In this section
@article{Rafieenia:2025:10.1016/j.tibtech.2024.10.015,
author = {Rafieenia, R and Klemm, C and Hapeta, P and Fu, J and García, MG and Ledesma-Amaro, R},
doi = {10.1016/j.tibtech.2024.10.015},
journal = {Trends in Biotechnology},
pages = {601--619},
title = {Designing synthetic microbial communities with the capacity to upcycle fermentation byproducts to increase production yields},
url = {http://dx.doi.org/10.1016/j.tibtech.2024.10.015},
volume = {43},
year = {2025}
}
TY - JOUR
AB - Microbial cell factories, which convert feedstocks into a product of value, have the potential to help transition toward a bio-based economy with more sustainable ways to produce food, fuels, chemicals, and materials. One common challenge found in most bioconversions is the co-production, together with the product of interest, of undesirable byproducts or overflow metabolites. Here, we designed a strategy based on synthetic microbial communities to address this issue and increase overall production yields. To achieve our goal, we created a Yarrowia lipolytica co-culture comprising a wild-type (WT) strain that consumes glucose to make biomass and citric acid (CA), and an ‘upcycler’ strain, which consumes the CA produced by the WT strain. The co-culture produced up to two times more β-carotene compared with the WT monoculture using either minimal medium or hydrolysate. The proposed strategy has the potential to be applied to other bioprocesses and organisms.
AU - Rafieenia,R
AU - Klemm,C
AU - Hapeta,P
AU - Fu,J
AU - García,MG
AU - Ledesma-Amaro,R
DO - 10.1016/j.tibtech.2024.10.015
EP - 619
PY - 2025///
SN - 0167-7799
SP - 601
TI - Designing synthetic microbial communities with the capacity to upcycle fermentation byproducts to increase production yields
T2 - Trends in Biotechnology
UR - http://dx.doi.org/10.1016/j.tibtech.2024.10.015
UR - https://doi.org/10.1016/j.tibtech.2024.10.015
VL - 43
ER -
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