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  • Journal article
    Grossman N, 2018,

    Modulation without surgical intervention Noninvasive deep brain stimulation can be achieved via temporally interfering electric fields

    , SCIENCE, Vol: 361, Pages: 461-462, ISSN: 0036-8075
  • Journal article
    Grossman N, Bono D, Dedic N, Kodandaramaiah SB, Rudenko A, Suk H-J, Cassara AM, Neufeld E, Kuster N, Tsai L-H, Pascual-Leone A, Boyden ESet al., 2017,

    Noninvasive Deep Brain Stimulation via Temporally Interfering Electric Fields

    , CELL, Vol: 169, Pages: 1029-1041.e16, ISSN: 0092-8674

    We report a noninvasive strategy for electrically stimulating neurons at depth. By delivering to the brain multiple electric fields at frequencies too high to recruit neural firing, but which differ by a frequency within the dynamic range of neural firing, we can electrically stimulate neurons throughout a region where interference between the multiple fields results in a prominent electric field envelope modulated at the difference frequency. We validated this temporal interference (TI) concept via modeling and physics experiments, and verified that neurons in the living mouse brain could follow the electric field envelope. We demonstrate the utility of TI stimulation by stimulating neurons in the hippocampus of living mice without recruiting neurons of the overlying cortex. Finally, we show that by altering the currents delivered to a set of immobile electrodes, we can steerably evoke different motor patterns in living mice.

  • Journal article
    Grossman N, Simiaki V, Martinet C, Toumazou C, Schultz SR, Nikolic Ket al., 2013,

    The spatial pattern of light determines the kinetics and modulates backpropagation of optogenetic action potentials

    , JOURNAL OF COMPUTATIONAL NEUROSCIENCE, Vol: 34, Pages: 477-488, ISSN: 0929-5313
  • Conference paper
    Nikolic K, Jarvis S, Grossman N, Schultz Set al., 2013,

    Computational Models of Optogenetic Tools for Controlling Neural Circuits with Light

    , 35th Annual International Conference of the IEEE-Engineering-in-Medicine-and-Biology-Society (EMBC), Publisher: IEEE, Pages: 5934-5937, ISSN: 1557-170X
  • Conference paper
    Manoli Z, Grossman N, Samaras T, 2012,

    Theoretical Investigation of Transcranial Alternating Current Stimulation using Realistic Head Model

    , 34th Annual International Conference of the IEEE Engineering-in-Medicine-and-Biology-Society (EMBS), Publisher: IEEE, Pages: 4156-4159, ISSN: 1557-170X

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