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  • Journal article
    Durham SR, Keenan J, Cookson WO, Craddock CF, Benson MKet al., 1989,

    Diurnal variation in serum cortisol concentrations in asthmatic subjects after allergen inhalation.

    , Thorax, Vol: 44, Pages: 582-585, ISSN: 0040-6376

    To assess whether differences in the adrenal response to allergen are important in determining the magnitude of the allergen induced late responses in asthmatic subjects, we measured serum cortisol concentrations after inhalation challenge with allergen or control solution (phosphate buffered saline). The two challenges were performed in random order with an interval of 14 days. A normal diurnal decrease in serum cortisol concentrations was observed on both days. Mean blood cortisol concentrations three hours after inhalation of allergen (before the late response), nine hours afterwards (at the time of the late response), and 24 hours afterwards were virtually identical to those observed after inhalation of phosphate buffered saline. Serum cortisol concentrations before challenge and three, nine, and 24 hours after challenge were not related to the diurnal increase in blood eosinophils on the control day, or to the size of the late asthmatic response or accompanying changes in blood eosinophils after allergen challenge. It is concluded that serum cortisol concentrations show normal diurnal variation after allergen challenge and are unrelated to the size of the late response or associated changes in blood eosinophil counts.

  • Journal article
    de Klerk NH, Cookson WO, Musk AW, Armstrong BK, Glancy JJet al., 1989,

    Natural history of pleural thickening after exposure to crocidolite.

    , Br J Ind Med, Vol: 46, Pages: 461-467, ISSN: 0007-1072

    Serial plain chest radiographs of 384 men who worked at the Wittenoom crocidolite mine and mill between 1943 and 1966 and who applied for pneumoconiosis compensation between 1948 and 1982 have been examined independently by two trained observers for pleural disease using the 1980 ILO-UICC classification of radiographs to record width and extent of pleural disease. Radiographs covering follow up periods of from two to 38 years were examined (median number of films per subject was nine). The degree of crocidolite exposure was estimated from employment records and a survey of airborne fibre concentrations performed in 1966. Agreement between the observers on the presence and degree of pleural disease in the final film for each subject was moderately close (Kendall's tau B = 0.62) and was least for subjects with thickening less than 5 mm in width. Diffuse pleural thickening extending for greater than 50% of the lateral chest wall was the most common type recorded by both observers. Minor pleural thickening frequently progressed in extent along the lateral chest wall but progression beyond 5 mm in thickness was less common. Pleural plaques were not seen to progress beyond their initial thickness or extent. The rate of onset of thickening in this population increased continually from the time of first exposure and also increased slightly with age. There was evidence that the level of total cumulative exposure to crocidolite increased the rate of onset of pleural thickening in the period between five and 15 years after first exposure. Rate of progression of established thickening was greatest in subjects who first developed thickening early after first exposure. The relative rate of progression decreased slowly with time from first signs of thickening and there was no evidence of any progression more than 15 years after onset.

  • Journal article
    Cookson WO, Sharp PA, Faux JA, Hopkin JMet al., 1989,

    Linkage between immunoglobulin E responses underlying asthma and rhinitis and chromosome 11q.

    , Lancet, Vol: 1, Pages: 1292-1295, ISSN: 0140-6736

    Family studies of IgE responses to common inhaled antigens have suggested dominant inheritance of atopy. Molecular genetic linkage analysis was used to confirm this proposal. In seven families the transmission of atopy was linked, with a maximum lod score of 5.58, to a DNA polymorphism defined by p lambda MS.51, which confirms dominant inheritance and assigns the gene locus to chromosome 11.

  • Journal article
    CODIGNOLA A, VEROTTA L, SPANU P, MAFFEI M, SCANNERINI S, BONFANTEFASOLO Pet al., 1989,

    CELL-WALL BOUND-PHENOLS IN ROOTS OF VESICULAR-ARBUSCULAR MYCORRHIZAL PLANTS

    , NEW PHYTOLOGIST, Vol: 112, Pages: 221-228, ISSN: 0028-646X
  • Journal article
    SPANU P, BOLLER T, LUDWIG A, WIEMKEN A, FACCIO A, BONFANTEFASOLO Pet al., 1989,

    CHITINASE IN ROOTS OF MYCORRHIZAL ALLIUM-PORRUM - REGULATION AND LOCALIZATION

    , PLANTA, Vol: 177, Pages: 447-455, ISSN: 0032-0935
  • Journal article
    HULL EP, GREEN PM, ARST HN, SCAZZOCCHIO Cet al., 1989,

    CLONING AND PHYSICAL CHARACTERIZATION OF THE L-PROLINE CATABOLISM GENE-CLUSTER OF ASPERGILLUS-NIDULANS

    , MOLECULAR MICROBIOLOGY, Vol: 3, Pages: 553-559, ISSN: 0950-382X
  • Journal article
    Cookson WO, Craddock CF, Benson MK, Durham SRet al., 1989,

    Falls in peripheral eosinophil counts parallel the late asthmatic response.

    , Am Rev Respir Dis, Vol: 139, Pages: 458-462, ISSN: 0003-0805

    Peripheral eosinophil counts were measured at intervals before and after control and allergen inhalation in 14 asthmatic subjects. A relative fall in eosinophil counts was noted 9 h after allergen challenge, in contrast to the diurnal increase seen on the control day (p = 0.005). This fall in eosinophil count correlated strongly with the magnitude of the late asthmatic response (r = -0.72, p = 0.003) and with the changes in bronchial responsiveness to histamine at 3 and 24 h after allergen was given (r = 0.54, p = 0.044 and r = 0.82, p less than 0.001, respectively). The findings demonstrate eosinophil kinetics are related to the occurrence of late-phase reactions and to the associated worsening of bronchial hyperreactivity.

  • Journal article
    De Klerk NH, Cookson WOC, Musk AW, Armstrong BK, Clancy JJet al., 1989,

    Natural history of pleural thickening after exposure to crocidolite

    The effect of exposure to crocidolite asbestos on pleural thickening is investigated.

  • Journal article
    ARST HN, TOLLERVEY D, CADDICK MX, 1989,

    A TRANSLOCATION ASSOCIATED, LOSS-OF-FUNCTION MUTATION IN THE NITROGEN METABOLITE REPRESSION REGULATORY GENE OF ASPERGILLUS-NIDULANS CAN REVERT INTRACISTRONICALLY

    , MOLECULAR & GENERAL GENETICS, Vol: 215, Pages: 364-367, ISSN: 0026-8925
  • Conference paper
    SPANU P, BOLLER T, 1989,

    ETHYLENE BIOSYNTHESIS IN TOMATO INFECTED BY PHYTOPHTHORA-INFESTANS

    , CONF ON BIOCHEMICAL AND PHYSIOLOGICAL ASPECTS OF ETHYLENE PRODUCTION IN LOWER AND HIGHER PLANTS, Publisher: KLUWER ACADEMIC PUBL, Pages: 255-260

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