Solvent Mixtures Design and Optimisation of Purification Processes in Pharmaceutical Manufacturing
Solvent mixtures play an important role throughout the manufacturing of pharmaceutical and chemical products. Their extensive use across production processes (e.g. synthesis, separation and purification) has major impacts on overall process efficiency and final product quality, as well as making solvent selection a key concern from environmental and safety perspectives. In current industrial practice, several critical decisions involved in the design of a process or product, such as the choice of suitable ingredients (e.g., solvents) and process conditions, rely on either heuristic approaches or time-consuming experimental studies. Such trail-and-error practices can often be expensive and are liable to lead to sub-optimal designs that fail to consider the integrated nature of all design decisions. Thus, the development of fast and efficient methodologies to explore all possible options would be an indispensable tool in the design of improved pharmaceutical processes and better chemical products. In this talk, I will present recent advances in systematic methodologies for the design of solvent mixtures used in the purification of pharmaceutical compounds and the design of chemical product formulations. Within the proposed approach, state-of-the-art thermodynamic models are used to integrate property prediction with process modelling, while advanced optimisation techniques are employed to search the vast design space of potential solvents and process conditions and suggest the most promising design options. The methodology is applied to the design of solvent mixtures for the integrated crystallization and isolation of active pharmaceutical ingredients and the design of optimal environmentally friendly adhesive products. This work shows that a comprehensive approach where the optimal chemicals, mixture compositions, and process conditions are identified simultaneously, can lead to improved process efficiency and product performance over conventional designs.
Dr. Suela Jonuzaj completed her PhD in the area of molecular and mixture design in the Centre for Process Systems Engineering at Imperial College London. In September 2017, she secured an EPSRC Doctoral Prize Fellowship, which provided her with a year of post-doctoral funding; and in October 2018, she joined the CMAC Future Manufacturing Research Hub, where she works on solvent mixture design for the integrated purification processes of pharmaceuticals.
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When: 2nd September, 2020 13:00 PM London
Topic: CPSE Summer Webinar Series: Dr Suela Jonuzaj (CPSE, Imperial College London)
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The Centre for Process Systems Engineering (CPSE) is a multi- institutional research centre. It was inaugurated in August 1989 by Professor Roger W.H. Sargent and involves Imperial College London and University College London. Innovative and dynamic in its approach to research and development, CPSE’s accomplishments include the Queens Prize for Higher Education, presented in 2003 for research excellence and technology transfer. Three spin-out companies have been established. One of these, Process Systems Enterprise Limited (PSE), received the Royal Academy of Engineering’s MacRobert Award in 2007; this is the UK’s highest award for innovation in engineering. The Centre continues to broaden the scope of its activities over all size scales enabling all areas of process systems to be addressed. This enables CPSE to be responsive to the evolving needs of industry and society.