In this section

UKFSST publications

2022

Juul FE, Cross AJ, Schoen RE, Senore C, Pinsky P, Miller E, Segnan N, Wooldrage K, Wieszczy-Szczepanik P, Armaroli P, Garborg KK, Adami H-O, Hoff G, Kalager M, Bretthauer M, Loberg M, Holme O. 15-Year Benefits of Sigmoidoscopy Screening on Colorectal Cancer Incidence and Mortality: A Pooled Analysis of Randomized Trials. Ann Intern Med. 2022;175:1525-1533. DOI:10.7326/M22-0835.

Cross AJ*, Robbins EC, Saunders BP, Duffy SW, Wooldrage K. Higher Adenoma Detection Rates at Screening Associated With Lower Long-Term Colorectal Cancer Incidence and Mortality. Clin Gastroenterol Hepatol. 2022 Feb;20(2):e148-e167. DOI: 10.1016/j.cgh.2020.09.020.

2021

Robbins EC, Wooldrage K, Stenson I, Pack K, Duffy S, Weller D, Levin T, Conell C, Wright S, Nickerson C, Martin J, Cross AJ*. Heterogeneity in colorectal cancer incidence among people recommended 3-yearly surveillance post-polypectomy: a validation study. Endoscopy. 2021 Apr;53(4):402-410. DOI: 10.1055/a-1217-0155.

Brenner H*, Cross AJ. Merits, Challenges, and Limitations of Randomized Trials on Colorectal Cancer Screening Effectiveness. Gastroenterology. 2021 Mar;160(4):1009-1011. DOI: 10.1053/j.gastro.2020.12.029.

2020

Robbins EC*, Wooldrage K, Saunders BP, Duffy SW, Cross AJ. P22 (Poster) Impact of adenoma detection rates at flexible sigmoidoscopy on long-term colorectal cancer incidence and mortality. BSG Virtual campus conference Jan 2021. DOI:10.1136/gutjnl-2020-bsgcampus.97.

Cross AJ*, Robbins EC, Saunders BP, Duffy SW, Wooldrage K. Higher adenoma detection rates at screening associated with lower long-term colorectal cancer incidence and mortality. Clin Gastroenterol Hepatol. 2020 Sep 12:S1542-3565(20)31280-5. DOI: 10.1016/j.cgh.2020.09.020.

2018

Pinsky PF*, Loberg M, Senore C, Wooldrage K, Atkin W, Bretthauer M, Cross AJ, Hoff G, Holme O, Kalager M, Segnan N, Schoen RE. Number of Adenomas Removed and Colorectal Cancers Prevented in Randomized Trials of Flexible Sigmoidoscopy Screening. Gastroenterology. 2018 Jun 20. pii: S0016-5085(18)34667-5. DOI: 10.1053/j.gastro.2018.06.040.

Brown JP*, Wooldrage K, Kralj-Hans I, Wright S, Cross AJ, Atkin WS. Effect of once-only flexible sigmoidoscopy screening on the outcomes of subsequent faecal occult blood test screening. J Med Screen. 2018 Oct 3:969141318785654. DOI: 10.1177/0969141318785654.

2017

Atkin W*, Wooldrage K, Parkin DM, Kralj-Hans I, MacRae E, Shah U, Duffy S, Cross AJ. Long term effects of once-only flexible sigmoidoscopy screening after 17 years of follow-up: the UK Flexible Sigmoidoscopy Screening randomised controlled trial. Lancet. 2017 Apr 1;389(10076):1299-1311. DOI: 10.1016/S0140-6736(17)30396-3.

2016

McGregor LM, Bonello B, Kerrison RS, Nickerson C, Baio G, Berkman L, Rees CJ, Atkin W, Wardle J, von Wagner C*. Uptake of Bowel Scope (Flexible Sigmoidoscopy) Screening in the English National Programme: the first 14 months. J Med Screen. 2016 Jun;23(2):77-82. DOI: 10.1177/0969141315604659.

2014

von Wagner C, Bowyer H, Rees CJ, Atkin W, Wardle J. Patient-reported Experience Of Comfort And Dignity In Flexible Sigmoidoscopy: Data From The Nhs Bowel Scope Screening Pilot. Gut 2014;63:A137. DOI: 10.1136/gutjnl-2014-307263.294.

