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  • Journal article
    Ito K, Caramori G, Lim S, Oates T, Chung KF, Barnes PJ, Adcock IMet al., 2002,

    Expression and activity of histone deacetylases in human asthmatic airways

    , AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 166, Pages: 392-396, ISSN: 1073-449X
  • Journal article
    Waring MJ, Ben-Hadda T, Kotchevar AT, Ramdani A, Touzani R, Elkadiri S, Hakkou A, Bouakka M, Ellis Tet al., 2002,

    2,3-bifunctionalized quinoxalines: Synthesis, DNA interactions and evaluation of anticancer, anti-tuberculosis and antifungal activity

    , MOLECULES, Vol: 7, Pages: 641-656, ISSN: 1420-3049
  • Journal article
    Cookson WOCM, Harper JI, Moffatt MF, 2002,

    Genetics of atopic dermatitis

    , Immunology and Allergy Clinics of North America, Vol: 22, Pages: 199-209, ISSN: 0889-8561

    Even though the comprehension of the genetics of AD is at an early stage, further studies offer the promise of a greater understanding. The preliminary findings emphasize the importance of the skin as a barrier and suggest that the atopy that accompanies AD might be as much a secondary phenomenon as a primary phenomenon. The barrier function of the skin is not merely passive, and the skin maintains a specific immunologic environment, referred to as the skin immune system [76]. The skin immune system is characterized by the presence of a dense network of dendritic, antigen-presenting cells (Langerhan's cells) in the epidermis and perivascular localization of T lymphocytes that are activated even in the skin of normal individuals [76,77]. The polymorphic nature of genes and gene families expressed in the skin suggest a polyvalent response to a number of different stimuli, including infections. It is possible that some of these proteins might have unrecognized anti-infective properties. The recognition of the importance of genetic effects to AD, together with advances in the understanding and technology of complex genetics, will result in a new understanding of AD.

  • Journal article
    Ito K, Lim S, Caramori G, Cosio B, Chung KF, Adcock IM, Barnes PJet al., 2002,

    A molecular mechanism of action of theophylline: Induction of histone deacetylase activity to decrease inflammatory gene expression

    , PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 99, Pages: 8921-8926, ISSN: 0027-8424
  • Journal article
    Fisher MC, Rannala B, Chaturvedi V, Taylor JWet al., 2002,

    Disease surveillance in recombining pathogens:: Multilocus genotypes identify sources of human <i>Coccidioides</i> infections

    , PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 99, Pages: 9067-9071, ISSN: 0027-8424
  • Journal article
    van Hage-Hamsten M, Johansson E, Kronqvist M, Loughry A, Cookson WOCM, Moffatt MFet al., 2002,

    Associations of FcεR1-β polymorphisms with immunoglobin E antibody responses to common inhalant allergens in a rural population

    , CLINICAL AND EXPERIMENTAL ALLERGY, Vol: 32, Pages: 838-842, ISSN: 0954-7894
  • Journal article
    Davies JC, 2002,

    Pseudomonas aeruginosa in cystic fibrosis: pathogenesis and persistence.

    , Paediatr Respir Rev, Vol: 3, Pages: 128-134, ISSN: 1526-0542

    Pseudomonas aeruginosa is the major pathogen in the cystic fibrosis (CF) lung. Prevalence is high and, once acquired, chronic infection will almost always ensue. Several hypotheses related to the underlying molecular defects in CF have been suggested to explain this high rate of prevalence. These include abnormalities of airway surface liquid leading to impaired mucociliary clearance or malfunction of antibacterial peptides, increased availability of bacterial receptors, reduced ingestion of pathogens by CF cells and impaired defence related to low levels of molecules such as nitric oxide or glutathione. Further work is needed to identify which of these mechanisms is important in the early stages of infection. Once the organisms have gained a foothold in the CF airway they have a wide array of properties that enhance their survival and allow them to evade host defences and antibiotic agents successfully. Conversion to mucoidy and the formation of biofilms are two of the main mechanisms by which this is achieved. Understanding the steps involved in both initial infection and in establishing chronicity may help in the development of new treatment strategies.

  • Journal article
    Uehara Y, Iida T, Ito KJ, Iwami M, Ushioda Set al., 2002,

    Optical observation of single-electron charging effect in metallic particles

    , PHYSICAL REVIEW B, Vol: 65, ISSN: 2469-9950
  • Journal article
    Anderson GG, Leaves NI, Bhattacharyya S, Zhang Y, Walshe V, Broxholme J, Abecasis G, Levy E, Zimmer M, Cox R, Cookson WOCMet al., 2002,

    Positive association to IgE levels and a physical map of the 13q14 atopy locus.

    , Eur J Hum Genet, Vol: 10, Pages: 266-270, ISSN: 1018-4813

    Linkage of atopy and associated traits to a locus on chromosome 13q14 has been identified by several studies in diverse populations. We have previously shown the putative atopy gene to be contained within an interval of approximately 5 Mb flanked by D13S328 and D13S1269 and centred on D13S273. We have now extended this work using a top-down approach to physical mapping. A YAC contig was constructed covering the D13S328 and D13S1269 interval. Thirty-one ESTs were mapped to the contig. We constructed a BAC and PAC contig flanking D13S273 by approximately 750 kb in either direction. The interval contained 27 of the 31 ESTS from the YAC contig. Seven previously unknown microsatellites were recovered and then typed in two subject panels. A positive association between the total serum Immunoglobulin E concentration and the novel USAT24G1 microsatellite was discovered (P(corrected)<0.005) and replicated in a second panel of families. The discovery of a region of positive association within the BAC/PAC contig will permit identification of the atopy gene from this locus.

  • Journal article
    Anderson GG, Leaves NI, Bhattacharyya S, Zhang YM, Walshe V, Broxholme J, Abecasis G, Levy E, Zimmer M, Cox R, Cookson WOCMet al., 2002,

    Positive association to IgE levels and a physical map of the 13q14 atopy locus

    , EUROPEAN JOURNAL OF HUMAN GENETICS, Vol: 10, Pages: 266-270, ISSN: 1018-4813

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