Join us for the Autumn Series

of the Wright Fleming Institute (hybrid) Seminars

Dr Leo Swadling

Biography

Dr Leo Swadling is a new group leader and Advancement Fellow (Rosetrees Trust/Pears Foundation) in the Infection and Immunity division at UCL. He obtained his PhD from the University of Oxford, developing genetic and molecular technologies to optimise vaccines for viral hepatitis with Profs Ellie Barnes and Paul Klenerman. He moved to London to study liver-resident T cells with Professor Mala Maini and during the pandemic has switched his focus to characterising T cell responses to SARS-CoV-2 as part of the UK-Coronavirus immunology consortium (https://www.uk-cic.org/) and COVIDsortium (https://covid-consortium.com/). 

Overall their research aims to establish T cell correlates of protection by integrating high-resolution single-cell studies of T cell quality (function, phenotype, trafficking) and specificity (virus, protein, epitope, TCR clonality) at the extremes of controlled or uncontrolled viral infections, and to design vaccines to recapitulate and test these correlates. 

The talk will focus on their work contrasting T cell specificity in the context of abortive and laboratory confirmed SARS-CoV-2 infection in a prospective health care worker study, in particular the influence of pre-existing T cells targeting the highly conserved replication-transcription complex on outcome to viral exposure. Further info: https://twitter.com/Leo1401j   https://www.researchgate.net/profile/Leo-Swadling

Join in person at the St Mary’s Campus, Medical School Building, Roger Bannister Lecture Theatre, 1st Floor or
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Meeting ID: 356 829 473 417
Passcode: 7B9JVB