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• Journal article
  Moratto E, Tang Z, Bozkurt T, Sena Get al., 2024,

  Reduction of Phytophthora palmivora plant root infection in weak electric fields

  , Scientific Reports, Vol: 14, ISSN: 2045-2322

  The global food security crisis is partly caused by significant crop losses due to pests and pathogens, leading to economic burdens. Phytophthora palmivora, an oomycete pathogen, affects many plantation crops and costs over USD 1 billion each year. Unfortunately, there is currently no prevention plan in place, highlighting the urgent need for an effective solution. P. palmivora produces motile zoospores that respond to weak electric fields. Here, we show that external electric fields can be used to reduce root infection in two plant species. We developed two original essays to study the effects of weak electric fields on the interaction between P. palmivora’s zoospores and roots of Arabidopsis thaliana and Medicago truncatula. In the first configuration, a global artificial electric field is set up to induce ionic currents engulfing the plant roots while, in the second configuration, ionic currents are induced only locally and at a distance from the roots. In both cases, we found that weak ionic currents (250–550 μA) are sufficient to reduce zoospore attachment to Arabidopsis and Medicago roots, without affecting plant health. Moreover, we show that the same configurations decrease P. palmivora mycelial growth in Medicago roots after 24 h. We conclude that ionic currents can reduce more than one stage of P. palmivora root infection in hydroponics. Overall, our findings suggest that weak external electric fields can be used as a sustainable strategy for preventing P. palmivora infection, providing innovative prospects for agricultural crop protection.

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• Journal article
  sun M, Xiong Gao A, Liu X, Ledesma Amaro R, Bai Zet al., 2024,

  Microbial conversion of ethanol to high-value products: progress and challenges

  , Biotechnology for Biofuels and Bioproducts, Vol: 17, ISSN: 2731-3654

  Industrial biotechnology heavily relies on the microbial conversion of carbohydrate substrates derived from sugar- or starch-rich crops. This dependency poses significant challenges in the face of a rising population and food scarcity. Consequently, exploring renewable, non-competing carbon sources for sustainable bioprocessing becomes increasingly important. Ethanol, a key C2 feedstock, presents a promising alternative, especially for producing acetyl-CoA derivatives. In this review, we offer an in-depth analysis of ethanol's potential as an alternative carbon source, summarizing its distinctive characteristics when utilized by microbes, microbial ethanol metabolism pathway, and microbial responses and tolerance mechanisms to ethanol stress. We provide an update on recent progress in ethanol-based biomanufacturing and ethanol biosynthesis, discuss current challenges, and outline potential research directions to guide future advancements in this field. The insights presented here could serve as valuable theoretical support for researchers and industry professionals seeking to harness ethanol's potential for the production of high-value products.

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• Journal article
  Dobra R, Carroll S, Davies JC, Dowdall F, Duff A, Elderton A, Georgiopoulos AM, Massey-Chase R, McNally P, Puckey M, Madge Set al., 2024,

  Exploring the complexity of cystic fibrosis (CF) and psychosocial wellbeing in the 2020s: current and future challenges

  , Paediatric Respiratory Reviews, ISSN: 1526-0542

  Cystic fibrosis (CF) is traditionally associated with considerable and progressive multisystem pathology, onerous treatment burden, complex psychosocial challenges, and reduced life-expectancy [1], [2], [3], [4], [5], [6], [7], [8], [9].This decade has seen transformative change in management for many, but not all, people with CF. The most notable change comes from Cystic Fibrosis Transmembrane Receptor (CFTR) modulators, which bring significant benefits for people who are eligible for, and able to access, them [10]. However alongside, or perhaps because of, this exciting progress, the past few years have also brought important novel challenges to the psychosocial wellbeing of people with CF.This article, written as a collaboration between CF psychologists, social workers, physicians and nurses aims to provide an accessible overview of the novel psychosocial challenges now faced by children, their families, and adults with CF, and to invite consideration of their changing psychosocial requirements to inform future holistic care. Themes include geopolitical stressors such as the pandemic and its wake, a growing divide between those able or unable to access CFTR modulators, potential rapid changes in life expectancy secondary to these drugs and the inevitable associated challenges this brings; evolving body image, mental health side effects of CFTR modulators, the challenges of adherence in apparently well children and young adults, as well as the diagnostic conundrum and associated anxiety of the cystic fibrosis screen positive inconclusive diagnosis (CFSPID) label. It also highlights some unmet research and service delivery needs in the area.

