Summary of talk
Steroid Hormone Receptors are critical drivers in the development of multiple cancer types, including breast cancer and prostate cancer. They serve as hormone-driven transcription factors, regulating genetic programs to ultimately dictate tumor progression. Consequently, therapeutics inhibiting their action, represent the most-successful and earliest targeted therapeutic strategies in cancer. However, resistance to treatment is common, ultimately resulting in therapy resistant disease that cannot be cured. By monitoring biological changing in response to therapy exposure and hormonal stimuli, biomarkers and drivers of therapy resistance can be revealed. These studies are designed to better understand the fundamental basis of hormone receptor biology -monitoring the formation the transcription complex in time- of but also the plasticity thereof -on single cell level in space- forming the very basis of therapy resistance.