BibTex format
@article{Zhang:2003:10.1038/ng1166,
author = {Zhang, Y and Leaves, NI and Anderson, GG and Ponting, CP and Broxholme, J and Holt, R and Edser, P and Bhattacharyya, S and Dunham, A and Adcock, IM and Pulleyn, L and Barnes, PJ and Harper, JI and Abecasis, G and Cardon, L and White, M and Burton, J and Matthews, L},
doi = {10.1038/ng1166},
journal = {Nature Genetics},
pages = {181--186},
title = {Positional cloning of a quantitative trait locus on chromosome 13q14 that influences immunoglobulin E levels and asthma},
url = {http://dx.doi.org/10.1038/ng1166},
volume = {34},
year = {2003}
}
RIS format (EndNote, RefMan)
TY - JOUR
AB - Atopic or immunoglobulin E (IgE)-mediated diseases include the common disorders of asthma, atopic dermatitis and allergic rhinitis1. Chromosome 13q14 shows consistent linkage to atopy and the total serum IgE concentration2,3,4,5,6. We previously identified association between total serum IgE levels and a novel 13q14 microsatellite (USAT24G1; ref. 7) and have now localized the underlying quantitative-trait locus (QTL) in a comprehensive single-nucleotide polymorphism (SNP) map. We found replicated association to IgE levels that was attributed to several alleles in a single gene, PHF11. We also found association with these variants to severe clinical asthma. The gene product (PHF11) contains two PHD zinc fingers and probably regulates transcription. Distinctive splice variants were expressed in immune tissues and cells.
AU - Zhang,Y
AU - Leaves,NI
AU - Anderson,GG
AU - Ponting,CP
AU - Broxholme,J
AU - Holt,R
AU - Edser,P
AU - Bhattacharyya,S
AU - Dunham,A
AU - Adcock,IM
AU - Pulleyn,L
AU - Barnes,PJ
AU - Harper,JI
AU - Abecasis,G
AU - Cardon,L
AU - White,M
AU - Burton,J
AU - Matthews,L
DO - 10.1038/ng1166
EP - 186
PY - 2003///
SN - 1061-4036
SP - 181
TI - Positional cloning of a quantitative trait locus on chromosome 13q14 that influences immunoglobulin E levels and asthma
T2 - Nature Genetics
UR - http://dx.doi.org/10.1038/ng1166
UR - http://hdl.handle.net/10044/1/57392
VL - 34
ER -