BibTex format
@article{Brady:2023:10.1016/j.chom.2023.11.003,
author = {Brady, A and Cabello-Yeves, E and Gallego, Del Sol F and Chmielowska, C and Mancheño-Bonillo, J and Zamora-Caballero, S and Omer, SB and Torres-Puente, M and Eldar, A and Quiles-Puchalt, N and Marina, A and Penadés, JR},
doi = {10.1016/j.chom.2023.11.003},
journal = {Cell Host and Microbe},
pages = {2023--2037.e8},
title = {Characterization of a unique repression system present in arbitrium phages of the SPbeta family},
url = {http://dx.doi.org/10.1016/j.chom.2023.11.003},
volume = {31},
year = {2023}
}
RIS format (EndNote, RefMan)
TY - JOUR
AB - Arbitrium-coding phages use peptides to communicate and coordinate the decision between lysis and lysogeny. However, the mechanism by which these phages establish lysogeny remains unknown. Here, focusing on the SPbeta phage family's model phages phi3T and SPβ, we report that a six-gene operon called the "SPbeta phages repressor operon" (sro) expresses not one but two master repressors, SroE and SroF, the latter of which folds like a classical phage integrase. To promote lysogeny, these repressors bind to multiple sites in the phage genome. SroD serves as an auxiliary repressor that, with SroEF, forms the repression module necessary for lysogeny establishment and maintenance. Additionally, the proteins SroABC within the operon are proposed to constitute the transducer module, connecting the arbitrium communication system to the activity of the repression module. Overall, this research sheds light on the intricate and specialized repression system employed by arbitrium SPβ-like phages in making lysis-lysogeny decisions.
AU - Brady,A
AU - Cabello-Yeves,E
AU - Gallego,Del Sol F
AU - Chmielowska,C
AU - Mancheño-Bonillo,J
AU - Zamora-Caballero,S
AU - Omer,SB
AU - Torres-Puente,M
AU - Eldar,A
AU - Quiles-Puchalt,N
AU - Marina,A
AU - Penadés,JR
DO - 10.1016/j.chom.2023.11.003
EP - 2037
PY - 2023///
SN - 1931-3128
SP - 2023
TI - Characterization of a unique repression system present in arbitrium phages of the SPbeta family
T2 - Cell Host and Microbe
UR - http://dx.doi.org/10.1016/j.chom.2023.11.003
UR - https://www.ncbi.nlm.nih.gov/pubmed/38035880
VL - 31
ER -