BibTex format
@article{Organ:2019:10.1186/s12931-019-1118-7,
author = {Organ, L and Duggan, A-M and Oballa, E and Taggart, S and Simpson, J and Kangombe, A and Braybrooke, R and Molyneaux, P and North, B and Karkera, Y and Leeming, D and Karsdal, M and Nanthakumar, C and Fahy, W and Marshall, R and Jenkins, G and Maher, T},
doi = {10.1186/s12931-019-1118-7},
journal = {Respiratory Research},
pages = {1--10},
title = {Biomarkers of collagen synthesis predict progression in the PROFILE idiopathic pulmonary fibrosis cohort.},
url = {http://dx.doi.org/10.1186/s12931-019-1118-7},
volume = {20},
year = {2019}
}
RIS format (EndNote, RefMan)
TY - JOUR
AB - Idiopathic pulmonary fibrosis (IPF) is characterised by excessive extracellular matrix (ECM) deposition and remodelling. Measuring this activity provides an opportunity to develop tools capable of identifying individuals at-risk of progression. Longitudinal change in markers of ECM synthesis was assessed in 145 newly-diagnosed individuals with IPF.Serum levels of collagen synthesis neoepitopes, PRO-C3 and PRO-C6 (collagen type 3 and 6), were elevated in IPF compared with controls at baseline, and progressive disease versus stable disease during follow up, (PRO-C3 p < 0.001; PRO-C6 p = 0.029). Assessment of rate of change in neoepitope levels from baseline to 3 months (defined as ‘slope to month 3’: HIGH slope, slope > 0 vs. LOW slope, slope < =0) demonstrated no relationship with mortality for these markers (PRO-C3 (HR 1.62, p = 0.080); PINP (HR 0.76, p = 0.309); PRO-C6 (HR 1.14, p = 0.628)). As previously reported, rising concentrations of collagen degradation markers C1M, C3M, C6M and CRPM were associated with an increased risk of overall mortality (HR = 1.84, CI 1.03–3.27, p = 0.038, HR = 2.44, CI 1.39–4.31, p = 0.002; HR = 2.19, CI 1.25–3.82, p = 0.006; HR = 2.13 CI 1.21–3.75, p = 0.009 respectively).Elevated levels of PRO-C3 and PRO-C6 associate with IPF disease progression. Collagen synthesis and degradation biomarkers have the potential to enhance clinical trials in IPF and may inform prognostic assessment and therapeutic decision making in the clinic.
AU - Organ,L
AU - Duggan,A-M
AU - Oballa,E
AU - Taggart,S
AU - Simpson,J
AU - Kangombe,A
AU - Braybrooke,R
AU - Molyneaux,P
AU - North,B
AU - Karkera,Y
AU - Leeming,D
AU - Karsdal,M
AU - Nanthakumar,C
AU - Fahy,W
AU - Marshall,R
AU - Jenkins,G
AU - Maher,T
DO - 10.1186/s12931-019-1118-7
EP - 10
PY - 2019///
SN - 1465-9921
SP - 1
TI - Biomarkers of collagen synthesis predict progression in the PROFILE idiopathic pulmonary fibrosis cohort.
T2 - Respiratory Research
UR - http://dx.doi.org/10.1186/s12931-019-1118-7
UR - https://respiratory-research.biomedcentral.com/articles/10.1186/s12931-019-1118-7
VL - 20
ER -