In this talk, Professor Frank Harrell will discuss several ways to make clinical trials more efficient and to reduce the chance of ending with an equivocal result. Some of the approaches covered are Bayesian sequential designs allowing for study extension if results are promising, not being tied by type I assertion probabilities/α spending, using high-information longitudinal ordinal outcomes, and covariate adjustment.
Speaker Bio
Frank Harrell is a Professor of Biostatistics at Vanderbilt University School of Medicine. He is an Associate Director of the VICTR Research Methods Program. He is a Co-Director, Study Design Core, Trial Innovation Center. Professor Harrell gained his PhD in Biostatistics from the University of North Carolina. His Research interests include: development of accurate prognostic and diagnostic models, model validation, clinical trials, observational clinical research, cardiovascular research, technology evaluation, pharmaceutical safety, Bayesian methods, quantifying predictive accuracy, missing data imputation, statistical graphics and reporting.
Lunch/nibbles will be served afterwards.
Hosted by the National Heart and Lung Institute and NIHR Imperial Biomedical Research Centre