In this section
@article{Michie:2014:10.1371/journal.pone.0107211,
author = {Michie, KA and Boysen, A and Low, HH and Moller-Jensen, J and Loewe, J},
doi = {10.1371/journal.pone.0107211},
journal = {PLoS One},
pages = {1--10},
title = {LeoA, B and C from enterotoxigenic escherichia coli (ETEC) are bacterial dynamins},
url = {http://dx.doi.org/10.1371/journal.pone.0107211},
volume = {9},
year = {2014}
}
TY - JOUR
AB - Escherichia coli (ETEC) strain H10407 contains a GTPase virulence factor, LeoA, which is encoded on a pathogenicity island and has been shown to enhance toxin release, potentially through vesicle secretion. By sequence comparisons and X-ray structure determination we now identify LeoA as a bacterial dynamin-like protein (DLP). Proteins of the dynamin family remodel membranes and were once thought to be restricted to eukaryotes. In ETEC H10407 LeoA localises to the periplasm where it forms a punctate localisation pattern. Bioinformatic analyses of leoA and the two upstream genes leoB and leoC suggest that LeoA works in concert with a second dynamin-like protein, made up of LeoB and LeoC. Disruption of the leoAB genes leads to a reduction in secretion of periplasmic Tat-GFP and outer membrane OmpA. Our data suggest a role for LeoABC dynamin-like proteins in potentiating virulence through membrane vesicle associated toxin secretion.
AU - Michie,KA
AU - Boysen,A
AU - Low,HH
AU - Moller-Jensen,J
AU - Loewe,J
DO - 10.1371/journal.pone.0107211
EP - 10
PY - 2014///
SN - 1932-6203
SP - 1
TI - LeoA, B and C from enterotoxigenic escherichia coli (ETEC) are bacterial dynamins
T2 - PLoS One
UR - http://dx.doi.org/10.1371/journal.pone.0107211
UR - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000342684500075&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR - https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0107211
UR - http://hdl.handle.net/10044/1/82081
VL - 9
ER -
Join us for our Open Day on 16 May 2024 - find out more!
