In this section
@article{Cookson:2002:10.1016/S0889-8561(01)00005-4,
author = {Cookson, WOCM and Harper, JI and Moffatt, MF},
doi = {10.1016/S0889-8561(01)00005-4},
journal = {Immunology and Allergy Clinics of North America},
pages = {199--209},
title = {Genetics of atopic dermatitis},
url = {http://dx.doi.org/10.1016/S0889-8561(01)00005-4},
volume = {22},
year = {2002}
}
TY - JOUR
AB - Even though the comprehension of the genetics of AD is at an early stage, further studies offer the promise of a greater understanding. The preliminary findings emphasize the importance of the skin as a barrier and suggest that the atopy that accompanies AD might be as much a secondary phenomenon as a primary phenomenon. The barrier function of the skin is not merely passive, and the skin maintains a specific immunologic environment, referred to as the skin immune system [76]. The skin immune system is characterized by the presence of a dense network of dendritic, antigen-presenting cells (Langerhan's cells) in the epidermis and perivascular localization of T lymphocytes that are activated even in the skin of normal individuals [76,77]. The polymorphic nature of genes and gene families expressed in the skin suggest a polyvalent response to a number of different stimuli, including infections. It is possible that some of these proteins might have unrecognized anti-infective properties. The recognition of the importance of genetic effects to AD, together with advances in the understanding and technology of complex genetics, will result in a new understanding of AD.
AU - Cookson,WOCM
AU - Harper,JI
AU - Moffatt,MF
DO - 10.1016/S0889-8561(01)00005-4
EP - 209
PY - 2002///
SN - 0889-8561
SP - 199
TI - Genetics of atopic dermatitis
T2 - Immunology and Allergy Clinics of North America
UR - http://dx.doi.org/10.1016/S0889-8561(01)00005-4
VL - 22
ER -
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