2012

Robb KA, Lo SH, Power E, Kralj-Hans I, Edwards R, Vance M, von Wagner C, Atkin W, Wardle J. Patient-reported outcomes following flexible sigmoidoscopy screening for colorectal cancer in a demonstration screening programme in the UK. J Med Screen. 2012 Dec;19(4):171-6. DOI: 10.1258/jms.2012.012129.

2011

Segnan N, Armaroli P, Bonelli L, Risio M, Sciallero S, Zappa M, Andreoni B, Arrigoni A, Bisanti L, Casella C, Crosta C, Falcini F, Ferrero F, Giacomin A, Giuliani O, Santarelli A, Visioli CB, Zanetti R, Atkin WS, Senore C; SCORE Working Group. Once-only sigmoidoscopy in colorectal cancer screening: follow-up findings of the Italian Randomized Controlled Trial–SCORE. J Natl Cancer Inst. 2011 Sep 7;103(17):1310-22. DOI: 10.1093/jnci/djr284. Erratum in: J Natl Cancer Inst. 2011 Dec 21;103(24):1903. Fracchia, M [added].

Robb KA, Smith SG, Power E, Kralj-Hans I, Vance M, Wardle J, Atkin W. Nurses’ experiences of a colorectal cancer screening pilot. Br J Nurs. 2011 Feb 24-Mar 9;20(4):210, 212, 214 passim. DOI: 10.12968/bjon.2011.20.4.210.

2010

Atkin W, Kralj-Hans I, Wardle J, Duffy S. Colorectal cancer screening. Randomised trials of flexible sigmoidoscopy. BMJ. 2010 Aug 24;341:c4618. DOI: 10.1136/bmj.c4618.

Atkin WS, Edwards R, Kralj-Hans I, Wooldrage K, Hart AR, Northover JM, Parkin DM, Wardle J, Duffy SW, Cuzick J; UK Flexible Sigmoidoscopy Trial Investigators. Once-only flexible sigmoidoscopy screening in prevention of colorectal cancer: a multicentre randomised controlled trial. Lancet. 2010 May 8;375(9726):1624-33. DOI: 10.1016/S0140-6736(10)60551-X.

Robb K, Power E, Kralj-Hans I, Edwards R, Vance M, Atkin W, Wardle J. Flexible sigmoidoscopy screening for colorectal cancer: uptake in a population-based pilot programme. J Med Screen. 2010;17(2):75-8. DOI: 10.1258/jms.2010.010055.

Wardle J, Atkin W. Colorectal cancer prevention through screening: population acceptance of flexible sigmoidoscopy. J Med Screen. 2010;17(2):56-7. DOI: 10.1258/jms.2010.010062.

2009

Austin KL, Power E, Solarin I, Atkin WS, Wardle J, Robb KA. Perceived barriers to flexible sigmoidoscopy screening for colorectal cancer among UK ethnic minority groups: a qualitative study. J Med Screen. 2009;16(4):174-9. DOI: 10.1258/jms.2009.009080.

Miles A, Atkin WS, Kralj-Hans I, Wardle J. The psychological impact of being offered surveillance colonoscopy following attendance at colorectal screening using flexible sigmoidoscopy. J Med Screen. 2009;16(3):124-30. DOI: 10.1258/jms.2009.009041.

2008

Thompson MR, Flashman KG, Wooldrage K, Rogers PA, Senapati A, O’Leary DP, Atkin W. Flexible sigmoidoscopy and whole colonic imaging in the diagnosis of cancer in patients with colorectal symptoms. Br J Surg. 2008 Sep;95(9):1140-6. DOI: 10.1002/bjs.6234.

Power E, Van Jaarsveld CH, McCaffery K, Miles A, Atkin W, Wardle J. Understanding intentions and action in colorectal cancer screening. Ann Behav Med. 2008 Jun;35(3):285-94. DOI: 10.1007/s12160-008-9034-y.

Robb KA, Power E, Atkin W, Wardle J. Ethnic differences in participation in flexible sigmoidoscopy screening in the UK. J Med Screen. 2008;15(3):130-6. DOI: 10.1258/jms.2008.007112.

Benson VS, Patnick J, Davies AK, Nadel MR, Smith RA, Atkin WS; International Colorectal Cancer Screening Network. Colorectal cancer screening: a comparison of 35 initiatives in 17 countries. Int J Cancer. 2008 Mar 15;122(6):1357-67. DOI: 10.1002/ijc.23273.

Robb KA, Solarin I, Power E, Atkin W, Wardle J. Attitudes to colorectal cancer screening among ethnic minority groups in the UK. BMC Public Health. 2008 Jan 25;8:34. DOI: 10.1186/1471-2458-8-34.

2007

Tomlinson I, Webb E, Carvajal-Carmona L, Broderick P, Kemp Z, Spain S, Penegar S, Chandler I, Gorman M, Wood W, Barclay E, Lubbe S, Martin L, Sellick G, Jaeger E, Hubner R, Wild R, Rowan A, Fielding S, Howarth K; CORGI Consortium, Silver A, Atkin W, Muir K, Logan R, Kerr D, Johnstone E, Sieber O, Gray R, Thomas H, Peto J, Cazier JB, Houlston R. A genome-wide association scan of tag SNPs identifies a susceptibility variant for colorectal cancer at 8q24.21. Nat Genet. 2007 Aug;39(8):984-8. DOI: 10.1038/ng2085.

Mitrou PN, Watson MA, Loktionov AS, Cardwell C, Gunter MJ, Atkin WS, Macklin CP, Cecil T, Bishop DT, Primrose J, Bingham SA. Role of NQO1C609T and EPHX1 gene polymorphisms in the association of smoking and alcohol with sporadic distal colorectal adenomas: results from the UKFSS Study. Carcinogenesis. 2007 Apr;28(4):875-82. DOI: 10.1093/carcin/bgl194.

Brotherstone H, Vance M, Edwards R, Miles A, Robb KA, Evans RE, Wardle J, Atkin W. Uptake of population-based flexible sigmoidoscopy screening for colorectal cancer: a nurse-led feasibility study. J Med Screen. 2007;14(2):76-80. DOI: 10.1258/096914107781261972.

2006

Mitrou PN, Watson MA, Loktionov AS, Cardwell C, Gunter MJ, Atkin WS, Macklin CP, Cecil T, Bishop TD, Primrose J, Bingham SA. MTHFR (C677T and A1298C) polymorphisms and risk of sporadic distal colorectal adenoma in the UK Flexible Sigmoidoscopy Screening Trial (United Kingdom). Cancer Causes Control. 2006 Aug;17(6):793-801. DOI: 10.1007/s10552-006-0016-8.

Thomas-Gibson S, Rogers, PA, Cooper S, Man R, Rutter MD, Suzuki N, Swain D, Thuraisingam A, Atkin W. Judgement of quality of bowel preparation at screening flexible sigmoidoscopy is associated with variability in adenoma detection rates. Endoscopy. 2006 May;38(5):456-60. DOI: 10.1055/s-2006-925259.

Thomas-Gibson S, Saunders BP, Suzuki N, Vance M, Rutter M, Swain D, Thapar C, Quraishy S, Nicholls A, Atkin WS. Development of a Video Assessment scoring method to determine the accuracy of Endoscopist performance at screening flexible sigmoidoscopy. Endoscopy. 2006 Mar;38(3):218-25. DOI: 10.1055/s-2005-870445.

Bonelli L, Sciallero S, Senore C, Zappa M, Aste H, Andreoni B, Angioli D, Ferraris R, Gasperoni S, Malfitana G, Pennazio M, Atkin W, Segnan N; SCORE Working Group. History of negative colorectal endoscopy and risk of rectosigmoid neoplasms at screening flexible sigmoidoscopy. Int J Colorectal Dis. 2006 Mar;21(2):105-13. DOI: 10.1007/s00384-005-0775-9.

2005

Wardle J, Miles A, Atkin W. Gender differences in utilization of colorectal cancer screening. J Med Screen. 2005;12(1):20-7. DOI: 10.1258/0969141053279158.

Levin TR, Atkin WS. Colonoscopic screening of women for colorectal neoplasia. N Engl J Med. 2005 Aug 25;353(8):844-6; author reply 844-6. DOI: 10.1056/NEJMc051651.

Gunter MJ, Watson MA, Loktionov AS, Mitrou P, Cecil T, Macklin C, Cardwell C, Bishop DT, Primrose J, Atkin WS, Bingham SA. No association between cytochrome P450 and glutathione S-transferase gene polymorphisms and risk of colorectal adenoma: results from the UK Flexible Sigmoidoscopy Screening Trial. Cancer Epidemiol Biomarkers Prev. 2005 Apr;14(4):1028-30. DOI: 10.1158/1055-9965.EPI-04-0740.

Levin TR, Farraye FA, Schoen RE, Hoff G, Atkin WS, Bond JH, Winawer SJ, Burt RW, Johnson DA, Kirk LM, Litin SC, Rex DK. Quality in the technical performance of screening flexible sigmoidoscopy: recommendations of an international multi-society task group. Gut. 2005 Jun;54(6):807-13. DOI: 10.1136/gut.2004.052282.

Johnson V, Volikos E, Halford S, Eftekhar Sadat A, Popat S, Talbot I, Truninger K, Martin J, Jass J, Houlston R, Atkin W, Tomlinson I, and Silver A. Exon 3 beta-catenin mutations are specifically associated with colorectal carcinomas in the hereditary non-polyposis colorectal cancer syndrome. Gut. 2005 Feb;54(2):264-7. DOI: 10.1136/gut.2004.048132.

2004

Wardle J, McCaffery K, Nadel M, Atkin W. Socioeconomic differences in cancer screening participation: comparing cognitive and psychosocial explanations. Soc Sci Med. 2004 Jul;59(2):249-61. doi: 10.1016/j.socscimed.2003.10.030. DOI: 10.1016/j.socscimed.2003.10.030.

Ferraris R, Senore C, Fracchia M, Sciallero S, Bonelli L, Atkin WS, Segnan N and the SCORE working group Italy. Predictive value of rectal bleeding for distal colonic neoplastic lesions in a screening population. Eur J Cancer. 2004 Jan;40(2):245-52. DOI: 10.1016/j.ejca.2003.08.002.

Atkin W, Rogers P, Cardwell C, Cook C, Cuzick J, Wardle J, Edwards R. Wide variation in adenoma detection rates at screening flexible sigmoidoscopy. Gastroenterology. 2004 May;126(5):1247-56. DOI: 10.1053/j.gastro.2004.01.023.

2003

Miles A, Wardle J, Atkin W. Receiving a screen-detected diagnosis of cancer: the experience of participants in the UK flexible sigmoidoscopy trial. Psychooncology. 2003 Dec;12(8):784-802. DOI: 10.1002/pon.705.

Miles A, Wardle J, McCaffery K, Williamson S, Atkin W. The effects of colorectal cancer screening on health attitudes and practices. Cancer Epidemiol Biomarkers Prev. 2003 Jul;12(7):651-5.

Adams C, Cardwell C, Cook C, Edwards R, Atkin WS, Morton DG. Effect of hysterectomy status on polyp detection rates at screening flexible sigmoidoscopy. Gastrointest Endosc. 2003 Jun;57(7):848-53. DOI: 10.1016/s0016-5107(03)70019-4.

Whynes DK, Frew EJ, Edwards R, Atkin WS. Costs of flexible sigmoidoscopy screening for colorectal cancer in the United Kingdom. Int J Technol Assess Health Care. 2003 Spring;19(2):384-95. DOI: 10.1017/s0266462303000345.

Wardle J, Williamson S, McCaffery K, Sutton S, Taylor T, Edwards R, Atkin W. Increasing attendance at colorectal cancer screening: testing the efficacy of a mailed, psychoeducational intervention in a community sample of older adults. Health Psychol. 2003 Jan;22(1):99-105. DOI: 10.1037//0278-6133.22.1.99.

Wardle J, Williamson S, Sutton S, Biran A, McCaffery K, Cuzick J, Atkin W. Psychological impact of colorectal cancer screening. Health Psychol. 2003 Jan;22(1):54-9. DOI: 10.1037//0278-6133.22.1.54.

2002

Segnan N, Senore C, Andreoni B, Aste H, Bonelli L, Crosta C, Ferraris R, Gasperoni S, Penna A, Risio M, Rossini FP, Sciallero S, Zappa M, Atkin WS; SCORE Working Group–Italy. Baseline findings of the Italian multicenter randomized controlled trial of “once-only sigmoidoscopy”–SCORE. J Natl Cancer Inst. 2002 Dec 4;94(23):1763-72. DOI: 10.1093/jnci/94.23.1763.

McCaffery K, Wardle J, Nadel M, Atkin W. Socioeconomic variation in participation in colorectal cancer screening. J Med Screen. 2002;9(3):104-8. DOI: 10.1136/jms.9.3.104.

Atkin WS, Cook C, Cuzick J, Edwards R, Northover JMA, Wardle J and the UK Flexible Sigmoidoscopy Screening Trial Investigators. Single flexible sigmoidoscopy screening to prevent colorectal cancer; baseline findings of a UK multicentre randomised trial. Lancet. 2002 Apr 13;359(9314):1291-300. DOI: 10.1016/S0140-6736(02)08268-5.

Leuratti C, Watson MA, Deag EJ, Welch A, Singh R, Gottschalg E, Marnett LJ, Atkin W, Day NE, Shuker DE, Bingham SA Detection of malondialdehyde DNA adducts in human colorectal mucosa: relationship with diet and the presence of adenomas. Cancer Epidemiol Biomarkers Prev. 2002 Mar;11(3):267-73.

2001

Atkin WS, Edwards R, Wardle J, Northover JMA, Sutton S, Hart AR, Williams CB, Cuzick J. Design of a multicentre randomised trial to evaluate flexible sigmoidoscopy in colorectal cancer screening. J Med Screen. 2001;8(3):137-44. DOI: 10.1136/jms.8.3.137.

Renehan AG, Painter JE, Atkin WS, Shalet SM, O’Dwyer ST. High-risk colorectal adenomas and serum insulin-like growth factors. Br J Surg. 2001 Jan;88(1):107-13. DOI: 10.1046/j.1365-2168.2001.01645.x.

Hanson JM, Atkin WS, Cunliffe WJ, Browell DA, Griffith CDM, Varma JS, Plusa SM. Rectal retroflexion: an essential part of lower gastrointestinal endoscopic examination. Dis Colon Rectum. 2001 Nov;44(11):1706-8. DOI: 10.1007/BF02234394.

McCaffery K, Borrill J, Williamson S, Taylor T, Sutton S, Atkin W, Wardle J. Declining the offer of flexible sigmoidoscopy screening for bowel cancer: a qualitative investigation of the decision-making process. Soc Sci Med. 2001 Sep;53(5):679-91. DOI: 10.1016/s0277-9536(00)00375-0.

2000

Wardle J, Sutton S, Williamson S, Taylor T, McCaffery K, Cuzick J, Hart A, Atkin WS. Psychosocial influences on older adults interest in participating in bowel cancer screening. Prev Med. 2000 Oct;31(4):323-34. DOI: 10.1006/pmed.2000.0725.

Sutton S, Wardle J, Taylor T, McCaffery K, Williamson S, Edwards R, Cuzick J, Hart A, Northover J, Atkin W. Predictors of attendance in the UK flexible sigmoidoscopy screening trial. J Med Screen. 2000;7(2):99-104. DOI: 10.1136/jms.7.2.99.

Rex D, Atkin W, Hoff G, Waye J. The flexible sigmoidoscope. Gastrointest Endosc. 2000 Oct;52(4):587-9. DOI: 10.1067/mge.2000.108522.

Renehan AG, Painter JE, O’Halloran D, Atkin WS, Potten CS, O’Dwyer ST, Shalet SM. Circulating insulin-like growth factor (IGF)-II and colorectal adenomas. J Clin Endocrinol Metab. 2000 Sep;85(9):3402-8. DOI: 10.1210/jcem.85.9.6770.

Martin JP, Sexton BF, Saunders BP, Atkin WS. Inhaled patient-administered nitrous oxide/oxygen mixture does not impair driving ability when used as analgesia during screening flexible sigmoidoscopy. Gastrointest Endosc. 2000 Jun;51(6):701-3. DOI: 10.1067/mge.2000.106113.

Taylor T, Williamson S, Wardle J, Borrill. J, Sutton S, Atkin W. Acceptability of flexible sigmoidoscopy screening in older adults in the UK. J Med Screen. 2000;7(1):38-45. DOI: 10.1136/jms.7.1.38.

Atkin WS, Hart A, Edwards R, Cook C, Wardle J, McIntyre P, Aubrey R, Baron C, Sutton S, Cuzick J, Senapati A, Northover JMA. Single blind, randomised trial of efficacy and acceptability of oral picolax versus self-administered phosphate enema in bowel preparation for flexible sigmoidoscopy screening. BMJ. 2000 Jun 3;320(7248):1504-8. DOI: 10.1136/bmj.320.7248.1504.

1999

Bell GD, Atkin WS, Painter J, Rowland RS, Dogramadzi S. Increasing the reach of flexible sigmoidoscopy. Endoscopy. 1999 Nov;31(9):835-6.

Frew E, Wolstenholme JL, Atkin WS, Whynes DK. Estimating time and travel costs incurred in clinic-based screening: flexible sigmoidoscopy screening for colorectal cancer. J Med Screen. 1999;6(3):119-23. DOI: 10.1136/jms.6.3.119.

Wardle J, Taylor T, Sutton S, Atkin WS. Does publicity about cancer screening raise fear of cancer? Randomised trial of the psychological effect of information about cancer screening. BMJ. 1999 Oct 16;319(7216):1037-8. DOI : 10.1136/bmj.319.7216.1037.

1998

Hart AR, Kudo S, Mackay EH, Mayberry JF, Atkin WS. Flat adenomas exist in asymptomatic people: important implications for colorectal cancer screening programmes. Gut. 1998 Aug;43(2):229-31. DOI: 10.1136/gut.43.2.229.

Atkin WS, Hart A, Edwards R, McIntyre P, Aubrey R, Wardle J, Sutton S, Cuzick J, Northover JMA. Uptake, yield of neoplasia and adverse effects of flexible sigmoidoscopy. Gut. 1998 Apr;42(4):560-5. DOI: 10.1136/gut.42.4.560.

Atkin W. Flexible sigmoidoscopy as a mass screening tool. Eur J Gastroenterol Hepatol. 1998 Mar;10(3):219-23. DOI: 10.1097/00042737-199803000-00005.

1991 - 1996

Senore C, Segnan N, Rossini FP, Ferraris R, Cavallero M, Coppola F, Pennazio F, Atkin WS. Screening for colorectal cancer by once-only sigmoidoscopy: a feasibility study in Turin, Italy. J Med Screen. 1996;3(2):72-8. DOI: 10.1177/096914139600300205.

Saunders BP, Elsby B, Boswell AM, Atkin WS, Williams CB. Intravenous anti-spasmodic and patient-controlled analgesia are of benefit for screening flexible sigmoidoscopy. Gastrointest Endosc. 1995 Aug;42(2):123-7. DOI: 10.1016/s0016-5107(95)70067-6.

Atkin WS, Cuzick J, Northover JMA, Whynes DK. Prevention of colorectal cancer by ‘once-only’ sigmoidoscopy. Lancet. 1993 Mar 20;341(8847):736-40. DOI: 10.1016/0140-6736(93)90499-7.

Atkin WS, Morson BC, Cuzick JC. Long-term risk of colorectal cancer after excision of rectosigmoid adenomas. N Engl J Med. 1992 Mar 5;326(10):658-62. DOI: 10.1056/NEJM199203053261002.

Williams CB, Talbot IC, Atkin WS. Adenoma screening and colorectal cancer. BMJ. 1991 Oct 12;303(6807):925. DOI: 10.1136/bmj.303.6807.925.