In this section
@article{Morris:2025:10.1111/myc.70104,
author = {Morris, AJ and McKinney, WP and Roberts, SA and Sithamparanathan, S and Chaudhry, Z and Fisher, MC},
doi = {10.1111/myc.70104},
journal = {Mycoses},
title = {Appearance of environmentlinked azole resistance in the Aspergillus fumigatus complex in New Zealand},
url = {http://dx.doi.org/10.1111/myc.70104},
volume = {68},
year = {2025}
}
TY - JOUR
AB - BackgroundUntil 2020, azole resistance in Aspergillus fumigatus complex isolates in New Zealand was due to cyp51A hot spot mutations. This report details the appearance of environment-linked tandem repeat (TR)-related azole resistance genotypes since 2021.MethodsIsolates were tested by broth micro-dilution. Clinical Laboratory Standards Institute criteria were used to define wild type (WT) and non-wild type (non-WT) isolates, which were identified by ß-tubulin gene sequencing and had their cyp51A genotype for azole resistance determined. Whole genome sequencing (WGS) was applied to two patient pairs of sequential WT and non-WT isolates.ResultsFrom January 2021 to June 2024, 15 of 147 (10.2%) A. fumigatus complex isolates were resistant or non-WT for one or more azole agents. Genotyping detected hot spot mutations in four and TR-associated resistance in nine. No mutations were detected in two isolates. Four of the five TR46 mutations were TR46/Y121F/T289A. Three of the four TR34 mutations were different. WGS of the paired isolates showed that the non-WT isolates were distinct. Azole-containing fungicides are available for home use from garden centres. Patients with TR-associated resistance did not have any obvious exposure to azole-containing fungicides. There was no evidence for healthcare-acquired transmission.ConclusionsA. fumigatus sensu stricto isolates with TR-mutations linked to environmental resistance are now present in New Zealand. Those at risk of invasive A. fumigatus infection should receive advice to avoid high-risk exposures. Reintroducing monitoring of azole-containing fungicides is recommended.
AU - Morris,AJ
AU - McKinney,WP
AU - Roberts,SA
AU - Sithamparanathan,S
AU - Chaudhry,Z
AU - Fisher,MC
DO - 10.1111/myc.70104
PY - 2025///
SN - 0933-7407
TI - Appearance of environmentlinked azole resistance in the Aspergillus fumigatus complex in New Zealand
T2 - Mycoses
UR - http://dx.doi.org/10.1111/myc.70104
UR - https://doi.org/10.1111/myc.70104
VL - 68
ER -
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