BibTex format
@article{Speliotes:2010:10.1038/ng.686,
author = {Speliotes, EK and Willer, CJ and Berndt, SI and Monda, KL and Thorleifsson, G and Jackson, AU and Lango, Allen H and Lindgren, CM and Luan, J and Magi, R and Randall, JC and Vedantam, S and Winkler, TW and Qi, L and Workalemahu, T and Heid, IM and Steinthorsdottir, V and Stringham, HM and Weedon, MN and Wheeler, E and Wood, AR and Ferreira, T and Weyant, RJ and Segre, AV and Estrada, K and Liang, L and Nemesh, J and Park, JH and Gustafsson, S and Kilpelainen, TO and Yang, J and Bouatia-Naji, N and Esko, T and Feitosa, MF and Kutalik, Z and Mangino, M and Raychaudhuri, S and Scherag, A and Smith, AV and Welch, R and Zhao, JH and Aben, KK and Absher, DM and Amin, N and Dixon, AL and Fisher, E and Glazer, NL and Goddard, ME and Heard-Costa, NL and Hoesel, V and Hottenga, JJ and Johansson, A and Johnson, T and Ketkar, S and Lamina, C and Li, S and Moffatt, MF and Myers, RH and Narisu, N and Perry, JR and Peters, MJ and Preuss, M and Ripatti, S and Rivadeneira, F and Sandholt, C and Scott, },
doi = {10.1038/ng.686},
journal = {Nature Genetics},
pages = {937--948},
title = {Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index},
url = {http://dx.doi.org/10.1038/ng.686},
volume = {42},
year = {2010}
}
RIS format (EndNote, RefMan)
TY - JOUR
AB - Obesity is globally prevalent and highly heritable, but its underlying genetic factors remain largely elusive. To identify genetic loci for obesity susceptibility, we examined associations between body mass index and approximately 2.8 million SNPs in up to 123,865 individuals with targeted follow up of 42 SNPs in up to 125,931 additional individuals. We confirmed 14 known obesity susceptibility loci and identified 18 new loci associated with body mass index (P < 5 x 10(-)(8)), one of which includes a copy number variant near GPRC5B. Some loci (at MC4R, POMC, SH2B1 and BDNF) map near key hypothalamic regulators of energy balance, and one of these loci is near GIPR, an incretin receptor. Furthermore, genes in other newly associated loci may provide new insights into human body weight regulation.
AU - Speliotes,EK
AU - Willer,CJ
AU - Berndt,SI
AU - Monda,KL
AU - Thorleifsson,G
AU - Jackson,AU
AU - Lango,Allen H
AU - Lindgren,CM
AU - Luan,J
AU - Magi,R
AU - Randall,JC
AU - Vedantam,S
AU - Winkler,TW
AU - Qi,L
AU - Workalemahu,T
AU - Heid,IM
AU - Steinthorsdottir,V
AU - Stringham,HM
AU - Weedon,MN
AU - Wheeler,E
AU - Wood,AR
AU - Ferreira,T
AU - Weyant,RJ
AU - Segre,AV
AU - Estrada,K
AU - Liang,L
AU - Nemesh,J
AU - Park,JH
AU - Gustafsson,S
AU - Kilpelainen,TO
AU - Yang,J
AU - Bouatia-Naji,N
AU - Esko,T
AU - Feitosa,MF
AU - Kutalik,Z
AU - Mangino,M
AU - Raychaudhuri,S
AU - Scherag,A
AU - Smith,AV
AU - Welch,R
AU - Zhao,JH
AU - Aben,KK
AU - Absher,DM
AU - Amin,N
AU - Dixon,AL
AU - Fisher,E
AU - Glazer,NL
AU - Goddard,ME
AU - Heard-Costa,NL
AU - Hoesel,V
AU - Hottenga,JJ
AU - Johansson,A
AU - Johnson,T
AU - Ketkar,S
AU - Lamina,C
AU - Li,S
AU - Moffatt,MF
AU - Myers,RH
AU - Narisu,N
AU - Perry,JR
AU - Peters,MJ
AU - Preuss,M
AU - Ripatti,S
AU - Rivadeneira,F
AU - Sandholt,C
AU - Scott,LJ
AU - Timpson,NJ
AU - Tyrer,JP
AU - van,Wingerden S
AU - Watanabe,RM
AU - White,CC
AU - Wiklund,F
AU - Barlassina,C
AU - Chasman,DI
AU - Cooper,MN
AU - Jansson,JO
AU - Lawrence,RW
AU - Pellikka,N
AU - Prokopenko,I
AU - Shi,J
AU - Thiering,E
AU - Alavere,H
AU - Alibrandi,MT
AU - Almgren,P
AU - Arnold,AM
AU - Aspelund,T
AU - Atwood,LD
AU - Balkau,B
AU - Balmforth,AJ
AU - Bennett,AJ
AU - Ben-Shlomo,Y
AU - Bergman,RN
AU - Bergmann,S
AU - Biebermann,H
AU - Blakemore,AI
AU - Boes,T
AU - Bonnycastle,LL
AU - Bornstein,SR
AU - Brown,MJ
AU - Buchanan,TA
DO - 10.1038/ng.686
EP - 948
PY - 2010///
SN - 1546-1718
SP - 937
TI - Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
T2 - Nature Genetics
UR - http://dx.doi.org/10.1038/ng.686
VL - 42
ER -