In this section

Publications

Modulation without surgical intervention

N. Grossman "Modulation without surgical intervention." Science 361.6401 (2018): 461-462.

Noninvasive deep brain stimulation

N. Grossman, D. Bono, S. Kodandaramaiah, A. Rudenko, A. Cassara, E. Neufeld, S. A. Anteraper, A. Takahashi, N. Kuster, L. Tsai, A. Pascual-Leone, E. S. Boyden “Noninvasive deep brain stimulation via delivery of temporally interfering electric fields.” Cell 169.6 (2017): 1029-1041.

Neuron Cell with Channelrhodopsin-2 Mutants light study

N. Grossman, K. Nikolic, C. Toumazou, P. Degenaar “Modeling Study of the Light Stimulation of a Neuron Cell with Channelrhodopsin-2 Mutants.” IEEE Trans Biomed

Multi-site optical excitation using ChR2 and micro-LED array

N. Grossman, V. Pohrer, M. Grubb, G. T. Kennedy, K. Nikolic, M. A. A. Neil, M. D. Dawson, J. Burrone, P. Degenaar “Multi-site optical excitation using ChR2 and micro-LED array.” J. Neural Eng. 7 (2010): 16004.

Citation

BibTex format

@article{Carhart-Harris:2026:10.1038/s41467-026-71962-3,
author = {Carhart-Harris, R},
doi = {10.1038/s41467-026-71962-3},
journal = {Nature Communications},
title = {Human brain changes after first psilocybin use},
url = {http://dx.doi.org/10.1038/s41467-026-71962-3},
volume = {17},
year = {2026}
}

Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Psychedelics have robust effects on acute brain function and long-term behavior but whether they also cause enduring functional and anatomical brain changes is largely unknown. In an exploratory, placebo-controlled, within-subjects, electroencephalography (EEG), and magnetic resonance imaging (MRI) study in 28 healthy, entirely psychedelic-naive participants, anatomical and functional brain changes are detected from one-hour to one-month after a single high-dose (25 mg) of psilocybin. Increases in cognitive flexibility, psychological insight, and well-being are seen at one-month. Diffusion tensor imaging (DTI) done before and one-month after 25mg psilocybin reveals decreased axial diffusivity bilaterally in prefrontal-subcortical tracts that correlate with decreases in brain network modularity (fMRI) over the same month. Enduring functional brain changes are largely absent, but network modularity change (numerical decrease) negatively correlates with well-being change (significant increase), in line with previous findings in depression. Increased cortical signal entropy (EEG) at 1- and 2-hours post-dosing predicts improved psychological well-being at one-month. Next-day psychological insight mediates the entropy to well-being relationship. All effects are exclusive to 25mg psilocybin; no effects occur with a 1mg psilocybin placebo.
AU  - Carhart-Harris,R
DO  - 10.1038/s41467-026-71962-3
PY  - 2026///
SN  - 2041-1723
TI  - Human brain changes after first psilocybin use
T2  - Nature Communications
UR  - http://dx.doi.org/10.1038/s41467-026-71962-3
UR  - https://www.nature.com/articles/s41467-026-71962-3
VL  - 17
ER  -