Symposium Purpose
This virtual symposium brings together principal investigators from landmark randomised controlled trials (RCTs) of hypothermic neuroprotection – trials that have shaped current clinical practice – along with international experts in neonatal neurology, imaging, and neurophysiology to review two decades of evidence on therapeutic hypothermia for hypoxic–ischaemic encephalopathy (HIE) and future directions.
It will highlight the vital role of high-quality RCTs in guiding clinical practice, preventing patient harm, and the substantial international effort required to deliver time-critical neuroprotection trials. An essential symposium for all clinicians and researchers caring for infants with HIE.
Download the full programme (PDF)
Event Agenda
Day 1 | What we know so far
| Time | Session | Speaker |
| 13:00 – 13:00 | Welcome | Prof. Shankaran & Dr. Garegrat |
| 13:05 – 13:45 | Original Hypothermia and Optimising Cooling Trials | Prof. Shankaran |
| 13:45 – 14:25 | Delayed Hypothermia Trial | Prof. Laptook |
| 14:25 – 15:05 | Hypothermia in LMIC (HELIX Trial) |
Prof. Thayyil |
| 15:05 – 15:15 | Short Break |
– |
| 15:15 – 15:55 |
Premature Infant Hypothermia Trial | Prof. Faix |
| 15:55 – 16:35 | Telemedicine in the Assessment of HIE |
Dr. Craig |
| 16:35 – 17:15 |
Explaining Outcomes After HIE to Parents | Dr. Lemmon |
| 17:15 – 17:30 | Panel Discussion & Wrap-Up |
– |
Day 2 | What we need to know
| Time | Session | Speaker |
| 13:00 – 13:05 | Welcome | Prof. Shankaran & Dr. Garegrat |
| 13:05 – 13:45 | MR Imaging in HIE | Prof. Grant |
| 13:45 – 14:25 | Seizures in HIE | Dr. Pressler |
| 14:25 – 15:05 | Outcomes After Mild HIE | Prof. Murray |
| 15:05 – 15:15 | Short Break | – |
| 15:15 – 15:55 | Outcomes After Birth Acidosis Without Mild HIE | Prof. Sabir |
| 15:55 – 16:35 | COOL PRIME Study | Dr. Chalak |
| 16:35 – 17:15 |
COMET Trial | Prof. Thayyil |
| 17:15 – 17:30 | Panel Discussion & Wrap-Up | – |