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• Journal article
  Gnaim R, Ledesma-Amaro R, 2025,

  Synthetic biology of Fusarium for the sustainable production of valuable bioproducts

  , Biotechnology Advances, Vol: 81, ISSN: 0734-9750

  Synthetic biology offers transformative opportunities to optimise Fusarium species as efficient platforms for the sustainable production of diverse bioproducts. Advanced engineering techniques, including CRISPR/Cas9, RNA interference and synthetic promoters, have enhanced the manipulation of metabolic pathways, enabling higher yields of industrially relevant compounds. Recent insights from next-generation sequencing and omics technologies have significantly expanded our understanding of Fusarium's metabolic networks, leading to more precise strain engineering. Despite these advances, challenges such as metabolic bottlenecks, regulatory complexities and strain stability remain significant barriers to industrial-scale applications. The development of efficient genetic tools, together with the expansion of our knowledge of Fusarium physiology and genetics thanks to systems biology approaches, holds promise to unlock Fusarium's full potential as a sustainable cell factory. This review focuses on the genetic and metabolic tools available to enhance Fusarium's capacity to produce biofuels, pharmaceuticals, enzymes and other valuable compounds. It also highlights key innovations and discusses future directions for leveraging Fusarium as an environmentally friendly bioproduction system.

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• Journal article
  Waring BG, Lancastle L, Bell T, Bidartondo MI, García-Díaz P, Lambin X, Vanguelova E, Windram FAet al., 2025,

  Windthrow disturbance impacts soil biogeochemistry and bacterial communities in a temperate forest

  , Plant and Soil: international journal on plant-soil relationships, Vol: 512, Pages: 395-408, ISSN: 0032-079X

  AimsForests across the world are subject to disturbance via wind, wildfire, and pest and disease outbreaks. Yet we still have an incomplete understanding of how these stressors impact forest biota—particularly the soil microbes, which govern forest carbon and nutrient cycling.MethodsHere, we investigated the impact of a severe windstorm on soil bacterial communities in Kielder Forest, a temperate coniferous forest in the north of England. Within ten individual sites, defined by common stand composition and topography, we established 50 m2 plots in undisturbed stands, and in nearby stands that were moderately and/or severely disturbed by windthrow. Soils were sampled within each of the 22 study plots, and analysed for changes in carbon and nitrogen content, pH, root biomass, and bacterial community structure. We separately sequenced bacteria from bulk soils, rhizosphere soils, and root tissues to assess whether disturbance impacts varied based on the proximity of microbiota to tree roots.ResultsLess than a year after the storm, we found that the most severely disturbed stands had lower canopy cover, lower soil carbon content, higher soil pH, and a smaller fine root biomass than the undisturbed stands. Disturbance also impacted bacterial community beta-diversity, but the effects were subtle and did not vary among assemblages in bulk vs. rhizosphere soils.ConclusionsImpacts of aboveground disturbance on soil biogeochemistry can be significant, but soil bacterial communities are relatively well-buffered against these changes. However, altered patterns of root growth and carbon cycling may have longer-term implications for forest recovery after windthrow disturbances.

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• Journal article
  Kandeloos A, Eder T, Hetey D, Bismarck A, Reithofer MR, Cordill MJ, Chin JMet al., 2025,

  Expanding Transparent Covalently Attached Liquid-Like Surfaces for Icephobic Coatings with Broad Substrate Compatibility

  , ADVANCED MATERIALS INTERFACES, Vol: 12, ISSN: 2196-7350
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  • Citations: 4
• Journal article
  Ivan FX, Mac Aogáin M, Ali NABM, Tiew PY, Poh TY, Setyawati MI, Bello D, Demokritou P, Ng KW, Chotirmall SHet al., 2025,

  Occupational exposure to printer toner-emitted nanoparticles at printing facilities influences air and airway microbiomes.

  , NanoImpact, Vol: 39

  Workplace exposure to printer toner-emitted nanoparticles at commercial printing facilities poses respiratory health risks to workers on the printing floor, however, its impact on environmental and airway microbiomes and how this relates to worker health remains unknown. To investigate this, we prospectively evaluated five printing centres in Singapore, collecting air samples from office areas and printing floors and airway specimens from workers stationed in office or printing floor areas. All specimens were subjected to targeted amplicon sequencing to determine bacteriome and mycobiome profiles. Relationships between nanoparticle exposure levels, air and airway microbiomes were assessed. We reveal that nanoparticle exposure at printing facilities was significantly associated with shifts in air microbiome profiles in high-exposure printing areas relative to low-exposure office areas. Microbiome correlates of indoor air chemical exposures, mainly polycyclic aromatic hydrocarbons (PAHs) and trace elements, were identified. Lung function and airway microbiomes were influenced by nanoparticle exposure where printing floor workers demonstrate reduced lung function, independent of exposure level, with airway microbiomes characterized by enrichment of Chryseobacterium, Porphyromonas and Candida. Assessment of potential air-airway microbial crossover at each site, accounting for nanoparticle exposure levels, reveals significant increases in bacterial but not fungal crossover in printing floor workers. Taken together, this study demonstrates altered environmental and airway microbiomes at commercial printing facilities and in printing floor workers. Further research is needed to assess the long-term health impacts of such exposure including the potential for microbial profiling in printing facility design and operation.

