BibTex format
@article{Shelton:2023:10.1126/sciadv.adh8839,
author = {Shelton, JMG and Rhodes, J and Uzzell, CB and Hemmings, S and Brackin, AP and Sewell, TR and Alghamdi, A and Dyer, PS and Fraser, M and Borman, AM and Johnson, EM and Piel, FB and Singer, AC and Fisher, MC},
doi = {10.1126/sciadv.adh8839},
journal = {Science Advances},
pages = {1--9},
title = {Citizen science reveals landscape-scale exposures to multiazole-resistant Aspergillus fumigatus bioaerosols.},
url = {http://dx.doi.org/10.1126/sciadv.adh8839},
volume = {9},
year = {2023}
}
RIS format (EndNote, RefMan)
TY - JOUR
AB - Using a citizen science approach, we identify a country-wide exposure to aerosolized spores of a human fungal pathogen, Aspergillus fumigatus, that has acquired resistance to the agricultural fungicide tebuconazole and first-line azole clinical antifungal drugs. Genomic analysis shows no distinction between resistant genotypes found in the environment and in patients, indicating that at least 40% of azole-resistant A. fumigatus infections are acquired from environmental exposures. Hotspots and coldspots of aerosolized azole-resistant spores were not stable between seasonal sampling periods. This suggests a high degree of atmospheric mixing resulting in an estimated per capita cumulative annual exposure of 21 days (±2.6). Because of the ubiquity of this measured exposure, it is imperative that we determine sources of azole-resistant A. fumigatus to reduce treatment failure in patients with aspergillosis.
AU - Shelton,JMG
AU - Rhodes,J
AU - Uzzell,CB
AU - Hemmings,S
AU - Brackin,AP
AU - Sewell,TR
AU - Alghamdi,A
AU - Dyer,PS
AU - Fraser,M
AU - Borman,AM
AU - Johnson,EM
AU - Piel,FB
AU - Singer,AC
AU - Fisher,MC
DO - 10.1126/sciadv.adh8839
EP - 9
PY - 2023///
SN - 2375-2548
SP - 1
TI - Citizen science reveals landscape-scale exposures to multiazole-resistant Aspergillus fumigatus bioaerosols.
T2 - Science Advances
UR - http://dx.doi.org/10.1126/sciadv.adh8839
UR - https://www.ncbi.nlm.nih.gov/pubmed/37478175
UR - https://www.science.org/doi/10.1126/sciadv.adh8839
VL - 9
ER -