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• Journal article
  Freidin MB, Bhudia N, Lim E, Nicholson AG, Cookson WO, Moffatt MFet al., 2012,

  Impact of Collection and Storage of Lung Tumor Tissue on Whole Genome Expression Profiling

  , JOURNAL OF MOLECULAR DIAGNOSTICS, Vol: 14, Pages: 140-148, ISSN: 1525-1578
  • Cite
  • Citations: 38
• Journal article
  Corte TJ, Copley SJ, Desai SR, Zappala CJ, Hansell DM, Nicholson AG, Colby TV, Renzoni E, Maher TM, Wells AUet al., 2012,

  Significance of connective tissue disease features in idiopathic interstitial pneumonia

  , EUROPEAN RESPIRATORY JOURNAL, Vol: 39, Pages: 661-668, ISSN: 0903-1936
  • Author Web Link
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  • Citations: 148
• Journal article
  Bai C, Liu X, Fisher MC, Garner TWJ, Li Yet al., 2012,

  Global and endemic Asian lineages of the emerging pathogenic fungus Batrachochytrium dendrobatidis widely infect amphibians in China

  , DIVERSITY AND DISTRIBUTIONS, Vol: 18, Pages: 307-318, ISSN: 1366-9516
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  • Citations: 74
• Journal article
  Ito K, Arko M, Kawaguchi T, Kikusui T, Kuwahara M, Tsubone Het al., 2012,

  Intracerebroventricular administration of taurine impairs learning and memory in rats.

  , Nutr Neurosci, Vol: 15, Pages: 70-77

  OBJECTIVES: Taurine is a semi-essential amino acid widely distributed in the body and we take in it from a wide range of nutritive-tonic drinks to improve health. To date, we have elucidated that oral supplementation of taurine does not affect learning and memory in the rat. However, there are few studies concerning the direct effects of taurine in the brain at the behavior level. In this study, we intracerebroventricularly administered taurine to rats and aimed to elucidate the acute effects on learning and memory using the Morris water maze method. METHODS: Escape latency, swim distance, and distance to zone, which is the integral of the distance between the rats and the platform for every 0.16 seconds, were adopted as parameters of the ability of learning and memory. We also tried to evaluate the effect of intraperitoneal taurine administration. RESULTS: Escape latency, swim distance, and distance to zone were significantly longer in the intracerebroventricularly taurine-administered rats than in the saline-administered rats. Mean swimming velocity was comparable between these two groups, although the physical performance was improved by taurine administration. Probe trials showed that the manner of the rats in finding the platform was comparable. In contrast, no significant differences were found between the intraperitoneally taurine-administered rats and the saline-administered rats. DISCUSSION: These results indicate that taurine administered directly into the brain ventricle suppresses and delays the ability of learning and memory in rats. In contrast, it is implied that taurine administered peripherally was not involved in learning and memory.

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• Journal article
  Logez C, Alkhalfioui F, Byrne B, Wagner Ret al., 2012,

  Preparation of Pichia pastoris expression plasmids

  , Methods in Molecular Biology, Vol: 866, Pages: 25-40
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• Journal article
  McMahon MA, Chotirmall SH, McCullagh B, Branagan P, McElvaney NG, Logan PMet al., 2012,

  Radiological abnormalities associated with <i>Aspergillus</i> colonization in a cystic fibrosis population

  , EUROPEAN JOURNAL OF RADIOLOGY, Vol: 81, Pages: E197-E202, ISSN: 0720-048X
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• Journal article
  Shirshova N, Bismarck A, 2012,

  In-situ preparation of polymer scaffolds in retarded cement slurries: An emulsion templating approach for rapid, on-demand strength development

  , CEMENT & CONCRETE COMPOSITES, Vol: 34, Pages: 337-341, ISSN: 0958-9465
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  • Citations: 6
• Journal article
  Glassford S, Chan KLA, Byrne B, Kazarian SGet al., 2012,

  Chemical Imaging of Protein Adsorption and Crystallization on a Wettability Gradient Surface

  , LANGMUIR, Vol: 28, Pages: 3174-3179, ISSN: 0743-7463
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  • Citations: 32
• Conference paper
  Sarnowski C, Malerba G, Laprise C, Rohde K, Moffatt M, Jeannin P, Dizier M-H, Pignatti PF, Cookson WOC, Lathrop M, Demenais F, Bouzigon Eet al., 2012,

  Taking Into Account Imprinting And Maternal Genotype Effects Facilitates Detection Of New Genes

  , 20th Annual Meeting of the International-Genetic-Epidemiology-Society (IGES), Publisher: WILEY-BLACKWELL, Pages: 122-123, ISSN: 0741-0395
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• Journal article
  Singh S, Zhang M, Bertheleme N, Kara E, Strange PG, Byrne Bet al., 2012,

  Radioligand binding analysis as a tool for quality control of GPCR production for structural characterization: adenosine A(2a)R as a template for study.

  , Curr Protoc Protein Sci, Vol: Chapter 29, Pages: 29.3.1-29.3.22

  Functional characterization of G protein-coupled receptors is essential to ascertain the suitability of a protein target for downstream studies and to help develop optimal expression and isolation procedures. Radioligand binding analysis is a well-established technique, which allows direct measurement of the amount of functional receptor in a sample. It can be readily applied to both membrane-bound and soluble receptor samples and is an ideal method for monitoring the amount of functional protein at each stage in the expression and isolation process. This unit presents protocols for the radioligand binding analysis of the human adenosine A(2a) receptor and provides examples of how these assays can be used at several stages to help optimize expression, solubilization, and isolation procedures.

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