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• Conference paper
  Huang Y, Ma S-F, Oldham JM, Adegunsoye A, Zhu D, Murray S, Kim JS, Bonham C, Strickland E, Linderholm AL, Lee CT, Paul T, Mannem H, Maher TM, Molyneaux PL, Strek ME, Martinez FJ, Noth Iet al., 2024,

  Machine Learning of Plasma Proteomics Classifies Diagnosis of Interstitial Lung Disease

  , International Conference of the American-Thoracic-Society (ATS), Publisher: AMER THORACIC SOC, Pages: 444-454, ISSN: 1073-449X
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• Journal article
  Calamita E, Liu WH, Ogger PP, Griffin L, Michalaki C, Murphy F, Worrell J, McCarthy C, Agro A, Hertz M, Maher TM, Lloyd CM, Molyneaux P, Kumar V, Byrne AJet al., 2024,

  Type 1 Invariant Natural Killer T Cells Drive Lung Fibrosis

  , AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 210, Pages: 521-523, ISSN: 1073-449X
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• Journal article
  Thillai M, Oldham JM, Ruggiero A, Kanavati F, McLellan T, Saini G, Johnson SR, Ble F-X, Azim A, Ostridge K, Platt A, Belvisi M, Maher TM, Molyneaux PLet al., 2024,

  Deep Learning-based Segmentation of Computed Tomography Scans Predicts Disease Progression and Mortality in Idiopathic Pulmonary Fibrosis

  , AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 210, Pages: 465-472, ISSN: 1073-449X
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• Journal article
  Mall MA, Burgel P-R, Castellani C, Davies JC, Salathe M, Taylor-Cousar JLet al., 2024,

  Cystic fibrosis.

  , Nat Rev Dis Primers, Vol: 10

  Cystic fibrosis is a rare genetic disease caused by mutations in CFTR, the gene encoding cystic fibrosis transmembrane conductance regulator (CFTR). The discovery of CFTR in 1989 has enabled the unravelling of disease mechanisms and, more recently, the development of CFTR-directed therapeutics that target the underlying molecular defect. The CFTR protein functions as an ion channel that is crucial for correct ion and fluid transport across epithelial cells lining the airways and other organs. Consequently, CFTR dysfunction causes a complex multi-organ disease but, to date, most of the morbidity and mortality in people with cystic fibrosis is due to muco-obstructive lung disease. Cystic fibrosis care has long been limited to treating symptoms using nutritional support, airway clearance techniques and antibiotics to suppress airway infection. The widespread implementation of newborn screening for cystic fibrosis and the introduction of a highly effective triple combination CFTR modulator therapy that has unprecedented clinical benefits in up to 90% of genetically eligible people with cystic fibrosis has fundamentally changed the therapeutic landscape and improved prognosis. However, people with cystic fibrosis who are not eligible based on their CFTR genotype or who live in countries where they do not have access to this breakthrough therapy remain with a high unmet medical need.

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• Journal article
  Howlett P, Gan J, Lesosky M, Feary Jet al., 2024,

  Relationship between cumulative silica exposure and silicosis: a systematic review and dose-response meta-analysis

  , THORAX, ISSN: 0040-6376
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• Journal article
  Feary J, Devaraj A, Burton M, Chua F, Coker RK, Datta A, Hewitt R, Kokosi M, Kouranos V, Reynolds CJ, Ross CL, Smith V, Ward K, Wickremasinghe M, Szram Jet al., 2024,

  Artificial stone silicosis: a UK case series

  , THORAX, ISSN: 0040-6376
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• Journal article
  Koreshkov M, Antreich SJ, Bismarck A, Fritz I, Reimhult E, Takatsuna Y, Zirbs Ret al., 2024,

  Sustainable food packaging using modified SiO₂ nanofillers in biodegradable polymers

  , MATERIALS CHEMISTRY FRONTIERS, Vol: 8, Pages: 2754-2763
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