In this section
@article{Honey:1990:10.1097/00001756-199011000-00019,
author = {Honey, CR and Clarke, DJ and Dallman, MJ and Charlton, HM},
doi = {10.1097/00001756-199011000-00019},
journal = {Neuroreport},
pages = {247--249},
title = {Human neural graft function in rats treated with anti-interleukin II receptor antibody.},
url = {http://dx.doi.org/10.1097/00001756-199011000-00019},
volume = {1},
year = {1990}
}
TY - JOUR
AB - Prolonged immunosuppression with cyclosporin A allows survival of human xenografts in the rat Parkinsonian model but the drug has side effects. Ideally immunosuppression should be of short duration, to minimize the chance of infection, yet be capable of supporting long term survival of the transplanted tissue. We report that short term treatment with an anti-rat interleukin II receptor (IL2R) monoclonal antibody (MAb) resulted in apparently permanent survival of human fetal dopaminergic grafts in "Parkinsonian" rats. The recipients remained healthy and the excellent survival of the transplants suggests that the antibody injection strategy would almost certainly abrogate allograft rejection and raises the possibility that xenogenic dopaminergic neurones could be used as donor tissue in humans.
AU - Honey,CR
AU - Clarke,DJ
AU - Dallman,MJ
AU - Charlton,HM
DO - 10.1097/00001756-199011000-00019
EP - 249
PY - 1990///
SN - 0959-4965
SP - 247
TI - Human neural graft function in rats treated with anti-interleukin II receptor antibody.
T2 - Neuroreport
UR - http://dx.doi.org/10.1097/00001756-199011000-00019
UR - https://www.ncbi.nlm.nih.gov/pubmed/1983357
VL - 1
ER -