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Mechanisms of Circadian Dysfunction in Ageing & Neurodegeneration

Working to identify the molecular mechanisms, cellular players and emergent network interactions driving circadian and sleep function, and their disruption in the early stages of Alzheimer’s disease

HI

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Research

Read more about our work using live imaging and in vivo gene therapy techniques to investigate the role circadian rhythms play in dementia
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Lab members

Meet our team of researchers, past and present

Opportunities

We are always keen to hear from talented scientists interested in joining our lab - get in touch today!

Featured news

  • In the media
  • December 2025
The ‘silent’ brain cells that shape our behaviour, memory and health

New article in Nature discusses discoveries made studying astrocytes - the previously overlooked support cells in the brain
  • In the media
  • January 2025
Research from the Brancaccio lab featured in Heliox podcast

The episode dived into the role of astrocytes and their production of GABA in orchestrating our internal clocks
Woman holds her hand up to her mouth and yawns
  • Research
  • December 2024
New paper reveals ‘chemical metronome’ helps the brain to keep time

Researchers led by Dr Marco Brancaccio, have uncovered a ‘chemical metronome’ in the brain, which helps to synchronise our sleeping patterns
  • Research
  • April 2024
How temperature and circadian rhythms intersect to regulate a protective protein

New study led by Dr Marco Brancaccio offers a deeper insight into how a neuroprotective pathway is regulated

Faculty of Medicine news

All News
  • news

Students learn power of patient and public voices in surgical research

11 November 2025
  • news

New trial explores improved vaccine responses in patients with IBD

07 November 2025
  • news

Department of Metabolism Digestion & Reproduction celebrates Silver Athena award

27 October 2025

24 October 2025

Imperial designated Focused Ultrasound Centre of Excellence

23 October 2025

Health minister visits Imperial-hosted Tommy's research centre

20 October 2025

New small molecule locks out antibiotic efflux in MRSA