Results
- Showing results for:
- Reset all filters
Search results
-
Journal articleEspeso EA, Roncal T, Díez E, et al., 2000,
On how a transcription factor can avoid its proteolytic activation in the absence of signal transduction
, EMBO JOURNAL, Vol: 19, Pages: 2391-2391, ISSN: 0261-4189- Author Web Link
- Cite
- Citations: 1
-
Journal articleChabat F, Hansell DM, Yang GZ, 2000,
Gradient correction and classification of CT lung images for the automated quantification of mosaic attenuation pattern?
, Journal of Computer Assisted Tomography, Vol: 24, Pages: 437-447 -
Journal articleEspeso EA, Arst HN, 2000,
On the mechanism by which alkaline pH prevents expression of an acid-expressed gene
, MOLECULAR AND CELLULAR BIOLOGY, Vol: 20, Pages: 3355-3363, ISSN: 0270-7306- Author Web Link
- Cite
- Citations: 83
-
Journal articleMoffatt MF, Traherne JA, Abecasis GR, et al., 2000,
Single nucleotide polymorphism and linkage disequilibrium within the TCR alpha/delta locus.
, Hum Mol Genet, Vol: 9, Pages: 1011-1019, ISSN: 0964-6906Much attention is being given to the identification of common disease genes through whole-genome linkage disequilibrium (LD) screens with single nucleotide polymorphisms (SNPs). Simulation studies have suggested that useful LD is unlikely to extend beyond 3 kb, and that > 500,000 SNPs may be needed for comprehensive coverage of the genome. The TCR alpha/delta locus on chromosome 14q contains many V, J and D segments that combine with constant domains to produce either an alpha or a delta chain of the T cell receptor. Multiple SNPs have been recognized within the V segments, and it has been suggested that variation within the locus may modify the course of autoimmune and allergic diseases. We have examined LD within an 850 kb section of the TCR alpha/delta locus on chromosome 14q by typing 24 V gene segment SNPs and two microsatellites. One hundred and fifty-nine nuclear and extended families were genotyped in order to derive haplotypes, and the pair-wise LD between SNPs was investigated in 600 haplotypes from unrelated individuals (the parents). The mean extent of useful LD was much greater than suggested by simulations: significant LD was relatively common at 250 kb and was detectable beyond 500 kb. The mean extent of LD was twice as far between alleles of low frequency than between common alleles. The distribution of LD was highly irregular and concentrated in three distinct islands. The results differ from those obtained by simulation, and if they are typical of other genomic regions, suggest that the minimum number of markers necessary for comprehensive LD mapping may be reduced by at least an order of magnitude.
-
Conference paperMohanty AK, Bismarck A, Aranberri I, et al., 2000,
Characterization of natural fibers using ζ-potential measurements:: Surface properties and the water uptake behavior of modified jute, sisal, and coir fibers.
, Publisher: AMER CHEMICAL SOC, Pages: U527-U527, ISSN: 0065-7727 -
Conference paperWilli O, Barringer L, Bell A, et al., 2000,
Inertial confinement fusion and fast ignitor studies
, 17th IAEA Fusion Energy Conference, Publisher: INT ATOMIC ENERGY AGENCY, Pages: 537-545, ISSN: 0029-5515- Author Web Link
- Cite
- Citations: 9
-
Journal articleEspeso EA, Roncal T, Díez E, et al., 2000,
On how a transcription factor can avoid its proteolytic activation in the absence of signal transduction
, EMBO JOURNAL, Vol: 19, Pages: 719-728, ISSN: 0261-4189- Author Web Link
- Cite
- Citations: 47
-
Journal articleArst HN, 2000,
Apathy rewards misconduct - and everybody suffers
, NATURE, Vol: 403, Pages: 478-478, ISSN: 0028-0836- Author Web Link
- Cite
- Citations: 1
-
Journal articleChaure P, Gurr SJ, Spanu P, 2000,
Stable transformation of <i>Erysiphe graminis</i>, an obligate biotrophic pathogen of barley
, NATURE BIOTECHNOLOGY, Vol: 18, Pages: 205-207, ISSN: 1087-0156- Author Web Link
- Cite
- Citations: 63
-
Journal articleFisher MC, Koenig GL, White TJ, et al., 2000,
Pathogenic clones versus environmentally driven population increase:: Analysis of an epidemic of the human fungal pathogen <i>Coccidioides immitis</i>
, JOURNAL OF CLINICAL MICROBIOLOGY, Vol: 38, Pages: 807-813, ISSN: 0095-1137- Author Web Link
- Cite
- Citations: 73
This data is extracted from the Web of Science and reproduced under a licence from Thomson Reuters. You may not copy or re-distribute this data in whole or in part without the written consent of the Science business of Thomson Reuters.
General enquiries
For any enquiries about the Fungal Science Network at Imperial, please contact: