BibTex format
@article{Bouzigon:2010:10.1038/ejhg.2009.224,
author = {Bouzigon, E and Forabosco, P and Koppelman, GH and Cookson, WOCM and Dizier, M-H and Duffy, DL and Evans, DM and Ferreira, MAR and Kere, J and Laitinen, T and Malerba, G and Meyers, DA and Moffatt, M and Martin, NG and Ng, MY and Pignatti, PF and Wjst, M and Kauffmann, F and Demenais, F and Lewis, CM},
doi = {10.1038/ejhg.2009.224},
journal = {Eur J Hum Genet},
pages = {700--706},
title = {Meta-analysis of 20 genome-wide linkage studies evidenced new regions linked to asthma and atopy.},
url = {http://dx.doi.org/10.1038/ejhg.2009.224},
volume = {18},
year = {2010}
}
RIS format (EndNote, RefMan)
TY - JOUR
AB - Asthma is caused by a heterogeneous combination of environmental and genetic factors. In the context of GA2LEN (Global Allergy and Asthma European Network), we carried out meta-analyses of almost all genome-wide linkage screens conducted to date in 20 independent populations from different ethnic origins (>or=3024 families with >or=10 027 subjects) for asthma, atopic asthma, bronchial hyper-responsiveness and five atopy-related traits (total immunoglobulin E level, positive skin test response (SPT) to at least one allergen or to House Dust Mite, quantitative score of SPT (SPTQ) and eosinophils (EOS)). We used the genome scan meta-analysis method to assess evidence for linkage within bins of traditionally 30-cM width, and explored the manner in which these results were affected by bin definition. Meta-analyses were conducted in all studies and repeated in families of European ancestry. Genome-wide evidence for linkage was detected for asthma in two regions (2p21-p14 and 6p21) in European families ascertained through two asthmatic sibs. With regard to atopy phenotypes, four regions reached genome-wide significance: 3p25.3-q24 in all families for SPT and three other regions in European families (2q32-q34 for EOS, 5q23-q33 for SPTQ and 17q12-q24 for SPT). Tests of heterogeneity showed consistent evidence of linkage of SPTQ to 3p11-3q21, whereas between-study heterogeneity was detected for asthma in 2p22-p13 and 6p21, and for atopic asthma in 1q23-q25. This large-scale meta-analysis provides an important resource of information that can be used to prioritize further fine-mapping studies and also be integrated with genome-wide association studies to increase power and better interpret the outcomes of these studies.
AU - Bouzigon,E
AU - Forabosco,P
AU - Koppelman,GH
AU - Cookson,WOCM
AU - Dizier,M-H
AU - Duffy,DL
AU - Evans,DM
AU - Ferreira,MAR
AU - Kere,J
AU - Laitinen,T
AU - Malerba,G
AU - Meyers,DA
AU - Moffatt,M
AU - Martin,NG
AU - Ng,MY
AU - Pignatti,PF
AU - Wjst,M
AU - Kauffmann,F
AU - Demenais,F
AU - Lewis,CM
DO - 10.1038/ejhg.2009.224
EP - 706
PY - 2010///
SP - 700
TI - Meta-analysis of 20 genome-wide linkage studies evidenced new regions linked to asthma and atopy.
T2 - Eur J Hum Genet
UR - http://dx.doi.org/10.1038/ejhg.2009.224
UR - https://www.ncbi.nlm.nih.gov/pubmed/20068594
VL - 18
ER -