On Friday, 19th September 2025, we will be welcoming Professor Tzung Hsiai, Professor of Cardiovascular Medicine & Bioengineering, UCLA, to the Vascular Science Seminar Series.
Details as follows:
Date: Monday, 19th Sept 2025
Time: 13:30 to 14:30 UK time
Talk title: Mechanotransduction and Light-Sheet Imaging to Reveal a Continuum of Molecular Transducers for Vascular Resilience
Hosted by Dr Daniela Pirri
Location: Rooms 527/528, 5th Floor ICTEM Building, Hammersmith Campus
Talk Summary: During cardiovascular development, peristaltic contraction of the embryonic heart tube produces time-varying hemodynamic forces and pressure gradients across the atrioventricular canal. However, the relative importance of myocardial contraction and hemodynamic forces in modulating cardiovascular morphogenesis in the non-Newtonian flow regime remains poorly understood. Using our custom-built 4-D light-sheet fluorescent microscope and post-imaging machine-learning algorithms, we recapitulate flow-mediated molecular transducers underlying vascular injury and regeneration in the zebrafish vascular injury model. We further elucidate habitual exercise-mediated metabolomic interactions underlying the activation of endothelial molecular transducers to catalyze anti-inflammatory metabolites. In this context, we integrate multi-scale mechano-transcriptomic interaction from zebrafish to pre-clinical models and demonstrate flow-responsive therapeutic targets for cardiovascular development, repair, and resilience.
Please note this is an in-person only event – click here to register.
VS Seminars Team