beds and Perforated Sheets

    , New Trends in Research of Energetic Materials
  • Conference paper
    Villette CC, Phillips ATM, 2014,

    Combined finite element and musculoskeletal predictive structural modelling of the femur: Potential mechanobiology applications

    , 11th World Congress on Computational Mechanics
  • Conference paper
    Villette CC, Phillips ATM, 2014,

    Combined predictive structural finite element and musculoskeletal modeling of bone structure for study of fracture under solid blast condition

    , IStructE Young Researchers' Conference
  • Conference paper
    Reichenbach T, 2014,

    Otoacoustic emission through waves on Reissner's membrane and bone deformation

    , ISSN: 2221-3767

    The inner ear acts not only as a detector of sound, but can produce sound itself. These otoacoustic emissions are generated by an active process in the inner ear. The active process leads to a nonlinearity that produces distortion that is emitted as sound from the ear. How such a distortion propagates from its generation site within the inner ear back to the middle ear remains, however, unclear. Here we describe two novel modes of wave propagation in the cochlea, namely a wave on the elastic Reissner's membrane as well as a wave of deformation of the cochlear bone. Each mode can explain a distinct component of otoacoustic emissions. The cochlear-bone deformation can also underlie bone conduction, the phenomenon by which we can hear a vibration of the skull as sound.

  • Conference paper
    Grigoriadis G, Newell N, Masouros SD, Bull AMJet al., 2014,

    The material properties of the human heel fat pad across strain-rates: An inverse finite element approach

    , Pages: 478-479
  • Conference paper
    Wilgeroth JM, Nguyen T-TN, Proud WG, 2014,

    Interaction between blast wave and reticulated foam: assessing the potential for auditory protection systems

    , 18th Joint Int Conf of the APS Topical-Grp on Shock Compress of Condensed Matter / 24th Int Conf of the Int-Assoc-for-the-Advancement-of-High-Pressure-Sci-and-Technol, Publisher: IOP PUBLISHING LTD, ISSN: 1742-6588
  • Conference paper
    Butler BJ, Bo C, Tucker AW, Jardine AP, Proud WG, Williams A, Brown KAet al., 2014,

    Mechanical and histological characterization of trachea tissue subjected to blast-type pressures

    , 18th Joint Int Conf of the APS Topical-Grp on Shock Compress of Condensed Matter / 24th Int Conf of the Int-Assoc-for-the-Advancement-of-High-Pressure-Sci-and-Technol, Publisher: IOP PUBLISHING LTD, ISSN: 1742-6588
  • Conference paper
    Nguyen T-TN, Wilgeroth JM, Proud WG, 2014,

    Controlling blast wave generation in a shock tube for biological applications

    , 18th Joint Int Conf of the APS Topical-Grp on Shock Compress of Condensed Matter / 24th Int Conf of the Int-Assoc-for-the-Advancement-of-High-Pressure-Sci-and-Technol, Publisher: IOP PUBLISHING LTD, ISSN: 1742-6588
  • Conference paper
    Khan AS, Balzer JE, Wilgeroth JM, Proud WGet al., 2014,

    Aspect ratio compression effects on metals and polymers

    , 18th Joint Int Conf of the APS Topical-Grp on Shock Compress of Condensed Matter / 24th Int Conf of the Int-Assoc-for-the-Advancement-of-High-Pressure-Sci-and-Technol, Publisher: IOP PUBLISHING LTD, ISSN: 1742-6588
  • Conference paper
    Proud WG, 2014,

    Gas percolation through sand

    , 18th Joint Int Conf of the APS Topical-Grp on Shock Compress of Condensed Matter / 24th Int Conf of the Int-Assoc-for-the-Advancement-of-High-Pressure-Sci-and-Technol, Publisher: IOP PUBLISHING LTD, ISSN: 1742-6588
  • Conference paper
    Bo C, Williams A, Rankin S, Proud WG, Brown KAet al., 2014,

    Integrated experimental platforms to study blast injuries: a bottom-up approach

    , 18th Joint Int Conf of the APS Topical-Grp on Shock Compress of Condensed Matter / 24th Int Conf of the Int-Assoc-for-the-Advancement-of-High-Pressure-Sci-and-Technol, Publisher: IOP PUBLISHING LTD, ISSN: 1742-6588
  • Conference paper
    Villette C, Modenese L, Phillips ATM, 2014,

    Combined finite element and musculoskeletal predictive structural modelling of the femur: Potential mechanobiology applications

  • Journal article
    Prinold JAI, Villette CC, Bull AMJ, 2013,

    The influence of extreme speeds on scapula kinematics and the importance of controlling the plane of elevation

    , CLINICAL BIOMECHANICS, Vol: 28, Pages: 973-980, ISSN: 0268-0033
  • Journal article
    Harris K, Armstrong SP, Campos-Pires R, Kiru L, Franks NP, Dickinson Ret al., 2013,

