Noninvasive deep brain stimulation
N. Grossman, D. Bono, S. Kodandaramaiah, A. Rudenko, A. Cassara, E. Neufeld, S. A. Anteraper, A. Takahashi, N. Kuster, L. Tsai, A. Pascual-Leone, E. S. Boyden “Noninvasive deep brain stimulation via delivery of temporally interfering electric fields.” Cell 169.6 (2017): 1029-1041.
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Journal articleVinao-Carl M, Gal-Shohet Y, Rhodes E, et al., 2024,
For over a decade, electrophysiological studies have reported correlations between attention / perception and the phase of spontaneous brain oscillations. To date, these findings have been interpreted as evidence that the brain uses neural oscillations to sample and predict upcoming stimuli. Yet, evidence from simulations have shown that analysis artefacts could also lead to spurious pre-stimulus oscillations that appear to predict future brain responses. To address this discrepancy, we conducted an experiment in which visual stimuli were presented in time to specific phases of spontaneous alpha and theta oscillations. This allowed us to causally probe the role of ongoing neural activity in visual processing independent of the stimulus-evoked dynamics. Our findings did not support a causal link between spontaneous alpha / theta rhythms and behaviour. However, spurious correlations between theta phase and behaviour emerged offline using gold-standard time-frequency analyses. These findings are a reminder that care should be taken when inferring causal relationships between neural activity and behaviour using acausal analysis methods.
Journal articleRintoul JL, Neufeld E, Butler C, et al., 2023,
Heterodyning of signals through physical multiplication is the building block of numerous modern technologies. Yet, it has been mostly limited to the interaction between electromagnetic fields. Here, we report that heterodyning occurs also between acoustic and electric fields in liquid electrolytes. We predict acoustoelectric heterodyning via computational field modelling, which accounts for the vector nature of the electrolytic acoustoelectric interaction. We then experimentally validate the spatiotemporal characteristics of the field emerging from the acoustoelectric heterodyning effect. The electric field distribution generated by the applied fields can be controlled by the propagating acoustic field and the orientation of the applied electric field, enabling the focusing of the resulting electric field at remote locations. Finally, we demonstrate detection of multi-frequency ionic currents at a distant focal location via signal demodulation using pressure waves in electrolytic liquids. As such, acoustoelectric heterodyning could open possibilities in non-invasive biomedical and bioelectronics applications.
Journal articleGrossman N, 2018,
Journal articleGrossman N, Bono D, Dedic N, et al., 2017,
We report a noninvasive strategy for electrically stimulating neurons at depth. By delivering to the brain multiple electric fields at frequencies too high to recruit neural firing, but which differ by a frequency within the dynamic range of neural firing, we can electrically stimulate neurons throughout a region where interference between the multiple fields results in a prominent electric field envelope modulated at the difference frequency. We validated this temporal interference (TI) concept via modeling and physics experiments, and verified that neurons in the living mouse brain could follow the electric field envelope. We demonstrate the utility of TI stimulation by stimulating neurons in the hippocampus of living mice without recruiting neurons of the overlying cortex. Finally, we show that by altering the currents delivered to a set of immobile electrodes, we can steerably evoke different motor patterns in living mice.
Journal articleGrossman N, Simiaki V, Martinet C, et al., 2013,
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