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• Journal article
  Mall MA, Wainwright CE, Legg J, Chilvers M, Gartner S, Dittrich A-M, Stehling F, Conner S, Grant S, Suresh N, Weinstock TG, Davies JCet al., 2025,

  Elexacaftor/tezacaftor/ivacaftor in children aged ≥6 years with cystic fibrosis heterozygous for<i> F508del</i> and a minimal function mutation: results from a 96-week open-label extension study

  , EUROPEAN RESPIRATORY JOURNAL, Vol: 66, ISSN: 0903-1936
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  • Citations: 1
• Journal article
  Xue Y, Verdross P, Liang W, Woodward RT, Bismarck Aet al., 2025,

  Breaking the ice: Applications of photothermal superhydrophobic materials for efficient deicing strategies

  , ADVANCES IN COLLOID AND INTERFACE SCIENCE, Vol: 341, ISSN: 0001-8686
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  • Citations: 14
• Journal article
  Fisher MC, 2025,

  Origins of the 'vampire fungus' that causes white-nose syndrome in bats

  , NATURE, Vol: 642, Pages: 869-870, ISSN: 0028-0836
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• Journal article
  Plackett ARG, Bowman JL, Raissig MT, Borrill P, Merchant SS, Qin F, Yuen ELH, Bozkurt T, Xie Fet al., 2025,

  Exploring the diversity of plant model organisms

  , Developmental Cell, Vol: 60, Pages: 1665-1668, ISSN: 1534-5807

  Increasing plant genome research, together with advanced transformation technology, enables researchers to address their research questions more effectively in various models beyond Arabidopsis. In this collection of Voices, we asked researchers from different fields to discuss what model organisms they are using and why this helps answer their research questions.

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• Journal article
  Sand JMB, Frederiksen P, John AE, Simoes FB, Hoyer N, Prior TS, Avdic-Belltheus A, Molyneaux PL, Stewart ID, Fainberg HP, Johnson SR, Karsdal MA, Leeming DJ, Bendstrup E, Shaker SB, Maher TM, Jenkins Get al., 2025,

  Basement membrane repair response biomarker PRO-C4 predicts progression in idiopathic pulmonary fibrosis: analysis of the PFBIO and PROFILE cohorts

  , THORAX, ISSN: 0040-6376
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• Journal article
  Mehta H, Jimenez J, Ledesma-Amaro R, Stan G-Bet al., 2025,

  Investigating the potential of division of labor in synthetic bacterial communities for the production of violacein

  , ACS Synthetic Biology, ISSN: 2161-5063

  With advancements in synthetic biology and metabolic engineering, microorganisms can now be engineered to perform increasingly complex functions, which may be limited by the resources available in individual cells. Introducing heterologous metabolic pathways introduces both genetic burden due to the competition for cellular transcription and translational machinery, as well as metabolic burden due to the redirection of metabolic flux from the native metabolic pathways. Division of labor in synthetic microbial communities offers a promising approach to enhance metabolic efficiency and resilience in bioproduction. By distributing complex metabolic pathways across multiple subpopulations, the resource competition and metabolic burden imposed on an individual cell are reduced, potentially enabling more efficient production of target compounds. Violacein is a high-value pigment with antitumor properties that exemplifies such a challenge due to its complex bioproduction pathway, imposing a significant metabolic burden on host cells. In this study, we investigated the benefits of division of labor for violacein production by splitting the violacein bioproduction pathway between two subpopulations of Escherichia coli-based synthetic communities. We tested several pathway splitting strategies and reported that splitting the pathway into two subpopulations expressing VioABE and VioDC at a final composition of 60:40 yields a 2.5-fold increase in violacein production as compared to a monoculture. We demonstrated that the coculture outperforms the monoculture when both subpopulations exhibit similar metabolic burden levels, resulting in comparable growth rates, and when both subpopulations are present in sufficiently high proportions.

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