BibTex format
@article{Hysi:2005:hmg/ddi087,
author = {Hysi, P and Kabesch, M and Moffatt, MF and Schedel, M and Carr, D and Zhang, YM and Boardman, B and von, Mutius E and Weiland, SK and Leupold, W and Fritzsch, C and Klopp, N and Musk, AW and James, A and Nunez, G and Inohara, N and Cookson, WOC},
doi = {hmg/ddi087},
journal = {Human Molecular Genetics},
pages = {935--941},
title = {NOD1 variation, immunoglobulin E and asthma},
url = {http://dx.doi.org/10.1093/hmg/ddi087},
volume = {14},
year = {2005}
}
RIS format (EndNote, RefMan)
TY - JOUR
AB - Asthma is a familial inflammatory disease of the airways of the lung. Microbial exposures in childhood protectagainst asthma through unknown mechanisms. The innate immune system is able to identify microbial componentsthrough a variety of pattern-recognition receptors (PRRs). NOD1 is an intracellular PRR that initiatesinflammation in response to bacterial diaminopimelic acid (iE-DAP). The NOD1 gene is on chromosome 7p14, ina region that has been genetically linked to asthma. We carried out a systematic search for polymorphism in thegene. We found an insertion–deletion polymorphism (ND1 1 32656) near the beginning of intron IX thataccounted for 7% of the variation in IgE in two panels of families (P < 0.0005 in each). Allele2 (the insertion)was associated with high IgE levels. The same allele was strongly associated with asthma in an independentstudy of 600 asthmatic children and 1194 super-normal controls [odds ratio (OR) 6.3; 95% confidence interval(CI) 1.4–28.3, dominant model]. Differential binding of the two ND1 1 32656 alleles was observed to a proteinfrom nuclei of the Calu 3 epithelial cell line. In an accompanying study, the deletion allele (ND1 1 326561)was found to be associated with inflammatory bowel disease. The results indicate that intracellular recognitionof specific bacterial products affects the presence of childhood asthma.
AU - Hysi,P
AU - Kabesch,M
AU - Moffatt,MF
AU - Schedel,M
AU - Carr,D
AU - Zhang,YM
AU - Boardman,B
AU - von,Mutius E
AU - Weiland,SK
AU - Leupold,W
AU - Fritzsch,C
AU - Klopp,N
AU - Musk,AW
AU - James,A
AU - Nunez,G
AU - Inohara,N
AU - Cookson,WOC
DO - hmg/ddi087
EP - 941
PY - 2005///
SN - 1460-2083
SP - 935
TI - NOD1 variation, immunoglobulin E and asthma
T2 - Human Molecular Genetics
UR - http://dx.doi.org/10.1093/hmg/ddi087
VL - 14
ER -