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Publications

Modulation without surgical intervention

N. Grossman "Modulation without surgical intervention." Science 361.6401 (2018): 461-462.

Noninvasive deep brain stimulation

N. Grossman, D. Bono, S. Kodandaramaiah, A. Rudenko, A. Cassara, E. Neufeld, S. A. Anteraper, A. Takahashi, N. Kuster, L. Tsai, A. Pascual-Leone, E. S. Boyden “Noninvasive deep brain stimulation via delivery of temporally interfering electric fields.” Cell 169.6 (2017): 1029-1041.

Neuron Cell with Channelrhodopsin-2 Mutants light study

N. Grossman, K. Nikolic, C. Toumazou, P. Degenaar “Modeling Study of the Light Stimulation of a Neuron Cell with Channelrhodopsin-2 Mutants.” IEEE Trans Biomed

Multi-site optical excitation using ChR2 and micro-LED array

N. Grossman, V. Pohrer, M. Grubb, G. T. Kennedy, K. Nikolic, M. A. A. Neil, M. D. Dawson, J. Burrone, P. Degenaar “Multi-site optical excitation using ChR2 and micro-LED array.” J. Neural Eng. 7 (2010): 16004.

Citation

BibTex format

@article{David:2026:10.1002/alz.71547,
author = {David, MCB and Mallas, E-J and Kolanko, MA and Del, Giovane M and Kurtin, DL and Nilforooshan, R and Zimmerman, KA and Bonet, Olivares C and Lally, PJ and CR&T, Group of UKDRI and Sharp, DJ and Malhotra, PA and Scott, G},
doi = {10.1002/alz.71547},
journal = {Alzheimers Dement},
title = {Cortical synchrony is reduced in Alzheimer's disease and relates to arousal state.},
url = {http://dx.doi.org/10.1002/alz.71547},
volume = {22},
year = {2026}
}

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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - INTRODUCTION: The brain is a complex dynamical system, influenced by arousal state. Cortical synchrony supports information processing and is disrupted in Alzheimer's disease (AD). Locus coeruleus (LC) integrity and pupillometry index arousal system structure and function. METHODS: Sixty-four AD and 26 controls underwent resting-state pupillometry-fMRI. Neuromelanin MRI and Addenbrooke's Cognitive Examination were conducted. Mean and standard deviation of blood oxygen level dependent (BOLD) phase coherence yielded synchrony and metastability, respectively. Leading Eigenvector Dynamics Analysis (LEiDA) produced coherence-based states. RESULTS: AD had reduced global synchrony [b = -0.90, p < 0.001], metastability [b = -0.61, p < 0.01], LEiDA "global coherence state" occupancy [b = -0.06, p < 0.01], and LC integrity [b = -0.37, p = 0.01]. Synchrony [b = 0.19, p = 0.01] and LC integrity [b = 0.17, p < 0.01] related to cognition and one another [b = 0.27, p = 0.01]. Pupil-linked arousal correlated with synchrony and global coherence state maintenance. DISCUSSION: In health, cortical activity shows widespread but dynamic synchrony across regions to meet changing demands. In AD, arousal dysfunction appears to disrupt these dynamics, impacting cognition.
AU  - David,MCB
AU  - Mallas,E-J
AU  - Kolanko,MA
AU  - Del,Giovane M
AU  - Kurtin,DL
AU  - Nilforooshan,R
AU  - Zimmerman,KA
AU  - Bonet,Olivares C
AU  - Lally,PJ
AU  - CR&T,Group of UKDRI
AU  - Sharp,DJ
AU  - Malhotra,PA
AU  - Scott,G
DO  - 10.1002/alz.71547
PY  - 2026///
TI  - Cortical synchrony is reduced in Alzheimer's disease and relates to arousal state.
T2  - Alzheimers Dement
UR  - http://dx.doi.org/10.1002/alz.71547
UR  - https://www.ncbi.nlm.nih.gov/pubmed/42273876
VL  - 22
ER  -