The next talk in the Inflammation Repair and Development seminar series will be given by Dr. Roberto Tinoco, Assistant Professor at University of California, Irvine. Dr. Tinoco is interested in immune responses to respiratory viruses and discovered an important function for fucosyltransferases in supporting memory CD4+ T cell differentiation during influenza viral infection (J Immunology 2018). His laboratory continues efforts to uncover immune regulators that promote T cell dysfunction during viral infections and tumors. He is also collaborating with CVR members to investigate immune responses to the novel coronavirus, SARS-CoV-2.
Dr. Tinoco completed his Ph.D. training at UC San Diego, and discovered how transforming growth factor beta (TGF-b) signaling promoted the generation of exhausted T cell during chronic viral infection (Immunity 2009). As a postdoctoral fellow at SBP Discovery and UC San Diego, he discovered a new immune checkpoint function for the adhesion molecule, P-selectin glycoprotein ligand-1 (PSGL-1) that induced T cell exhaustion during chronic viral infection and melanoma tumor development (Immunity 2016).
The title of his presentation will be ‘HMGB2 Regulates the Differentiation and Stemness of Exhausted CD8+ T Cells During Chronic Viral Infection and Cancer‘.
Please contact r.joulia@imperial.ac.uk or g.moss@imperial.ac.uk for further information.