Results
- Showing results for:
- Reset all filters
Search results
-
Journal articlesun M, Xiong Gao A, Liu X, et al., 2024,
Microbial conversion of ethanol to high-value products: progress and challenges
, Biotechnology for Biofuels and Bioproducts, Vol: 17, ISSN: 2731-3654Industrial biotechnology heavily relies on the microbial conversion of carbohydrate substrates derived from sugar- or starch-rich crops. This dependency poses significant challenges in the face of a rising population and food scarcity. Consequently, exploring renewable, non-competing carbon sources for sustainable bioprocessing becomes increasingly important. Ethanol, a key C2 feedstock, presents a promising alternative, especially for producing acetyl-CoA derivatives. In this review, we offer an in-depth analysis of ethanol's potential as an alternative carbon source, summarizing its distinctive characteristics when utilized by microbes, microbial ethanol metabolism pathway, and microbial responses and tolerance mechanisms to ethanol stress. We provide an update on recent progress in ethanol-based biomanufacturing and ethanol biosynthesis, discuss current challenges, and outline potential research directions to guide future advancements in this field. The insights presented here could serve as valuable theoretical support for researchers and industry professionals seeking to harness ethanol's potential for the production of high-value products.
-
Journal articleDobra R, Carroll S, Davies JC, et al., 2024,
Exploring the complexity of cystic fibrosis (CF) and psychosocial wellbeing in the 2020s: current and future challenges
, Paediatric Respiratory Reviews, ISSN: 1526-0542Cystic fibrosis (CF) is traditionally associated with considerable and progressive multisystem pathology, onerous treatment burden, complex psychosocial challenges, and reduced life-expectancy [1], [2], [3], [4], [5], [6], [7], [8], [9].This decade has seen transformative change in management for many, but not all, people with CF. The most notable change comes from Cystic Fibrosis Transmembrane Receptor (CFTR) modulators, which bring significant benefits for people who are eligible for, and able to access, them [10]. However alongside, or perhaps because of, this exciting progress, the past few years have also brought important novel challenges to the psychosocial wellbeing of people with CF.This article, written as a collaboration between CF psychologists, social workers, physicians and nurses aims to provide an accessible overview of the novel psychosocial challenges now faced by children, their families, and adults with CF, and to invite consideration of their changing psychosocial requirements to inform future holistic care. Themes include geopolitical stressors such as the pandemic and its wake, a growing divide between those able or unable to access CFTR modulators, potential rapid changes in life expectancy secondary to these drugs and the inevitable associated challenges this brings; evolving body image, mental health side effects of CFTR modulators, the challenges of adherence in apparently well children and young adults, as well as the diagnostic conundrum and associated anxiety of the cystic fibrosis screen positive inconclusive diagnosis (CFSPID) label. It also highlights some unmet research and service delivery needs in the area.
-
Conference paperHuang Y, Ma S-F, Oldham JM, et al., 2024,
Machine Learning of Plasma Proteomics Classifies Diagnosis of Interstitial Lung Disease
, International Conference of the American-Thoracic-Society (ATS), Publisher: AMER THORACIC SOC, Pages: 444-454, ISSN: 1073-449X -
Journal articleCalamita E, Liu WH, Ogger PP, et al., 2024,
Type 1 Invariant Natural Killer T Cells Drive Lung Fibrosis
, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 210, Pages: 521-523, ISSN: 1073-449X -
Journal articleThillai M, Oldham JM, Ruggiero A, et al., 2024,
Deep Learning-based Segmentation of Computed Tomography Scans Predicts Disease Progression and Mortality in Idiopathic Pulmonary Fibrosis
, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 210, Pages: 465-472, ISSN: 1073-449X -
Journal articleMall MA, Burgel P-R, Castellani C, et al., 2024,
Cystic fibrosis.
, Nat Rev Dis Primers, Vol: 10Cystic fibrosis is a rare genetic disease caused by mutations in CFTR, the gene encoding cystic fibrosis transmembrane conductance regulator (CFTR). The discovery of CFTR in 1989 has enabled the unravelling of disease mechanisms and, more recently, the development of CFTR-directed therapeutics that target the underlying molecular defect. The CFTR protein functions as an ion channel that is crucial for correct ion and fluid transport across epithelial cells lining the airways and other organs. Consequently, CFTR dysfunction causes a complex multi-organ disease but, to date, most of the morbidity and mortality in people with cystic fibrosis is due to muco-obstructive lung disease. Cystic fibrosis care has long been limited to treating symptoms using nutritional support, airway clearance techniques and antibiotics to suppress airway infection. The widespread implementation of newborn screening for cystic fibrosis and the introduction of a highly effective triple combination CFTR modulator therapy that has unprecedented clinical benefits in up to 90% of genetically eligible people with cystic fibrosis has fundamentally changed the therapeutic landscape and improved prognosis. However, people with cystic fibrosis who are not eligible based on their CFTR genotype or who live in countries where they do not have access to this breakthrough therapy remain with a high unmet medical need.
-
Journal articleHowlett P, Gan J, Lesosky M, et al., 2024,
Relationship between cumulative silica exposure and silicosis: a systematic review and dose-response meta-analysis
, THORAX, ISSN: 0040-6376 -
Journal articleFeary J, Devaraj A, Burton M, et al., 2024,
Artificial stone silicosis: a UK case series
, THORAX, ISSN: 0040-6376 -
Journal articleKoreshkov M, Antreich SJ, Bismarck A, et al., 2024,
Sustainable food packaging using modified SiO<sub>2</sub> nanofillers in biodegradable polymers
, MATERIALS CHEMISTRY FRONTIERS, Vol: 8, Pages: 2754-2763 -
Journal articleMeldrum OW, Donaldson GC, Narayana JK, et al., 2024,
Accelerated Lung Function Decline and Mucus-Microbe Evolution in Chronic Obstructive Pulmonary Disease
, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 210, Pages: 298-310, ISSN: 1073-449X
This data is extracted from the Web of Science and reproduced under a licence from Thomson Reuters. You may not copy or re-distribute this data in whole or in part without the written consent of the Science business of Thomson Reuters.
General enquiries
For any enquiries about the Fungal Science Network at Imperial, please contact: