The regulation of gene expression at the mRNA level allows eukaryotic cells to differentiate and adapt and is essential to the development of complex organisms.
FUSE Binding Proteins (FBPs) are a family of nucleic acid binding proteins that regulate gene expression at multiple levels. For example FBPs regulate both the synthesis and stability of the c-myc mRNA as well as the biogenesis of miRNA effectors.
This talk will describe the molecular interplay between the three members of the FBP family and their protein and nucleic acid partners and will present rules of recognition and mechanistic models of regulation