The Cancer Research UK Convergence Science Centre brings you:
Converging on cancer – engineering and physical sciences and multidisciplinary approaches to advance cancer research seminar series
16th March 15.00 – 16.00
Please join us for an online seminar on Thursday 16th March, from 15.00-16.00 where you will hear a talk from:
Chirine Sakr and Annie Baker – Genomics and Evolutionary Dynamics Team, Institute of Cancer Research, London
“Understanding tumour-immune co-evolution using highly multiplexed imaging”
Highly multiplexed imaging facilitates the parallel characterisation of immune and stromal cell populations together with the local tumour cell phenotype. In contrast to single cell sequencing (which is typically destructive of the tissue architecture), imaging-based approaches retain the native spatial structure and histopathological context. This allows for the quantification of epithelial-immune interactions and cellular neighbourhoods, and inference of which environments are promoting or constraining tumour progression.
In this talk, we will describe the generation and analysis of highly multiplexed imaging datasets in our lab. We will highlight how these data can provide new insight into tumour biology and evolution. Finally, we will introduce the Akoya Phenocycler and comment on how teams within the Convergence Science Centre can access this technology.
Dr Annie Baker is a Staff Scientist working in the Genomics and Evolutionary Dynamics Team at the Institute of Cancer Research (ICR). Annie received her undergraduate degree in Biochemistry from the University of Oxford, and her PhD from the ICR. She was a Postdoc and then a Senior Scientific Officer at Barts Cancer Institute, before moving back to the ICR in early 2022 with Prof Trevor Graham. Her research combines genomics, histology and molecular biology to understand the co-evolution of tumour cells and their microenvironment.
Chirine Sakr is a Higher Scientific Officer working in the Genomics and Evolutionary Dynamics Team at the ICR, and she is funded by the Convergence Science Centre. Chirine received her undergraduate degree in Biomedical Sciences from the University of Portsmouth, and her masters’s degree from the University of Nottingham. She is an expert in generating multiplexed imaging data, and currently runs the Akoya Phenocycler-Fusion based in the Centre for Evolution and Cancer at the ICR.
Registration
To receive information about how to access this event please email icr-imperial-convergence.centre@imperial.ac.uk
Please note: This webinar is exclusively available only to colleagues across the Institute of Cancer Research, Imperial College London, the Royal Marsden Hospital and Imperial College Healthcare.