In this section
@article{Nevot:2025:10.1016/j.cels.2025.101169,
author = {Nevot, G and Santos-Moreno, J and Campamà-Sanz, N and Toloza, L and Parra-Cid, C and Jansen, PAM and Barbier, I and Ledesma-Amaro, R and van, den Bogaard EH and Güell, M},
doi = {10.1016/j.cels.2025.101169},
journal = {Cell Systems},
title = {Synthetically programmed antioxidant delivery by a domesticated skin commensal},
url = {http://dx.doi.org/10.1016/j.cels.2025.101169},
volume = {16},
year = {2025}
}
TY - JOUR
AB - Bacteria represent a promising dynamic delivery system for the treatment of disease. In the skin, the relevant location of Cutibacterium acnes within the hair follicle makes this bacterium an attractive chassis for dermal biotechnological applications. Here, we provide a genetic toolbox for the engineering of this traditionally intractable bacterium, including basic gene expression tools, biocontainment strategies, markerless genetic engineering, and dynamic transcriptional regulation. As a proof of concept, we develop an antioxidant-secreting strain capable of reducing oxidative stress in a UV stress model.
AU - Nevot,G
AU - Santos-Moreno,J
AU - Campamà-Sanz,N
AU - Toloza,L
AU - Parra-Cid,C
AU - Jansen,PAM
AU - Barbier,I
AU - Ledesma-Amaro,R
AU - van,den Bogaard EH
AU - Güell,M
DO - 10.1016/j.cels.2025.101169
PY - 2025///
SN - 2405-4720
TI - Synthetically programmed antioxidant delivery by a domesticated skin commensal
T2 - Cell Systems
UR - http://dx.doi.org/10.1016/j.cels.2025.101169
UR - https://doi.org/10.1016/j.cels.2025.101169
VL - 16
ER -
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