12:00         Dr Tom Hooper: Palladium catalysed C-H bond alumination

12:20        Dr Daniel Scott: Establishing ‘ROH’ tolerance in FLP chemistry:   Moisture tolerance and carbonyl reduction in TM-free hydrogenation catalysis

12:40         Professor Mike Hill, University of Bath: Nucleophilic boron: the easy way

Nucleophilic boron: the easy way

Prof. Michael S. Hill

Department of Chemistry, University of Bath, Claverton Down, Bath, BA2 7AY, UK

Abstract:

Organomagnesium (Grignard) reagents have been one of the workhorses of organic synthesis, allowing the nucleophilic alkylation of a wide range of electrophilic reaction partners, for over 100 years. This talk will describe our recent efforts to develop straightforward routes to magnesium boryls (e.g. 1) which enable the direct nucleophilic borylation of electrophiles.1 These compounds are easily generated and can provide a straightforward means to generate C-B and B-B bonds, both of which will be described in the talk.

(1)

1 Pécharman, A. F., Colebatch, A. L., Hill, M. S., McMullin, C. L., Mahon, M. F. and Weetman, C.,

Nature Communications, 8, 15022 (2017).