Further information
Professor Mark Smakes, School of Biosciences, University of Kent, presents this lecture on: “Manipulation of cellular processes and machinery for enhanced recombinant protein production in animal cells. “
Chair: Dr Karen Polizzi
Abstract: Recombinant protein yields from mammalian expression systems have increased dramatically over the last 20 years. The majority of these improvements have arisen from trial and error approaches with few developments to date directly from cell engineering strategies and as a result many have recently questioned the value of investigating such approaches. However, furthering our understanding of the molecular constraints upon recombinant protein expression in mammalian cells is not only useful in terms of identifying potential engineering targets, but also for the modelling and manipulation of cellular processes and to aid in the development of new screening methods for identifying better performing cells. Here recent work from our laboratory on (1) identifying and modelling the cellular constraints upon recombinant protein expression from mammalian cells and (2) the manipulation of cells and mRNA translation for enhanced yields from these systems will be discussed.
If you are interested in having a brief meeting to discuss research with Professor Smales on the day of the seminar, please contact Karen Polizzi; k.polizzi@imperial.ac.uk