BibTex format

author = {Dong, R and Liu, R and Gaffney, P and Schaepertoens, M and Marchetti, P and Williams, C and Chen, R and Livingston, A},
doi = {10.1038/s41557-018-0169-6},
journal = {Nature Chemistry},
pages = {136--145},
title = {Sequence-defined multifunctional polyethers via liquid-phase synthesis with molecular sieving},
url = {},
volume = {11},
year = {2019}

RIS format (EndNote, RefMan)

AB - Synthetic chemists have devoted tremendous effort towards the production of precision synthetic polymers with defined sequences and specific functions. However, the creation of a general technology that enables precise control over monomer sequence, with efficient isolation of the target polymers, is highly challenging. Here, we report a robust strategy for the production of sequence-defined synthetic polymers through a combination of liquid-phase synthesis and selective molecular sieving. The polymer is assembled in solution with real-time monitoring to ensure couplings proceed to completion, on a three-armed star-shaped macromolecule to maximize efficiency during the molecular sieving process. This approach is applied to the construction of sequence-defined polyethers, with side-arms at precisely defined locations that can undergo site-selective modification after polymerization. Using this versatile strategy, we have introduced structural and functional diversity into sequence-defined polyethers, unlocking their potential for real-life applications in nanotechnology, healthcare and information storage.
AU - Dong,R
AU - Liu,R
AU - Gaffney,P
AU - Schaepertoens,M
AU - Marchetti,P
AU - Williams,C
AU - Chen,R
AU - Livingston,A
DO - 10.1038/s41557-018-0169-6
EP - 145
PY - 2019///
SN - 1755-4330
SP - 136
TI - Sequence-defined multifunctional polyethers via liquid-phase synthesis with molecular sieving
T2 - Nature Chemistry
UR -
UR -
VL - 11
ER -