BibTex format
@article{Fulgenzi:2026:10.1038/s41416-026-03536-5,
author = {Fulgenzi, CAM and Dalla, Pria A and Zhao, Y and Leone, AG and Weir, J and Puccio, I and Tuohinto, KS and Ojala, PM and Bower, M and Pinato, DJ},
doi = {10.1038/s41416-026-03536-5},
journal = {Br J Cancer},
pages = {1544--1553},
title = {In-depth characterisation of the tumour microenvironment reveals HHV-8-dependent immune regulation in HIV-associated and classic Kaposi sarcoma.},
url = {http://dx.doi.org/10.1038/s41416-026-03536-5},
volume = {135},
year = {2026}
}
RIS format (EndNote, RefMan)
TY - JOUR
AB - BACKGROUND: Kaposi's sarcoma (KS) is the most common malignancy occurring in people living with HIV (PLWH). The clinical course of KS in PLWH established on combined anti-retroviral therapy (cART) resembles that of classic KS. OBJECTIVES: To compare the clinical and biological characteristics of HIV-associated KS in patients with well-controlled viral infection (N = 21) and non-HIV-associated KS (N = 19). METHODS: Clinical data were prospectively collected from patients treated at the National Centre for HIV malignancies at Chelsea & Westminster Hospital. Targeted transcriptomic analysis and multiplex immune-fluorescence were performed on archival tumour samples. RESULTS: Clinical outcomes were comparable between groups. The tumour microenvironment (TME) of non-HIV-associated KS was characterised by transcriptional upregulation of pathways associated with adaptive and innate immunity and angiogenesis. The TME of HIV-associated cases was associated with lower infiltration of activated CD4 cells. In both cohorts, we found the expression of HHV-8 genes to positively correlate with activated CD4, CD8, NK and immune checkpoint gene expression. CONCLUSIONS: The KS TME in the presence of well-controlled HIV infection is characterised by a lower degree of inflammation and more pronounced epithelial to mesenchymal transition. We also identified intra-tumoral HHV-8 gene expression as a driver of TME composition.
AU - Fulgenzi,CAM
AU - Dalla,Pria A
AU - Zhao,Y
AU - Leone,AG
AU - Weir,J
AU - Puccio,I
AU - Tuohinto,KS
AU - Ojala,PM
AU - Bower,M
AU - Pinato,DJ
DO - 10.1038/s41416-026-03536-5
EP - 1553
PY - 2026///
SP - 1544
TI - In-depth characterisation of the tumour microenvironment reveals HHV-8-dependent immune regulation in HIV-associated and classic Kaposi sarcoma.
T2 - Br J Cancer
UR - http://dx.doi.org/10.1038/s41416-026-03536-5
UR - https://www.ncbi.nlm.nih.gov/pubmed/42552365
VL - 135
ER -