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@article{Kurtin:2026:10.1038/s41398-026-03845-6,
author = {Kurtin, DL and Herlinger, K and Hayes, A and Hand, L and Fonville, L and Hill, RG and Nutt, DJ and Lingford-Hughes, AR and Paterson, LM},
doi = {10.1038/s41398-026-03845-6},
journal = {Translational Psychiatry},
title = {Task-related differences in network connectivity and dynamics in people with severe opioid use disorder compared with healthy controls},
url = {http://dx.doi.org/10.1038/s41398-026-03845-6},
volume = {16},
year = {2026}
}

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TY  - JOUR
AB  - One approach to addressing the immense unmet need for treatments of severe opioid use disorder (sOUD) is to understand more about associated changes in the brain’s reward circuitry. It has been shown that during reward anticipation in the Monetary Incentive Delay (MID) task, people with severe substance use disorder (SUD) show blunted responses in reward neural circuitry compared with healthy controls (HC). Conversely, drug-related cues result in heightened responses in the same neural reward circuitry in those with SUD compared with HC. However, it is unclear how such dysfunctional reward processing is related to neural correlates of other processes commonly dysregulated in addiction, such as attention and cognition. The aim of this work was to evaluate whether people with sOUD show different relationships between reward networks to networks that regulate cognition, attention, sensory processes, and more. Then, we evaluated whether there is a spatial relationship between differences in brain function and atlases of μ-opioid receptor (MOR) and dopamine D2 receptor (DRD2) availability. We collected fMRI data while people with sOUD receiving methadone (MD; n = 25) and HC (n = 22) completed the MID and cue reactivity tasks. We evaluated differences in functional connectivity (FC) and measures of brain state dynamics. Partial least squared (PLS) analysis computed the spatial relationship between FC metrics to MOR and D2DR availability. We found that MD participants generally exhibited weaker miFC compared to HC in both tasks except when comparing the difference in miFC during anticipation of monetary reward or drug related stimuli vs neutral stimuli. Contrasts between rewarding or drug-related to neutral stimuli showed MD participants had stronger miFC between reward/anti-reward networks to regions in the control network and default mode Network (DMN) in both tasks. Analysis of brain state dynamics showed the DMN was more prevalent i
AU  - Kurtin,DL
AU  - Herlinger,K
AU  - Hayes,A
AU  - Hand,L
AU  - Fonville,L
AU  - Hill,RG
AU  - Nutt,DJ
AU  - Lingford-Hughes,AR
AU  - Paterson,LM
DO  - 10.1038/s41398-026-03845-6
PY  - 2026///
SN  - 2158-3188
TI  - Task-related differences in network connectivity and dynamics in people with severe opioid use disorder compared with healthy controls
T2  - Translational Psychiatry
UR  - http://dx.doi.org/10.1038/s41398-026-03845-6
UR  - https://doi.org/10.1038/s41398-026-03845-6
VL  - 16
ER  -

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Citation

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Publications

Key publications

Modulation without surgical intervention

Noninvasive deep brain stimulation

Key publications

Neuron Cell with Channelrhodopsin-2 Mutants light study

Multi-site optical excitation using ChR2 and micro-LED array

Citation

BibTex format

RIS format (EndNote, RefMan)

General enquiries