In this section
@article{Antunes:2025:10.1007/978-1-0716-4410-2_13,
author = {Antunes, KH and Jackson, MM and Mincham, KT and Snelgrove, RJ and Singanayagam, A},
doi = {10.1007/978-1-0716-4410-2_13},
journal = {Methods Mol Biol},
pages = {165--171},
title = {Assessment of Rhinovirus Infection in a Mouse Model of COPD.},
url = {http://dx.doi.org/10.1007/978-1-0716-4410-2_13},
volume = {2903},
year = {2025}
}
TY - JOUR
AB - A better understanding of the mechanisms governing virus-induced exacerbations of chronic obstructive pulmonary disease (COPD) is urgently needed to develop more effective therapeutic approaches. Animal models are invaluable tools for gaining mechanistic insight into innate immunity. Here, we describe the methods required to establish a short-term mouse model comprising elastase administration to induce features of COPD, combined with infection using the minor group rhinovirus serotype A1 (RV-A1). This model recapitulates the hallmark features of human virus-induced COPD exacerbation and facilitates the study of mechanisms that drive these episodes.
AU - Antunes,KH
AU - Jackson,MM
AU - Mincham,KT
AU - Snelgrove,RJ
AU - Singanayagam,A
DO - 10.1007/978-1-0716-4410-2_13
EP - 171
PY - 2025///
SP - 165
TI - Assessment of Rhinovirus Infection in a Mouse Model of COPD.
T2 - Methods Mol Biol
UR - http://dx.doi.org/10.1007/978-1-0716-4410-2_13
UR - https://www.ncbi.nlm.nih.gov/pubmed/40016465
VL - 2903
ER -
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