    Neuroprotection against traumatic brain injury by xenon but not argon, is mediated by inhibition at the NMDA receptor glycine site

    , Anesthesiology, Vol: 119, Pages: 1137-1148, ISSN: 1528-1175

    Background. The inert anesthetic gas xenon is neuroprotective in models of brain injury. Weinvestigate the neuroprotective mechanisms of the inert gases xenon, argon, krypton, neon andhelium in an in vitro model of traumatic brain injury.Methods. We use an in vitro model using mouse organotypic hippocampal brain-slices, subjectedto a focal mechanical trauma, with injury quantified by propidium-iodide fluorescence. Patch-clampelectrophysiology is used to investigate the effect of the inert gases on N-methyl-D-aspartate(NMDA)-receptors and TREK-1 channels, two molecular targets likely to play a role inneuroprotection.Results. Xenon(50%) and, to a lesser extent, argon(50%) are neuroprotective against traumaticinjury when applied following injury [xenon 43±1% protection 72hours after injury (N=104); argon30±6% protection (N=44); mean±SEM]. Helium, neon and krypton are devoid of neuroprotectiveeffect. Xenon(50%) prevents development of secondary injury up to 48 hours after trauma.Argon(50%) attenuates secondary injury, but is less effective than xenon [xenon 50±5% reductionin secondary injury 72hours after injury (N=104); argon 34±8% reduction (N=44); mean±SEM].Glycine reverses the neuroprotective effect of xenon, but not argon, consistent with competitiveinhibition at the NMDA receptor glycine-site mediating xenon neuroprotection against traumaticbrain injury. Xenon inhibits NMDA receptors and activates TREK-1 channels, while argon,krypton, neon and helium have no effect on these ion-channels.Conclusions. Xenon neuroprotection against traumatic brain injury can be reversed by elevatingthe glycine concentration, consistent with inhibition at the NMDA-receptor glycine site playing asignificant role in xenon neuroprotection. Argon and xenon do not act via the same mechanism.

  • Journal article
    Masouros SD, Newell N, Ramasamy A, Bonner TJ, West ATH, Hill AM, Clasper JC, Bull AMJet al., 2013,

    Design of a Traumatic Injury Simulator for Assessing Lower Limb Response to High Loading Rates

    , ANNALS OF BIOMEDICAL ENGINEERING, Vol: 41, Pages: 1957-1967, ISSN: 0090-6964
  • Journal article
    Masouros SD, Brown KA, Clasper J, Proud WGet al., 2013,

    Briefing: Blast effects on biological systems

    , Proceedings of the Institution of Civil Engineers: Engineering and Computational Mechanics, Vol: 166, Pages: 113-118, ISSN: 1755-0777

    A signature of current conflicts is the use of buried improvised explosive devices to cause injury to military personnel and damage to their vehicles. Explosive devices also cause injuries to non-military populations in current and former conflict zones. The nature and placement of the explosive charge has a marked effect on the loading experienced. In all situations, damage to tissues occurs when the energy and loading rate exceeds that which the human body can support. Currently, it is difficult to predict the various time-dependent effects of blast injury because of the complexities of the rapid initial accelerations, the loading geometries and the heterogeneous nature of the tissues that can be damaged. An outline of the ways in which one may study how explosive energy interacts with biological systems is presented along with a discussion of how the data generated can be used to develop improved, costeffective strategies for studying blast injury processes.

  • Conference paper
    Villette CC, Thibon A, Modenese L, Phillips ATMet al., 2013,

    Combined musculoskeletal and finite element modelling of the femur

    , International Society of Biomechanics

    In the 1870’s, Wolff formulated a ‘trajectory theory’ about trabecular bone architecture which can be succinctly written as follows: bone adapts its structure to loading conditions in a way that follows principal stress trajectories. In this study, it was assumed that the human femur is optimally adapted to the loading conditions experienced during daily activities such as walking or climbing stairs. Hence, an initially randomized structural mesoscale model of a femur was iteratively adapted to the loading conditions experienced during a range of daily activities. The resulting structure shows a good visual comparison with clinical observation and the model proved computationally efficient.

  • Conference paper
    Gopalakrishnan A, Modenese L, Phillips ATM, 2013,

    Generating computer simulations of movement using muscle synergy inputs

    , International Society of Biomechanics
  • Conference paper
    Modenese L, Gopalakrishnan A, Lloyd DG, Phillips ATMet al., 2013,

    Falsification of a lower limb model predicting hip contact force vectors

    , International Society of Biomechanics
  • Journal article
    Singleton JAG, Gibb IE, Bull AMJ, Mahoney PF, Clasper JCet al., 2013,

    Primary blast lung injury prevalence and fatal injuries from explosions: Insights from postmortem computed tomographic analysis of 121 improvised explosive device fatalities

    , JOURNAL OF TRAUMA AND ACUTE CARE SURGERY, Vol: 75, Pages: S269-S274, ISSN: 2163-0755

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