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• Journal article
  Busch GK, Tate EW, Gaffney PR, Rosivatz E, Woscholski R, Leatherbarrow RJet al., 2008,

  Specific N-terminal protein labelling: use of FMDV 3C pro protease and native chemical ligation

  , Chem.Commun.(Camb.), Pages: 3369-3371

  We report an effective strategy for generating N-terminal cysteinyl proteins by proteolytic cleavage using the enzyme 3C pro, suitable for a wide range of applications via native chemical ligation

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• Conference paper
  Owen DM, Manning HB, de Beule P, Talbot C, Requejo-Isidro J, Dunsby C, McGinty J, Benninger RKP, Elson DS, Munro I, Galletly NP, Lever MJ, Stamp GW, Anand P, Neil MAA, French PMWet al., 2007,

  Development of a hyperspectral fluorescence lifetime imaging microscope and its application to tissue imaging

  , Conference on Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues V, Publisher: SPIE-INT SOC OPTICAL ENGINEERING, ISSN: 0277-786X
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  • Citations: 2
• Journal article
  Rosivatz E, Matthews JG, McDonald NQ, Mulet X, Ho KK, Lossi N, Schmid AC, Mirabelli M, Pomeranz KM, Erneux C, Lam EW, Vilar R, Woscholski Ret al., 2006,

  A small molecule inhibitor for phosphatase and tensin homologue deleted on chromosome 10 (PTEN)

  , ACS Chem.Biol., Vol: 1, Pages: 780-790

  Phosphatase and tensin homologue deleted on chromosome 10 (PTEN), a phosphoinositide 3-phosphatase, is an important regulator of insulin-dependent signaling. The loss or impairment of PTEN results in an antidiabetic impact, which led to the suggestion that PTEN could be an important target for drugs against type II diabetes. Here we report the design and validation of a small- molecule inhibitor of PTEN. Compared with other cysteine-based phosphatases, PTEN has a much wider active site cleft enabling it to bind the PtdIns(3,4,5)P3 substrate. We have exploited this feature in the design of vanadate scaffolds complexed to a range of different organic ligands, some of which show potent inhibitory activity. A vanadyl complexed to hydroxypicolinic acid was found to be a highly potent and specific inhibitor of PTEN that increases cellular PtdIns(3,4,5)P3 levels, phosphorylation of Akt, and glucose uptake in adipocytes at nanomolar concentrations. The findings presented here demonstrate the applicability of a novel and specific chemical inhibitor against PTEN in research and drug development

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• Journal article
  Conn C, Ces O, Mulet X, Sebai S, Shearman G, Heron A, Seddon J M, Squires A, Finet S, Kraineva J, Winter R, Templer R Het al., 2006,

  Dynamics of structural transformations between lamellar and inverse bicontinuous cubic lyotropic phases

  , Physical Review Letters, Pages: 108102-1-108102-4
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• Journal article
  Clay EH, Gould IR, 2005,

  A combined QM and MM investigation into guanine quadruplexes

  , JOURNAL OF MOLECULAR GRAPHICS & MODELLING, Vol: 24, Pages: 138-146, ISSN: 1093-3263
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  • Citations: 21

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