BibTex format
@article{Li:2022:10.1016/j.chom.2022.08.005,
author = {Li, L and Mac, Aogáin M and Xu, T and Jaggi, TK and Chan, LLY and Qu, J and Wei, L and Liao, S and Cheng, HS and Keir, HR and Dicker, AJ and Tan, KS and De, Yun W and Koh, MS and Ong, TH and Lim, AYH and Abisheganaden, JA and Low, TB and Hassan, TM and Long, X and Wark, PAB and Oliver, B and Drautz-Moses, DI and Schuster, SC and Tan, NS and Fang, M and Chalmers, JD and Chotirmall, SH},
doi = {10.1016/j.chom.2022.08.005},
journal = {Cell Host Microbe},
pages = {1311--1327.e8},
title = {Neisseria species as pathobionts in bronchiectasis.},
url = {http://dx.doi.org/10.1016/j.chom.2022.08.005},
volume = {30},
year = {2022}
}
RIS format (EndNote, RefMan)
TY - JOUR
AB - Neisseria species are frequently identified in the bronchiectasis microbiome, but they are regarded as respiratory commensals. Using a combination of human cohorts, next-generation sequencing, systems biology, and animal models, we show that bronchiectasis bacteriomes defined by the presence of Neisseria spp. associate with poor clinical outcomes, including exacerbations. Neisseria subflava cultivated from bronchiectasis patients promotes the loss of epithelial integrity and inflammation in primary epithelial cells. In vivo animal models of Neisseria subflava infection and metabolipidome analysis highlight immunoinflammatory functional gene clusters and provide evidence for pulmonary inflammation. The murine metabolipidomic data were validated with human Neisseria-dominant bronchiectasis samples and compared with disease in which Pseudomonas-, an established bronchiectasis pathogen, is dominant. Metagenomic surveillance of Neisseria across various respiratory disorders reveals broader importance, and the assessment of the home environment in bronchiectasis implies potential environmental sources of exposure. Thus, we identify Neisseria species as pathobionts in bronchiectasis, allowing for improved risk stratification in this high-risk group.
AU - Li,L
AU - Mac,Aogáin M
AU - Xu,T
AU - Jaggi,TK
AU - Chan,LLY
AU - Qu,J
AU - Wei,L
AU - Liao,S
AU - Cheng,HS
AU - Keir,HR
AU - Dicker,AJ
AU - Tan,KS
AU - De,Yun W
AU - Koh,MS
AU - Ong,TH
AU - Lim,AYH
AU - Abisheganaden,JA
AU - Low,TB
AU - Hassan,TM
AU - Long,X
AU - Wark,PAB
AU - Oliver,B
AU - Drautz-Moses,DI
AU - Schuster,SC
AU - Tan,NS
AU - Fang,M
AU - Chalmers,JD
AU - Chotirmall,SH
DO - 10.1016/j.chom.2022.08.005
EP - 1327
PY - 2022///
SP - 1311
TI - Neisseria species as pathobionts in bronchiectasis.
T2 - Cell Host Microbe
UR - http://dx.doi.org/10.1016/j.chom.2022.08.005
UR - https://www.ncbi.nlm.nih.gov/pubmed/36108613
VL - 30
ER -