Dr Brahim Benyahia, Loughborough University

A PSE roadmap for the design optimisation and control of the next generation single and integrated continuous pharmaceutical processes




The Covid-19 pandemic constitutes an unprecedented challenge to the global health systems, the pharmaceutical industry and all human activities, causing severe socioeconomic consequences. The most critical and visible impact on the pharmaceutical industry is undoubtably associated with the multiple shortages of pharmaceuticals due to a dramatic surge in demand but also to production and supply chain disruptions and bottlenecks. The outbreak put the pharmaceutical organisational and production paradigms under extreme pressure highlighting many glaring weaknesses. Despite the recent approval of several Covid 19 vaccines, there is an urgent need to adopt more flexible and effective R&D and manufacturing methods and reduce reliance on the traditionally batch processing. In this seminar, I will show how the Covid-19 pandemic has consolidated the strategic benefits of the integrated end-to-end continuous manufacturing, digitisation and PSE and I will highlight some opportunities that will shape the future of pharma and pave the way for the next generation flexible and sustainable continuous pharmaceutical plants. I will also share some of our recent applications of PSE tools, such as high-fidelity models, model-based DoE, optimisation and control alongside artificial intelligence, life cycle assessment (LCA) and multicriteria decision aiding, in crystallisation and integrated end-to-end continuous pharmaceutical manufacturing. The seminar will also discuss ways to address current and future skill gaps using Virtual and Augmented Reality.


Dr Brahim Benyahia graduated with an MEng (“Diplôme d’Ingénieur”) in Chemical Engineering from the National Polytechnic School, Algeria. He completed a PhD in Chemical Engineering, at the ENSIC (Engineering School of Chemical Industries) France, in December 2009, then moved for a postdoc associate position at Massachusetts Institute of Technology (MIT) USA, where he focused for 2.5 years on the development of the first end-to-end integrated continuous pharmaceutical manufacturing platform (a $65 M Novartis-MIT project). In 2013, Brahim joined Loughborough University as a lecturer in Chemical Engineering and was promoted to Senior Lecturer in 2017. In 2014, he was the co-recipient of the Council for Chemical Research (CCR) Collaboration Award and the recipient of Teaching Award of Chemical Engineering (2015, 2016, 2017 and 2018).


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When: 1st March 2021 13:00 PM London
Topic: Sargent Centre Seminar Series: Dr Brahim Benyahia (Loughborough University)

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