In this section
@article{Dekker:1997,
author = {Dekker, JW and Nizankowska, E and Schmitz-Schumann, M and Pile, K and Bochenek, G and Dyczek, A and Cookson, WO and Szczeklik, A},
journal = {Clin Exp Allergy},
pages = {574--577},
title = {Aspirin-induced asthma and HLA-DRB1 and HLA-DPB1 genotypes.},
url = {https://www.ncbi.nlm.nih.gov/pubmed/9179433},
volume = {27},
year = {1997}
}
TY - JOUR
AB - BACKGROUND: Aspirin-induced asthma (AIA) affects one in 10 individuals with adult-onset asthma. It is not known if aspirin sensitivity is due to immune mechanisms or to interference with biochemical pathways. OBJECTIVE: The study aimed to test for possible involvement of the genes of the Major Histocompatibility Complex (MHC) in AIA. METHODS: HLA-DPB1 and HLA-DRB1 genotyping was carried out by DNA methods in 59 patients with positive challenge tests for AIA and in 48 normal and 57 asthmatic controls. RESULTS: The DPB10301 frequency was increased in AIA patients when compared with normal controls (19.5% vs 5.2%, Odds Ratio = 4.4, 95% Confidence Interval (CI) 1.6-12.1, P = 0.002), and compared with asthmatic controls (4.4%, OR = 5.3, 95% CI = 1.9-14.4, P = 0.0001). The frequency of DPB10401 in AIA subjects was decreased when compared with normal controls (28.8% vs 49.0%, OR = 0.42, 95% CI = 0.24-0.74, P = 0.003) and asthmatic controls (45.6%, OR = 0.48, 95% CI = 0.28-0.83, P = 0.008). The results remained significant when corrected for multiple comparisons. There were no significant HLA-DRB1 associations with AIA. CONCLUSION: The presence of an HLA association suggests that immune recognition of an unknown antigen may be part of the aetiology of AIA.
AU - Dekker,JW
AU - Nizankowska,E
AU - Schmitz-Schumann,M
AU - Pile,K
AU - Bochenek,G
AU - Dyczek,A
AU - Cookson,WO
AU - Szczeklik,A
EP - 577
PY - 1997///
SN - 0954-7894
SP - 574
TI - Aspirin-induced asthma and HLA-DRB1 and HLA-DPB1 genotypes.
T2 - Clin Exp Allergy
UR - https://www.ncbi.nlm.nih.gov/pubmed/9179433
VL - 27
ER -
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