Abstract: The Riemann hypothesis asserts that the nontrivial zeros of the Riemann zeta function should be of the form 1/2 + i E_n, where the set of numbers {E_n} are real. The so-called Hilbert-Pólya conjecture assumes that {E_n} should correspond to the eigenvalues of an operator that is Hermitian. The discovery of such an operator, if it exists, thus amounts to providing a proof of the Riemann hypothesis. In 1999 Berry and Keating conjectured that such an operator should correspond to a quantisation of the classical Hamiltonian H = xp. Since then, the Berry-Keating conjecture has been investigated intensely in the literature, but its validity has remained elusive up to now. In this talk I will derive a “Hamiltonian” (a differential operator), whose classical counterpart is H = xp, having the property that with a suitable boundary condition on its eigenstates, the eigenvalues {E_n} correspond to the nontrivial zeros of the Riemann zeta function, thus confirming the Berry-Keating conjecture. However, an independent proof of the reality of the eigenvalues appears difficult, casting doubts on the viability of the spectral approach to the Riemann hypothesis. The talk is based in part on the work carried out in collaboration with Carl M. Bender (Washington University) and Markus P. Müller (University of Western Ontario).